Trial reportAmerican journal of hematology2019
Bone marrow transplantation for adolescents and young adults with sickle cell disease: Results of a prospective multicenter pilot study.
Registry-linked trialOpen access · greenAbstract readClinical TrialMulticenter Study
In one paragraph
Trial report in American journal of hematology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04523376 (Closely Matched Unrelated Donor Peripheral Blood Stem Cell Transplantation With TCRαβ+ T Cell and B Cell Depletion For Patients With Sickle Cell Disease and Thalassemia Major), which is not on this map. Cited by 49 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 2 pooled it
6.8field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Closely Matched Unrelated Donor Peripheral Blood Stem Cell Transplantation With TCRαβ+ T Cell and B Cell Depletion For Patients With Sickle Cell Disease and Thalassemia Major
Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Frequency of red blood cell allo-immunization in transfused patients with sickle cell disease in Africa: a systematic review with meta-analysis.African health sciences · 2024Pooled it
- A systematic review of quality of life in sickle cell disease and thalassemia after stem cell transplant or gene therapy.Blood advances · 2021Pooled it
- Nonmyeloablative HLA-identical sibling transplant for sickle cell disease in children: a multicenter prospective study.Blood advances · 2026Trial
- Hematopoietic cell transplant compared with standard care in adolescents and young adults with sickle cell disease.Blood advances · 2025Trial
- Nonmyeloablative and reduced-intensity conditioning for allogeneic hematopoietic stem cell transplantation in sickle cell disease: a narrative review of safety, engraftment, and graft-versus-host-disease outcomes in adults and high-risk populations.Bone marrow transplantation · 2026Review
- Excellent clinical and patient-reported outcomes following matched sibling donor BMT for sickle cell disease.Bone marrow transplantation · 2026Article
- Article
- Hematopoietic Cell Transplantation for Sickle Cell Disease.Children (Basel, Switzerland) · 2026Review
- Exploring Affordable Curative Therapy for Sickle Cell Disease in Africa: A Comprehensive Overview.American journal of hematology · 2026Review
- Curative Approach to the Treatment of Beta-Thalassemia and Sickle Cell Disease with Hematopoietic Stem Cell Transplantation.Journal of clinical medicine · 2026Review
- Informed shared decision-making or rigid eligibility and exclusion criteria for gene therapy for sickle cell disease?Blood advances · 2026Review
- Oral Radiographic Changes in Severe Sickle Cell Anemia Patients: A Retrospective Comparative Study.Clinical, cosmetic and investigational dentistry · 2026Article
- Emergency care for children with sickle cell disease: a focus on pain and fever.Expert review of hematology · 2025Review
- Article
- Curative Therapies for Hemophilias and Hemoglobinopathies in Adults: Immune, Gene, and Stem Cell Approaches in a Global Context.Biomedicines · 2025Review
- Current and future treatments for sickle cell disease: From hematopoietic stem cell transplantation to in vivo gene therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Review
- Article
- Hematopoietic Stem Cell Transplantation in Severe Pediatric Sickle Cell Disease: Outcome and long-term complications, Saudi experience at King Faisal Specialist Hospital, Riyadh, Saudi Arabia.Mediterranean journal of hematology and infectious diseases · 2025Article
- Genetically humanized phenylketonuria mouse model as a testing tool for human genome editing in fertilized eggs.Journal of inherited metabolic disease · 2025Article
- Late effects of hemopoietic stem cell transplant for sickle cell disease: monitoring and management.Expert review of hematology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 9 institutions in 1 country.
Lakshmanan KrishnamurtiAflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta and Department of Pediatrics, Emory University, Atlanta, Georgia.ORCID 0000-0003-3242-0037
Donna S NeubergDepartment of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, Massachusetts.
Keith M SullivanDepartment of Medicine, Division of Hematologic Malignancies and Cellular Therapies, Duke University Medical Center, Durham, North Carolina.
