ReviewPituitary2019
Pituitary dysfunction due to sports-related traumatic brain injury.
Review in Pituitary, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 36 citations in OpenAlex.
- Connecting the Dots: The Role of Pediatric Concussion on Pubertal Hormones and Psychological Health.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2026Article
- Impact of mild traumatic brain injury (mTBI) on sperm genome integrity: insights from a mouse model.Journal of endocrinological investigation · 2025Article
- Efficacy of biomarkers and imaging techniques for the diagnosis of traumatic brain injury: challenges and opportunities.Molecular and cellular biochemistry · 2025Review
- Progesterone and Estradiol Levels Associated with Concussion and Clinical Outcomes and Recovery in Female Athletes and Cadets.Medicine and science in sports and exercise · 2025Article
- Acute neuroendocrine changes after traumatic brain injury.Brain & spine · 2024Review
- Menstrual Cycle Patterns After Concussion in Adolescent Patients.The Journal of pediatrics · 2023Article
- Neuroendocrine Disruptions Following Head Injury.Current neurology and neuroscience reports · 2023Review
- A Calixarene Assembly Strategy of Combined Anti-Neuroinflammation and Drug Delivery Functions for Traumatic Brain Injury Therapy.Molecules (Basel, Switzerland) · 2022Article
- Hiding in Plain Sight: Factors Influencing the Neuroinflammatory Response to Sport-Related Concussion.Neurotrauma reports · 2022Article
- Management of hypopituitarism: a perspective from the Brazilian Society of Endocrinology and Metabolism.Archives of endocrinology and metabolism · 2021Review
- Growth hormone deficiency testing and treatment following mild traumatic brain injury.Scientific reports · 2021Article
- Endocrine rhythms and sport: it is time to take time into account.Journal of endocrinological investigation · 2019Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAfter traumatic brain injury was accepted as an important etiologic factor of pituitary dysfunction (PD), awareness of risk of developing PD following sports-related traumatic brain injury (SR-TBI) has also increased. However there are not many studies investigating PD following SR-TBIs yet. We aimed to summarize the data reported so far and to discuss screening algorithms and treatment strategies.
methodsRecent data on pituitary dysfunction after SR-TBIs is reviewed on basis of diagnosis, clinical perspectives, therapy, screening and possible prevention strategies.
resultsPituitary dysfunction is reported to occur in a range of 15-46.6% following SR-TBIs depending on the study design. Growth hormone is the most commonly reported pituitary hormone deficiency in athletes. Pituitary hormone deficiencies may occur during acute phase after head trauma, may improve with time or new deficiencies may develop during follow-up. Central adrenal insufficiency is the only and most critical impairment that requires urgent detection and replacement during acute phase. Decision on replacement of growth hormone and gonadal deficiencies should be individualized. Moreover these two hormones are abused by many athletes and a therapeutic use exemption from the league's drug policy may be required.
conclusionsEven mild and forgotten SR-TBIs may cause PD that may have distressing consequences in some cases if remain undiagnosed. More studies are needed to elucidate epidemiology and pathophysiology of PD after SR-TBIs. Also studies to establish screening algorithms for PD as well as strategies for prevention of SR-TBIs are urgently required.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.