Evidence map›Paper›PMID 30638028›Full record

ArticleAIDS research and human retroviruses2019

The Evolving Facets of Bacterial Vaginosis: Implications for HIV Transmission.

Lyle R McKinnon, Sharon L Achilles, Catriona S Bradshaw, Adam Burgener, Tania Crucitti, David N Fredricks, Heather B Jaspan, Rupert Kaul, Charu Kaushic, Nichole Klatt and 8 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS research and human retroviruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 174 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
174citing papers in PubMed, 4 pooled it
25.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

174 citing papers in PubMed, 4 syntheses or guidelines pooled it, 277 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. The Effect of Exogenous Sex Steroids on the Vaginal Microbiota: A Systematic Review.Frontiers in cellular and infection microbiology · 2021
    Pooled it
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  7. Vaginal microbiota stability over 18 months in young student women in France.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
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114 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 17 institutions in 8 countries.

Lyle R McKinnon1 Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada.
Sharon L Achilles3 Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania.
Catriona S Bradshaw5 Central Clinical School, Monash University, Melbourne, Australia.
Adam Burgener7 National HIV and Retrovirology Labs, Public Health Agency of Canada, Winnipeg, Canada.
Tania Crucitti10 Centre Pasteur du Cameroun, Yaoundé, Cameroon.
David N Fredricks11 Vaccine and Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Heather B Jaspan13 Seattle Children's Research Institute and University of Washington, Seattle, Washington.
Rupert Kaul15 Department of Immunology, University of Toronto, Toronto, Canada.
Charu Kaushic17 McMaster Immunology Research Centre, Michael G. DeGroote Centre for Learning and Discovery, McMaster University, Hamilton, Canada.
Nichole Klatt19 Department of Pediatrics, University of Miami, Miami, Florida.
Douglas S Kwon20 Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Cambridge, Massachusetts.
Jeanne M Marrazzo22 Division of Infectious Disease, University of Alabama at Birmingham, Birmingham, Alabama.
Lindi Masson23 Division of Medical Virology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
R Scott McClelland12 Department of Medicine, University of Washington, Seattle, Washington.
Jacques Ravel27 Institute for Genome Sciences and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland.
Janneke H H M van de Wijgert28 Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
Lenka A Vodstrcil5 Central Clinical School, Monash University, Melbourne, Australia.
Gilda Tachedjian30 Disease Elimination Program, Life Sciences Discipline, Burnet Institute, Melbourne, Australia.
Monash University · AUCentre for the AIDS Programme of Research in South Africa · ZACentre Pasteur du Cameroun · CMFred Hutch Cancer Center · USMagee-Womens Research Institute · USMcMaster University Medical Centre · CAPublic Health Agency of Canada · CARagon Institute of MGH, MIT and Harvard · USRMIT University · AUUniversity of Alabama at Birmingham · USUniversity of Liverpool · GBUniversity of Manitoba · CAUniversity of Maryland, Baltimore · USUniversity of Miami · USUniversity of Toronto · CAUniversity of Washington · USWellcome Centre for Infectious Diseases Research in Africa · ZA

Funding

Serologic Biomarkers of Human Sexually Transmitted Infection and DiseaseU19AI084044 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI BAVOIL, PATRIK M, RAVEL, JACQUES · 2009 to 2018
$22.8M
Inflammation and the vaginal metagenome in HIV acquisitionR01AI111918 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI KWON, DOUGLAS, VIRGIN, HERBERT W · 2014 to 2017
$2.5M
CIHR PJT-156123CIHR TMI-138658NIAID NIH HHS R01 AI111918NIAID NIH HHS U19 AI084044
6 · The paper itself

Abstract

Bacterial vaginosis (BV) is a common yet poorly understood vaginal condition that has become a major focus of HIV transmission and immunology research. Varied terminologies are used by clinicians and researchers to describe microbial communities that reside in the female reproductive tract (FRT), which is driven, in part, by microbial genetic and metabolic complexity, evolving diagnostic and molecular techniques, and multidisciplinary perspectives of clinicians, epidemiologists, microbiologists, and immunologists who all appreciate the scientific importance of understanding mechanisms that underlie BV. This Perspectives article aims to clarify the varied terms used to describe the cervicovaginal microbiota and its "nonoptimal" state, under the overarching term of BV. The ultimate goal is to move toward language standardization in future literature that facilitates a better understanding of the impact of BV on FRT immunology and risk of sexually transmitted infections, including HIV.

Indexed as

Disease Transmission, InfectiousAdultCytokinesDisease SusceptibilityFemaleHigh-Throughput Nucleotide SequencingHIV InfectionsHumansInflammationLactobacillusMicrobiotaRiskRNA, Ribosomal, 16STerminology as TopicVaginaVaginosis, BacterialCytokinesRNA, Ribosomal, 16Sbacterial vaginosisfemale reproductive tractgenital inflammationHIVHIV transmissionvaginal microbiota

Identifiers

PMID30638028
PMCPMC6434601
OpenAlexW2909229435

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.