Evidence map›Paper›PMID 30638540›Full record

ArticleMethods in enzymology2019

Applications of Dissolution-DNP for NMR Screening.

Yaewon Kim, Christian Hilty

Abstract read
In one paragraph

Article in Methods in enzymology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Rapid Fragment Screening byAngewandte Chemie (International ed. in English) · 2026
    Article
  3. Science advances · 2025
    Article
  4. BoostingScience advances · 2024
    Article
  5. Article
  6. Article
  7. Ultrafast Fragment Screening Using Photo-Hyperpolarized (CIDNP) NMR.Journal of the American Chemical Society · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Chembiochem : a European journal of chemical biology · 2021
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yaewon KimChemistry Department, Texas A&M University, College Station, TX, United States.
Christian HiltyChemistry Department, Texas A&M University, College Station, TX, United States. Electronic address: chilty@tamu.edu.

Funding

Development of Platform for Ligand Screening using Hyperpolarized NMRR21GM107927 · NIGMS · TEXAS A&M UNIVERSITY · PI HILTY, CHRISTIAN B. · 2013 to 2015
$534k
NIGMS NIH HHS R21 GM107927
6 · The paper itself

Abstract

Experimental screening for protein-ligand interactions is a central task in drug discovery. Nuclear magnetic resonance (NMR) spectroscopy enables the determination of binding affinities, as well as the measurement of structural and dynamic parameters governing the interaction. With traditional liquid-state NMR relying on a nuclear spin polarization on the order of 10

Indexed as

LigandsCyclic AMP-Dependent Protein KinasesMagnetic Resonance SpectroscopyProtein BindingProtein ConformationProteinsSolubilityCyclic AMP-Dependent Protein KinasesLigandsProteinsDissolution dynamic nuclear polarizationDrug discoveryFlow-NMRLigand-based screeningProtein–ligand interactionsRelaxometry

Identifiers

PMID30638540
PMCPMC8179729

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.