ArticleEBioMedicine2019
The blood transcriptome of childhood malaria.
Article in EBioMedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Host Transcriptional Meta-signatures Reveal Diagnostic Biomarkers for Plasmodium falciparum Malaria.The Journal of infectious diseases · 2024Pooled it
- Multicohort transcriptome analysis of whole blood identifies robust human response signatures in Plasmodium falciparum infections.Malaria journal · 2022Pooled it
- Reviewing and assessing existing meta-analysis models and tools.Briefings in bioinformatics · 2021Pooled it
- Transcriptome profiling of peripheral blood mononuclear cells from highly susceptible adult cattle infected with a virulent strain of Babesia bovis.Parasites & vectors · 2025Article
- Comparative Analysis of Immune Response Genes Induced by a Virulent or Attenuated Strain ofInternational journal of molecular sciences · 2025Article
- Transcriptomic and Proteomic Insights into Host Immune Responses in Pediatric Severe Malarial Anemia: Dysregulation in HSP60-70-TLR2/4 Signaling and Altered Glutamine Metabolism.Pathogens (Basel, Switzerland) · 2024Article
- The impact of Plasmodium-driven immunoregulatory networks on immunity to malaria.Nature reviews. Immunology · 2024Review
- Clinical immunity to malaria involves epigenetic reprogramming of innate immune cells.PNAS nexus · 2024Article
- Entire expressed peripheral blood transcriptome in pediatric severe malarial anemia.Nature communications · 2024Article
- The malarial blood transcriptome: translational applications.Biochemical Society transactions · 2024Review
- scRNA-seq reveals elevated interferon responses and TNF-α signaling via NFkB in monocytes in children with uncomplicated malaria.Experimental biology and medicine (Maywood, N.J.) · 2024Article
- Identifying effective diagnostic biomarkers for childhood cerebral malaria in Africa integrating coexpression analysis with machine learning algorithm.European journal of medical research · 2023Article
- Genome-wide liver transcriptomic profiling of a malaria mouse model reveals disturbed immune and metabolic responses.Parasites & vectors · 2023Article
- Diagnosis of cerebral malaria: Tools to reduceFrontiers in cellular and infection microbiology · 2023Review
- Malian children infected with Plasmodium ovale and Plasmodium falciparum display very similar gene expression profiles.PLoS neglected tropical diseases · 2023Article
- Endothelial type I interferon response and brain diseases: identifying STING as a therapeutic target.Frontiers in cell and developmental biology · 2023Review
- Transcriptional Profiles Analysis of COVID-19 and Malaria Patients Reveals Potential Biomarkers in Children.bioRxiv : the preprint server for biology · 2022Article
- An update on cerebral malaria for therapeutic intervention.Molecular biology reports · 2022Review
- Analysis of gene expression profiles to study malaria vaccine dose efficacy and immune response modulation.Genomics & informatics · 2022Article
- Molecular profiling reveals features of clinical immunity and immunosuppression in asymptomatic P. falciparum malaria.Molecular systems biology · 2022Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTranscriptomic research of blood cell lineages supports the understanding of distinct features of the immunopathology in human malaria.
methodsWe used microarray hybridization, validated by real-time RT-PCR to analyze whole blood gene expression in healthy Gabonese children and children with various conditions of Plasmodium falciparum infection, including i) asymptomatic infection, ii) uncomplicated malaria, iii) malaria associated with severe anemia and iv) cerebral malaria.
findingsOur data indicate that the expression profile of 22 genes significantly differed among the investigated groups. Immunoglobulin production, complement regulation and IFN beta signaling, in particular IRF7 and ISRE binding signatures in the corresponding genes, were most conspicuous. Down-regulation in cerebral malaria seems to rely on AhRF, GABP and HIF1 hypoxia transcription factors. ARG1, BPI, CD163, IFI27, HP and TNFAIP6 transcript levels correlated positively with lactatemia, and negatively with hemoglobin concentrations.
interpretationDifferences in gene expression profile reflect distinct immunopathological mechanisms of P. falciparum infection. They emerge as potential prognostic markers for early therapeutic measures and need to be validated further. FUND: This work was supported by a grant of the NGFN (Nationales Genomforschungsnetz 01GS0114) and by a CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil) PhD scholarship for A. B. W. Boldt. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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