Evidence map›Paper›PMID 30638074›Full record

ArticleHuman gene therapy2019

Cardiac-Directed Expression of Adenylyl Cyclase Catalytic Domain (

Zhen Tan, Dimosthenis Giamouridis, N Chin Lai, Young Chul Kim, Tracy Guo, Bing Xia, Mei Hua Gao, H Kirk Hammond

Open access · bronzeAbstract read
In one paragraph

Article in Human gene therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Human gene therapy · 2022
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Zhen Tan1 Veterans Affairs San Diego Healthcare System, San Diego, California, and University of California San Diego, San Diego, California.
Dimosthenis Giamouridis1 Veterans Affairs San Diego Healthcare System, San Diego, California, and University of California San Diego, San Diego, California.
N Chin Lai1 Veterans Affairs San Diego Healthcare System, San Diego, California, and University of California San Diego, San Diego, California.
Young Chul Kim1 Veterans Affairs San Diego Healthcare System, San Diego, California, and University of California San Diego, San Diego, California.
Tracy Guo1 Veterans Affairs San Diego Healthcare System, San Diego, California, and University of California San Diego, San Diego, California.
Bing Xia1 Veterans Affairs San Diego Healthcare System, San Diego, California, and University of California San Diego, San Diego, California.
Mei Hua Gao1 Veterans Affairs San Diego Healthcare System, San Diego, California, and University of California San Diego, San Diego, California.
H Kirk Hammond1 Veterans Affairs San Diego Healthcare System, San Diego, California, and University of California San Diego, San Diego, California.
University of California, San Diego · US

Funding

Vector Production CoreP01HL066941 · NHLBI · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI HAMMOND, H. KIRK · 2001 to 2017
$34.8M
Urocortin-2 Gene Transfer for CHF: a Paracrine Approach Using Intravenous AAV8R42HL122038 · NHLBI · RENOVA THERAPEUTICS, INC. · PI HAMMOND, H. KIRK · 2014 to 2017
$1.8M
Translational Studies of Paracrine CV Gene TransferI01BX001515 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI HAMMOND, H. KIRK · 2012 to 2015
–
Urocortin 2 Gene Transfer for Heart Failure with Preserved Ejection FractionI01BX003774 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI HAMMOND, H. KIRK · 2017 to 2025
–
BLRD VA I01 BX001515BLRD VA I01 BX003774NHLBI NIH HHS P01 HL066941NHLBI NIH HHS R42 HL122038
6 · The paper itself

Abstract

A fusion protein (C1C2) constructed by fusing the intracellular C1 and C2 segments of adenylyl cyclase type 6 (AC6) retains beneficial effects of AC6 expression, without increasing cyclic adenosine monophosphate generation. The effects of cardiac-directed

Indexed as

Gene ExpressionAdenylyl CyclasesAnimalsCalciumCatalytic DomainEchocardiographyFemaleFibrosisHeart FailureHeart Function TestsMaleMiceMice, TransgenicMyocytes, CardiacProtein Interaction Domains and MotifsSarcomeresAdenylyl CyclasesCalciumcardiomyopathygene therapyheart failureLV pressure overload

Identifiers

PMID30638074
PMCPMC6589496
OpenAlexW2909823522

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.