ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2019
Prevalence of mental health conditions and pain in adults with skeletal dysplasia.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Burden and Treatment of Achondroplasia: A Systematic Literature Review.Advances in therapy · 2023Pooled it
- Functional Independence Assessment in Children and Adolescents with Achondroplasia: A Multicenter Cross-Sectional Study Using the WeeFIM Scale.Diagnostics (Basel, Switzerland) · 2025Article
- Mental health conditions, physical functioning, and health-related quality of life in adults with a skeletal dysplasia: a cross-sectional multinational study.Orphanet journal of rare diseases · 2025Article
- Physical Activity and Psychosocial Outcomes in Adults with Achondroplasia: An Exploratory Study.International journal of environmental research and public health · 2024Article
- European Achondroplasia Forum Practical Considerations for Following Adults with Achondroplasia.Advances in therapy · 2024Article
- Lifetime Impact Study for Achondroplasia (LISA): Findings from an observational and multinational study focused on health-related quality of life in individuals with achondroplasia in Latin America.Genetics in medicine open · 2024Article
- Interventions for improving clinical outcomes and health-related quality-of-life for people living with skeletal dysplasias: an evidence gap map.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Review
- Higher rates of non-skeletal complications and greater healthcare needs in achondroplasia compared to the general UK population: a matched cohort study using the CPRD database.Orphanet journal of rare diseases · 2023Article
- Poor mental health scores correlate with inferior outcomes following minimally invasive transforaminal lumbar interbody fusion.Acta neurochirurgica · 2023Article
- Optimising care and follow-up of adults with achondroplasia.Orphanet journal of rare diseases · 2022Article
- Optimising the diagnosis and referral of achondroplasia in Europe: European Achondroplasia Forum best practice recommendations.Orphanet journal of rare diseases · 2022Article
- International Consensus Statement on the diagnosis, multidisciplinary management and lifelong care of individuals with achondroplasia.Nature reviews. Endocrinology · 2022Review
- Functioning and equality according to International Classification of Functioning, Disability and Health (ICF) in people with skeletal dysplasia compared to matched control subjects - a cross-sectional survey study.BMC musculoskeletal disorders · 2020Article
- High prevalence of symptomatic spinal stenosis in Norwegian adults with achondroplasia: a population-based study.Orphanet journal of rare diseases · 2020Article
- Changes in skeletal dysplasia nosology.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe sought to examine the prevalence of depression and anxiety in adults with skeletal dysplasias, and to assess any correlations with pain.
methodsParticipation was via an anonymous REDCap survey, which consisted of sociodemographic questions followed by the brief pain inventory-short form (BPI-SF), patient health questionnaire-8 (PHQ-8), and generalized anxiety disorder-7 (GAD-7) questionnaires. These assessed pain, depression, and anxiety respectively.
resultsOf the 336 usable responses, 16.1% scored 10 or greater on the PHQ-8 consistent with current depression while 17.3% scored 10 or greater on the GAD-7 consistent with current anxiety. The majority of participants (76.2%) experienced pain, which was significantly associated with prior mental health diagnoses (p < 0.05). A total of 34% reported either a prior diagnosis of depression or scored 10 or greater on the PHQ-8, and 31% reported either a prior diagnosis of anxiety or scored 10 or greater on the GAD-7.
conclusionsThis study identified a substantial percentage of individuals with mental health concerns as well as pain in the adult skeletal dysplasia population. Further research is warranted to investigate barriers to service or treatment of mental health disorders as well as pain management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.