Evidence map›Paper›PMID 30638108›Full record

ArticleJournal of the American Heart Association2019

Elevated Sera sST2 Is Associated With Heart Failure in Men ≤50 Years Old With Myocarditis.

Michael J Coronado, Katelyn A Bruno, Lori A Blauwet, Carsten Tschöpe, Madeleine W Cunningham, Sabine Pankuweit, Sophie van Linthout, Eun-Seok Jeon, Dennis M McNamara, Jan Krejčí and 10 more

Abstract readComparative StudyMulticenter Study
In one paragraph

Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed.

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  13. Gender disparities in outcomes of cardiogenic shock secondary to Takotsubo cardiomyopathy.American heart journal plus : cardiology research and practice · 2024
    Article
  14. Mechanisms underlying sex differences in autoimmunity.The Journal of clinical investigation · 2024
    Review
  15. Article
  16. Review
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  20. Review

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Michael J Coronado1 Department of Environmental Health Sciences Johns Hopkins Bloomberg School of Public Health Baltimore MD.
Katelyn A Bruno1 Department of Environmental Health Sciences Johns Hopkins Bloomberg School of Public Health Baltimore MD.
Lori A Blauwet3 Department of Cardiovascular Diseases Mayo Clinic Rochester MN.
Carsten Tschöpe4 Department of Cardiology and Berlin-Brandenburg Center for Regenerative Medicine Campus Virchow Klinikum Charite- Universitaetsmedizin Berlin Berlin Germany.
Madeleine W Cunningham5 Department of Microbiology and Immunology University of Oklahoma Health Sciences Center Oklahoma City OK.
Sabine Pankuweit6 Department of Internal Medicine and Cardiology University Hospital Giessen and Marburg Marburg Germany.
Sophie van Linthout4 Department of Cardiology and Berlin-Brandenburg Center for Regenerative Medicine Campus Virchow Klinikum Charite- Universitaetsmedizin Berlin Berlin Germany.
Eun-Seok Jeon7 Medicine Samsung Medical Center Seoul Korea.
Dennis M McNamara8 Heart and Vascular Institute University of Pittsburgh PA.
Jan Krejčí9 Department of Cardiovascular Diseases St. Anne's University Hospital and Masaryk University Brno Czech Republic.
Julie Bienertová-Vašků10 Department of Pathological Physiology and the Research Center for the Toxic Compounds in the Environment Faculty of Sciences Masaryk University Brno Czech Republic.
Erika J Douglass1 Department of Environmental Health Sciences Johns Hopkins Bloomberg School of Public Health Baltimore MD.
Eric D Abston1 Department of Environmental Health Sciences Johns Hopkins Bloomberg School of Public Health Baltimore MD.
Adriana Bucek1 Department of Environmental Health Sciences Johns Hopkins Bloomberg School of Public Health Baltimore MD.
J Augusto Frisancho1 Department of Environmental Health Sciences Johns Hopkins Bloomberg School of Public Health Baltimore MD.
Merci S Greenaway1 Department of Environmental Health Sciences Johns Hopkins Bloomberg School of Public Health Baltimore MD.
Anneliese R Hill2 Department of Cardiovascular Medicine Mayo Clinic Jacksonville FL.
Heinz-Peter Schultheiss11 Institute for Cardiac Diagnostics and Therapy (IKDT) Berlin Germany.
Leslie T Cooper2 Department of Cardiovascular Medicine Mayo Clinic Jacksonville FL.
DeLisa Fairweather1 Department of Environmental Health Sciences Johns Hopkins Bloomberg School of Public Health Baltimore MD.

Funding

Traning Program in Environmental Health SciencesT32ES007141 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI Marsha Wills-Karp · 1985 to 2026
$22.2M
AUTOIMMUNE DETERMINANTS OF HUMAN CARDIAC MYOSINR01HL056267 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI COOPER, LESLIE T, CUNNINGHAM, MADELEINE W. · 1997 to 2013
$4.7M
Autoimmune Mechanisms in Human MyocarditisR01HL135165 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI COOPER, LESLIE T, CUNNINGHAM, MADELEINE W. · 2017 to 2021
$2.9M
Regulating heart disease: the adjuvant effect of viral infection.R01HL087033 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI FAIRWEATHER, DELISA · 2007 to 2011
$2.5M
Sex Differences in Complement during Myocarditis/DCMR01HL111938 · NHLBI · MAYO CLINIC JACKSONVILLE · PI FAIRWEATHER, DELISA · 2012 to 2015
$1.6M
Endocrine disruptors effect on inflammatory heart diseaseR21ES024414 · NIEHS · MAYO CLINIC JACKSONVILLE · PI FAIRWEATHER, DELISA · 2014 to 2015
$440k
NHLBI NIH HHS R01 HL056267NHLBI NIH HHS R01 HL087033NHLBI NIH HHS R01 HL111938NHLBI NIH HHS R01 HL135165NIEHS NIH HHS R21 ES024414NIEHS NIH HHS T32 ES007141
6 · The paper itself

Abstract

Background Myocarditis is an important cause of acute and chronic heart failure. Men with myocarditis have worse recovery and an increased need for transplantation compared with women, but the reason for the sex difference remains unclear. Elevated sera soluble (s) ST2 predicts mortality from acute and chronic heart failure, but has not been studied in myocarditis patients. Methods and Results Adults with a diagnosis of clinically suspected myocarditis (n=303, 78% male) were identified according to the 2013 European Society of Cardiology position statement. Sera sST2 levels were examined by ELISA in humans and mice and correlated with heart function according to sex and age. Sera sST2 levels were higher in healthy men ( P=8×10

Indexed as

AdultAge FactorsAnimalsBiomarkersBiopsyDisease Models, AnimalEnzyme-Linked Immunosorbent AssayFemaleFollow-Up StudiesHeart FailureHumansInterleukin-1 Receptor-Like 1 ProteinMaleMiceMice, Inbred BALB CMiddle AgedBiomarkersIL1RL1 protein, humanInterleukin-1 Receptor-Like 1 Proteinbiomarkersheart failuremyocarditissex differencessST2

Identifiers

PMID30638108
PMCPMC6497352

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.