ArticleAdvances in biological regulation2019
Crosstalk between Ras and inositol phosphate signaling revealed by lithium action on inositol monophosphatase in Schizophyllum commune.
Article in Advances in biological regulation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Seasonal Shifts in Metal-Associated Fungal Community Dynamics and Functional Potentials in Chinese Coastal Sediments.Environmental microbiology · 2026Article
- Improving the Proteome-Mining ofJournal of fungi (Basel, Switzerland) · 2025Article
- Transcriptome Analysis Reveals Mycelial and Fruiting Responses to Lithium Chloride inJournal of fungi (Basel, Switzerland) · 2024Article
- Inositol Signaling in the Basidiomycete FungusJournal of fungi (Basel, Switzerland) · 2021Article
- Balancing Positive and Negative Selection:mBio · 2021Article
- Response of the wood-decay fungus Schizophyllum commune to co-occurring microorganisms.PloS one · 2020Article
- Fungal Kinases With a Sweet Tooth: Pleiotropic Roles of Their Phosphorylated Inositol Sugar Products in the Pathogenicity ofFrontiers in cellular and infection microbiology · 2019Review
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Mushroom forming basidiomycete Schizophyllum commune has been used as a tractable model organism to study fungal sexual development. Ras signaling activation via G-protein-coupled receptors (GPCRs) has been postulated to play a significant role in the mating and development of S. commune. In this study, a crosstalk between Ras signaling and inositol phosphate signaling by inositol monophosphatase (IMPase) is revealed. Constitutively active Ras1 leads to the repression of IMPase transcription and lithium action on IMPase activity is compensated by the induction of IMPase at transcriptome level. Astonishingly, in S. commune lithium induces a considerable shift to inositol phosphate metabolism leading to a massive increase in the level of higher phosphorylated inositol species up to the inositol pyrophosphates. The lithium induced metabolic changes are not observable in a constitutively active Ras1 mutant. In addition to that, proteome profile helps us to elucidate an overview of lithium action to the broad aspect of fungal metabolism and cellular signaling. Taken together, these findings imply a crosstalk between Ras and inositol phosphate signaling.
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