ArticleCerebellum (London, England)2019
Age-Dependent White Matter Characteristics of the Cerebellar Peduncles from Infancy Through Adolescence.
Article in Cerebellum (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed.
- Involvement of the Cerebellar Peduncles inInternational journal of molecular sciences · 2025Review
- Beyond motor learning: Insights from infant magnetic resonance imaging on the critical role of the cerebellum in behavioral development.Developmental cognitive neuroscience · 2025Review
- Consistent cerebellar pathway-cognition associations across pre-adolescents & young adults: a diffusion MRI study of 9000+ participants.bioRxiv : the preprint server for biology · 2025Article
- Age-related white matter alterations in children with neurofibromatosis type 1: a diffusion MRI tractography study.Frontiers in neuroscience · 2025Article
- Cerebello-Cerebral Pathways Contribute to Written Word Production.Neurobiology of language (Cambridge, Mass.) · 2025Article
- Structural Development of Speech Networks in Young Children: A Cross-Sectional Study.Neurobiology of language (Cambridge, Mass.) · 2025Article
- Early, low-dose hydrocortisone and near-term brain connectivity in extremely preterm infants.Pediatric research · 2024Article
- Microstructural Properties of the Cerebellar Peduncles in Children With Developmental Language Disorder.Neurobiology of language (Cambridge, Mass.) · 2024Article
- The Contributions of the Cerebellar Peduncles and the Frontal Aslant Tract in Mediating Speech Fluency.Neurobiology of language (Cambridge, Mass.) · 2024Article
- Associations of Behavioral Problems and White Matter Properties of the Cerebellar Peduncles in Boys and Girls Born Full Term and Preterm.Cerebellum (London, England) · 2023Article
- Association between attention-deficit/hyperactivity disorder symptom severity and white matter integrity moderated by in-scanner head motion.Translational psychiatry · 2022Article
- White Matter Microstructural Properties of the Cerebellar Peduncles Predict Change in Symptoms of Psychopathology in Adolescent Girls.Cerebellum (London, England) · 2022Article
- Tract profiles of the cerebellar peduncles in children who stutter.Brain structure & function · 2022Article
- Spatiotemporal changes in along-tract profilometry of cerebellar peduncles in cerebellar mutism syndrome.NeuroImage. Clinical · 2022Article
- Networking of the Human Cerebellum: From Anatomo-Functional Development to Neurosurgical Implications.Frontiers in neurology · 2022Review
- Speech rate association with cerebellar white-matter diffusivity in adults with persistent developmental stuttering.Brain structure & function · 2021Article
- A Focus on the Cerebellum: From Embryogenesis to an Age-Related Clinical Perspective.Frontiers in systems neuroscience · 2021Review
- Tractography of the Cerebellar Peduncles in Second- and Third-Trimester Fetuses.AJNR. American journal of neuroradiology · 2021Article
- Locomotor Adaptation Is Associated with Microstructural Properties of the Inferior Cerebellar Peduncle.Cerebellum (London, England) · 2020Article
- Neonatal white matter tract microstructure and 2-year language outcomes after preterm birth.NeuroImage. Clinical · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Cerebellum-cerebrum connections are essential for many motor and cognitive functions and cerebellar disorders are prevalent in childhood. The middle (MCP), inferior (ICP), and superior cerebellar peduncles (SCP) are the major white matter pathways that permit communication between the cerebellum and the cerebrum. Knowledge about the microstructural properties of these cerebellar peduncles across childhood is limited. Here, we report on a diffusion magnetic resonance imaging tractography study to describe age-dependent characteristics of the cerebellar peduncles in a cross-sectional sample of infants, children, and adolescents from newborn to 17 years of age (N = 113). Scans were collected as part of clinical care; participants were restricted to those whose scans showed no abnormal findings and whose history and exam had no risk factors for cerebellar abnormalities. A novel automated tractography protocol was applied. Results showed that mean tract-FA increased, while mean tract-MD decreased from infancy to adolescence in all peduncles. Rapid changes were observed in both diffusion measures in the first 24 months of life, followed by gradual change at older ages. The shape of the tract profiles was similar across ages for all peduncles. These data are the first to characterize the variability of diffusion properties both across and within cerebellar white matter pathways that occur from birth through later adolescence. The data represent a rich normative data set against which white matter alterations seen in children with posterior fossa conditions can be compared. Ultimately, the data will facilitate the identification of sensitive biomarkers of cerebellar abnormalities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.