Naynesh R KamaniCenter for Cancer and Blood Disorders, Children's National Health System, Washington, DC.
Allistair AbrahamDivision of Hematology/Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0003-2019-0887
Federico CampigottoDepartment of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, Massachusetts.
Wandi ZhangDepartment of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, Massachusetts.
Thabat DahdoulDivision of Hematology/Oncology, Department of Medicine, University of Colorado, Denver, Colorado.
Laura De CastroDivision of Hematology/Oncology, Department of Pediatrics, City of Hope Hospital, Duarte, California.
Suhag ParikhDepartment of Medicine, Division of Hematologic Malignancies and Cellular Therapies, Duke University Medical Center, Durham, North Carolina.
Nitya BakshiAflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta and Department of Pediatrics, Emory University, Atlanta, Georgia.
Ann HaightAflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta and Department of Pediatrics, Emory University, Atlanta, Georgia.
Kathryn L HassellDivision of Hematology/Oncology, Department of Pediatrics, Children's Hospital of Richmond of Virginia Commonwealth University, Richmond, Virginia.
Rebekah LovingDivision of General Internal Medicine, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia.ORCID 0000-0001-8725-0376
Joseph RosenthalDivision of Stem Cell Transplantation and Immunotherapy, Department of Hematology and Medical Oncology, Emory University, Atlanta, Georgia.
Shannon L SmithAflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta and Department of Pediatrics, Emory University, Atlanta, Georgia.
Wally SmithDivision of Hematology/Oncology, Department of Pediatrics, UCSF Benioff Children's Hospital of Oakland, Oakland, California.
Marcus Spearman
Kristen StevensonDepartment of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, Massachusetts.
Catherine J WuDepartment of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, Massachusetts.
Christina WiedlDivision of Hematology/Oncology, Department of Pediatrics, UCSF Benioff Children's Hospital of Oakland, Oakland, California.
Edmund K WallerDivision of Stem Cell Transplantation and Immunotherapy, Department of Hematology and Medical Oncology, Emory University, Atlanta, Georgia.
Mark C WaltersDivision of Hematology/Oncology, Department of Pediatrics, UCSF Benioff Children's Hospital of Oakland, Oakland, California.
Emory University · USDana-Farber Cancer Institute · USUCSF Benioff Children's Hospital · USDuke Medical Center · USVirginia Commonwealth University · USChildren's National · USCity of Hope · USUniversity of Colorado Denver · USUniversity of Pittsburgh · US
Funding
Hematopoietic Stem Cell Transplantation for Young Adults with Sickle Cell Disease - Clinical Coordinating CenterU01HL128566 · NHLBI · YALE UNIVERSITY · PI KRISHNAMURTI, LAKSHMANAN, WALTERS, MARK C · 2015 to 2019
$7.3MHematopoietic Cell Therapy for Young Adults with Severe Sickle Cell DiseaseR34HL108761 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KRISHNAMURTI, LAKSHMANAN, WALTERS, MARK C · 2011 to 2013
$734kPilot study of Newborn screening for hemoglobinopathies in South Gujarat IndiaR03HD057740 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KRISHNAMURTI, LAKSHMANAN · 2008 to 2009
$166kNHLBI NIH HHS R34 HL108761NHLBI NIH HHS U01 HL128566NICHD NIH HHS R03 HD057740
Abstract
We conducted a multicenter pilot investigation of the safety and feasibility of bone marrow transplantation (BMT) in adults with severe sickle cell disease (SCD) (NCT 01565616) using a reduced toxicity preparative regimen of busulfan (13.2 mg/kg), fludarabine (175 mg/m
Indexed as
Anemia, Sickle CellBone Marrow TransplantationGraft vs Host DiseaseUnrelated DonorsAcute DiseaseAdolescentAdultAllograftsDisease-Free SurvivalFemaleHistocompatibility TestingHumansMaleProspective StudiesSurvival RateTime Factors
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
NCT04523376ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.