Evidence map›Paper›PMID 30638447›Full record

ArticleeLife2019

PARIS, an optogenetic method for functionally mapping gap junctions.

Ling Wu, Ao Dong, Liting Dong, Shi-Qiang Wang, Yulong Li

Abstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

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  16. Article
  17. Approaches to Study Gap Junctional Coupling.Frontiers in cellular neuroscience · 2021
    Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Ling WuState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.ORCID 0000-0003-3921-5626
Ao DongState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.ORCID 0000-0002-2821-9528
Liting DongPeking-Tsinghua Center for Life Sciences, Beijing, China.ORCID 0000-0001-8396-374X
Shi-Qiang WangState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
Yulong LiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.ORCID 0000-0002-9166-9919

Funding

Beijing Brain Initiation Z181100001518004Beijing Brain Initiative Z181100001518004Ministry of Science and Technology of the People's Republic of China 2015CB856402Ministry of Science and Technology of the People's Republic of China 2016YFA0500401Ministry of Science and Technology of the People's Republic of China Grant 2015CB856402Ministry of Science and Technology of the People's Republic of China Grant 2016YFA0500401National Natural Science Foundation of China 31371442National Natural Science Foundation of China 31630035National Natural Science Foundation of China 31671118National Natural Science Foundation of China Projects 31371442National Natural Science Foundation of China Projects 31630035National Natural Science Foundation of China Projects 31671118
6 · The paper itself

Abstract

Cell-cell communication via gap junctions regulates a wide range of physiological processes by enabling the direct intercellular electrical and chemical coupling. However, the in vivo distribution and function of gap junctions remain poorly understood, partly due to the lack of non-invasive tools with both cell-type specificity and high spatiotemporal resolution. Here, we developed PARIS (

Indexed as

OptogeneticsAnimalsCell CommunicationCell LineDrosophilaGap JunctionsHEK293 CellsHeLa CellsHumansMyocytes, CardiacNeuronscardiomyocytesD. melanogasterelectrical synapsesgap junctionsneuroscienceolfactory systemoptogenetics

Identifiers

PMID30638447
PMCPMC6396999

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.