Evidence map›Paper›PMID 30638601›Full record

ArticleThe American journal of the medical sciences2019

Transmission Electron Microscopy Improves the Diagnostic Sensitivity in Nonbacterial Etiology of Severe Pneumonia: A Retrospective Study.

Juan Jiang, Chengping Hu, Yuanyuan Li, Pinhua Pan, Xiaoli Su, Pengbo Deng, Junpu Wang, Xiaoying Wu

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of the medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Aptamer Cocktail to Detect Multiple Species of Mycoplasma in Cell Culture.International journal of molecular sciences · 2020
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Juan JiangDepartment of Respiratory and Critical Care Medicine, National Key Clinical Specialty and.
Chengping HuDepartment of Respiratory and Critical Care Medicine, National Key Clinical Specialty and.
Yuanyuan LiDepartment of Respiratory and Critical Care Medicine, National Key Clinical Specialty and. Electronic address: leeround@csu.edu.cn.
Pinhua PanDepartment of Respiratory and Critical Care Medicine, National Key Clinical Specialty and.
Xiaoli SuDepartment of Respiratory and Critical Care Medicine, National Key Clinical Specialty and.
Pengbo DengDepartment of Respiratory and Critical Care Medicine, National Key Clinical Specialty and.
Junpu WangDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Xiaoying WuDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
National Clinical Research · USCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSevere pneumonia is responsible for great mortality and morbidity worldwide, and early-applied effective anti-infective therapy can improve the prognosis of patients. However, identification of infectious agents in severe pneumonia remains a major challenge so far. In this study, the potential utility of transmission electron microscopy (TEM) in detecting nonbacterial pathogens in patients with severe pneumonia was retrospectively evaluated. MATERIALS AND

methodsA total of 106 patients diagnosed with severe pneumonia at our hospital from September 2015 to December 2017 were included, and their baseline clinical characteristics were collected. Nonbacterial infectious agents detected by TEM in bronchoalveolar lavage fluid (BALF) and serological tests were summarized. The detection rates were further compared between TEM and serological tests.

resultsBALF examination under the transmission electron microscope revealed 24 viruses, 16 mycoplasmas, 18 chlamydia, 2 fungi and 74 bacteria in 99 samples, among which 61 samples were mixed infections. The combined use of serological tests and TEM significantly improved the detection rate of nonbacterial infectious agents in patients with severe pneumonia.

conclusionsOur data support that implementation of TEM could improve the sensitivity for detecting viruses, atypical pathogens and mixed infections in BALF from patient of severe pneumonia. Therefore, TEM may be used as an auxiliary diagnostic method of other microbiological tests in severe pneumonia.

Indexed as

AdolescentAdultAgedAged, 80 and overBronchoalveolar Lavage FluidChildChild, PreschoolFemaleHumansInfantInfant, NewbornMaleMicroscopy, Electron, TransmissionMiddle AgedMycosesPneumoniaBronchoalveolar lavage fluidEtiologic diagnosisPathogensSevere pneumoniaTransmission electron microscopy

Identifiers

PMID30638601
PMCPMC7093854
OpenAlexW2903492095

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.