Evidence map›Paper›PMID 30638365›Full record

ArticleACS infectious diseases2019

Diverse Chemical Compounds Target Plasmodium falciparum Plasma Membrane Lipid Homeostasis.

Suyash Bhatnagar, Sezin Nicklas, Joanne M Morrisey, Daniel E Goldberg, Akhil B Vaidya

Abstract read
In one paragraph

Article in ACS infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Mutational analysis of an antimalarial drug target,Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. GeneTargeter: AutomatedThe CRISPR journal · 2022
    Article
  7. Frontiers in cellular and infection microbiology · 2022
    Article
  8. The role of cholesterol in invasion and growth of malaria parasites.Frontiers in cellular and infection microbiology · 2022
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Suyash BhatnagarCenter for Molecular Parasitology, Department of Microbiology and Immunology , Drexel University College of Medicine , 2900 Queen Lane , Philadelphia , Pennsylvania 19129 , United States of America.
Sezin NicklasCenter for Molecular Parasitology, Department of Microbiology and Immunology , Drexel University College of Medicine , 2900 Queen Lane , Philadelphia , Pennsylvania 19129 , United States of America.
Joanne M MorriseyCenter for Molecular Parasitology, Department of Microbiology and Immunology , Drexel University College of Medicine , 2900 Queen Lane , Philadelphia , Pennsylvania 19129 , United States of America.
Daniel E GoldbergDepartment of Medicine, Division of Infectious Diseases , Washington University School of Medicine , 4990 Children's Place , St. Louis , Missouri 63110 , United States of America.
Akhil B VaidyaCenter for Molecular Parasitology, Department of Microbiology and Immunology , Drexel University College of Medicine , 2900 Queen Lane , Philadelphia , Pennsylvania 19129 , United States of America.ORCID 0000-0003-1063-5571
Drexel University · USWashington University in St. Louis · US

Funding

ORGANELLE GENOMES OF MALARIAL PARASITESR01AI028398 · NIAID · MCP HAHNEMANN UNIVERSITY · PI AKHIL B VAIDYA · 1989 to 2026
$10.1M
Molecular Pathways Affected by Drugs that Disrupt Na+ Homeostasis in Malaria ParasitesR01AI132508 · NIAID · DREXEL UNIVERSITY · PI AKHIL B VAIDYA · 2017 to 2026
$5.7M
Molecular Pathways Targeted by Potent Antimalarial Pyrazole CompoundsR01AI098413 · NIAID · DREXEL UNIVERSITY · PI VAIDYA, AKHIL B · 2012 to 2015
$1.9M
NIAID NIH HHS R01 AI028398NIAID NIH HHS R01 AI098413NIAID NIH HHS R01 AI132508
6 · The paper itself

Abstract

Lipid homeostasis is essential to the maintenance of life. We previously reported that disruptions of the parasite Na

Indexed as

AntimalarialsCalcium-Transporting ATPasesCell MembraneErythrocytesHomeostasisHumansLipid MetabolismLipidsMalaria, FalciparumPlasmodium falciparumProtozoan ProteinsSodiumAntimalarialsCalcium-Transporting ATPasesLipidsProtozoan ProteinsSodiumlipid homeostasisNa+ independentPlasmodiumsaponin sensitivity

Identifiers

PMID30638365
PMCPMC6461493
OpenAlexW2896001644

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.