Evidence map›Paper›PMID 30638449›Full record

ArticleeLife2019

High resolution cryo-EM structure of the helical RNA-bound Hantaan virus nucleocapsid reveals its assembly mechanisms.

Benoît Arragain, Juan Reguera, Ambroise Desfosses, Irina Gutsche, Guy Schoehn, Hélène Malet

Open access · greenAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
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  5. The Phlebovirus Ribonucleoprotein: An Overview.Methods in molecular biology (Clifton, N.J.) · 2024
    Review
  6. Article
  7. Negative and ambisense RNA virus ribonucleocapsids: more than protective armor.Microbiology and molecular biology reviews : MMBR · 2023
    Review
  8. Article
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  11. Article
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Benoît ArragainElectron Microscopy and Methods Group, Université Grenoble Alpes, CNRS, CEA, Institute for Structural Biology, Grenoble, France.ORCID 0000-0002-5593-4682
Juan RegueraComplexes Macromoléculaires Viraux, Aix-Marseille Université, CNRS, INSERM, AFMB UMR 7257, Marseille, France.ORCID 0000-0003-4977-7948
Ambroise DesfossesElectron Microscopy and Methods Group, Université Grenoble Alpes, CNRS, CEA, Institute for Structural Biology, Grenoble, France.ORCID 0000-0002-6525-5042
Irina GutscheElectron Microscopy and Methods Group, Université Grenoble Alpes, CNRS, CEA, Institute for Structural Biology, Grenoble, France.ORCID 0000-0002-1908-3921
Guy SchoehnElectron Microscopy and Methods Group, Université Grenoble Alpes, CNRS, CEA, Institute for Structural Biology, Grenoble, France.ORCID 0000-0002-1459-3201
Hélène MaletElectron Microscopy and Methods Group, Université Grenoble Alpes, CNRS, CEA, Institute for Structural Biology, Grenoble, France.ORCID 0000-0002-2834-7386
Centre National de la Recherche Scientifique · FRUniversité Grenoble Alpes · FRAix-Marseille Université · FRCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FR

Funding

IDEX IRS grant University of Grenoble G7H-IRS17H50Université Grenoble Alpes G7H-IRS17H50
6 · The paper itself

Abstract

Negative-strand RNA viruses condense their genome into helical nucleocapsids that constitute essential templates for viral replication and transcription. The intrinsic flexibility of nucleocapsids usually prevents their full-length structural characterisation at high resolution. Here, we describe purification of full-length recombinant metastable helical nucleocapsid of Hantaan virus (

Indexed as

Virus AssemblyAnimalsCryoelectron MicroscopyGenome, ViralHantaan virusHEK293 CellsHumansInsectaNucleocapsidProtein ConformationRNA, ViralRNA, ViralBunyaviralesHantaanHantavirusmolecular biophysicsNucleocapsidnucleoproteinreplicationstructural biologyvirus

Identifiers

PMID30638449
PMCPMC6365055
OpenAlexW2910508562

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.