Evidence map›Paper›PMID 30639168›Full record

ArticleParkinsonism & related disorders2019

Multimodal dopaminergic and free-water imaging in Parkinson's disease.

Jing Yang, Derek B Archer, Roxana G Burciu, Martijn L T M Müller, Arnab Roy, Edward Ofori, Nicolaas I Bohnen, Roger L Albin, David E Vaillancourt

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinsonism & related disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 54 citations in OpenAlex.

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  20. Thalamic Dorsomedial Nucleus Free Water Correlates with Cognitive Decline in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Jing YangDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL,USA; Department of Neurology, West China Hospital of Sichuan University, Chengdu, China. Electronic address: jingyang_cc@163.com.
Derek B ArcherDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL,USA. Electronic address: archerdb@ad.ufl.edu.
Roxana G BurciuDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, DE, USA. Electronic address: roxana.g.burciu@ufl.edu.
Martijn L T M MüllerDepartment of Radiology, University of Michigan, Ann Arbor, MI, USA; University of Michigan, Morris K Udall Center of Excellence for Parkinson's Disease Research, Ann Arbor, MI, USA. Electronic address: mtmuller@umich.edu.
Arnab RoyDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL,USA. Electronic address: aroy1@ufl.edu.
Edward OforiCollege of Health Solutions, Arizona State University, Phoenix, AZ, USA. Electronic address: eofori@hhp.ufl.edu.
Nicolaas I BohnenDepartment of Radiology, University of Michigan, Ann Arbor, MI, USA; University of Michigan, Morris K Udall Center of Excellence for Parkinson's Disease Research, Ann Arbor, MI, USA; Department of Neurology, University of Michigan, Ann Arbor, MI, USA; Neurology Service and GRECC, VAAAHS, Ann Arbor, MI, USA. Electronic address: nbohnen@umich.edu.
Roger L AlbinUniversity of Michigan, Morris K Udall Center of Excellence for Parkinson's Disease Research, Ann Arbor, MI, USA; Department of Neurology, University of Michigan, Ann Arbor, MI, USA; Neurology Service and GRECC, VAAAHS, Ann Arbor, MI, USA. Electronic address: ralbin@med.umich.edu.
David E VaillancourtDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL,USA; Department of Neurology, University of Florida, Gainesville, FL,USA; Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA. Electronic address: vcourt@ufl.edu.
University of Florida · USUniversity of Michigan · USArizona State University · USSichuan University · CNUniversity of Delaware · US

Funding

Public Outreach and Education CoreP50NS091856 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALBIN, ROGER L · 2014 to 2019
$10.1M
Scaling and Sequencing Motor Output in Humans: fMRI StudyR01NS052318 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI VAILLANCOURT, DAVID E · 2005 to 2020
$6.0M
Neuroimaging Biomarkers in Parkinsonism: Differentiating Subtypes and Tracking Disease ProgressionU01NS102038 · NINDS · UNIVERSITY OF FLORIDA · PI CORCOS, DANIEL M., VAILLANCOURT, DAVID E · 2017 to 2019
$2.3M
NINDS NIH HHS P50 NS091856NINDS NIH HHS R01 NS052318NINDS NIH HHS U01 NS102038
6 · The paper itself

Abstract

introductionWhen using free-water diffusion imaging or positron emission tomography (PET), it is established that substania nigra microstructure and presynaptic dopamine activity are impaired in early PD. It is not well understood if these two forms of degeneration are redundant, or if they each provide a unique contribution to the clinical motor and cognitive symptoms.

methodsA total of 129 PD and 75 control individuals underwent motor and cognitive evaluations, and in vivo [11C]dihydrotetrabenazine (DTBZ) monoaminergic brain PET imaging and diffusion imaging. Correlations between free-water in the substantia nigra and striatal PET measures were analyzed. Unbiased multiple regression using a backward elimination method was performed between clinical severity and all imaging measures.

resultsInverse correlations were found between free-water in posterior substantia nigra and DTBZ binding in putamen and caudate. Multiple regression revealed that increased free-water in the posterior substantia nigra, decreased DTBZ binding in putamen, and age were predictors of higher Hoehn and Yahr stage, MDS-UPDRS III scores, and posture and gait sub-scores. Increased posterior substantia nigra free-water alone was associated tremor scores. Free-water in caudate and putamen did not predict measures of motor performance. Decreased DTBZ binding in caudate, increased free-water in caudate and posterior substantia nigra were associated with higher dementia ratings.

conclusionsThese findings suggest that free-water in the posterior substantia nigra and presynaptic dopamine imaging in striatum are uniquely associated with the clinical symptoms of PD, indicating that each imaging modality may be measuring a unique mechanism relevant to nigrostriatal degeneration.

Indexed as

AdultAgedAged, 80 and overBrainDopamineFemaleHumansMaleMiddle AgedParkinson DiseasePositron-Emission TomographyTetrabenazineTremorWaterdihydrotetrabenazineDopamineTetrabenazineWaterBasal gangliaDiffusion magnetic resonance imagingMultimodal imagingParkinson's diseasePETSubstantia nigra

Identifiers

PMID30639168
PMCPMC6589363
OpenAlexW2907317448

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.