Evidence map›Paper›PMID 30637557›Full record

ArticleJournal of thrombosis and thrombolysis2019

Association study of miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms with venous thromboembolism in a Korean population.

Jung Oh Kim, Hyun Woo Kim, Hui Jeong An, Ok Joon Kim, Jisu Oh, So Young Chong, Won-Il Choi, Doyeun Oh, Nam Keun Kim

Abstract read
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In one paragraph

Article in Journal of thrombosis and thrombolysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jung Oh KimDepartment of Biomedical Science, College of Life Science, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam, South Korea.
Hyun Woo KimDepartment of Biomedical Science, College of Life Science, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam, South Korea.
Hui Jeong AnDepartment of Biomedical Science, College of Life Science, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam, South Korea.
Ok Joon KimDepartment of Neurology, CHA Bundang Medical Center, School of Medicine, CHA University, Seongnam, 13496, South Korea.
Jisu OhDepartment of Internal Medicine, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam, South Korea.
So Young ChongDepartment of Internal Medicine, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam, South Korea.
Won-Il ChoiDepartment of Internal Medicine, Keimyung University School of Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea.
Doyeun OhDepartment of Internal Medicine, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam, South Korea.
Nam Keun KimDepartment of Biomedical Science, College of Life Science, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam, South Korea. nkkim@cha.ac.kr.
CHA University · KRCHA University Bundang Medical Center · KRKeimyung University · KR

Funding

Korea Health Industry Development Institute HI15C1972010015Korea Health Industry Development Institute HI18C19990200National Research Foundation of Korea 2016R1D1A1B03930141
6 · The paper itself

Abstract

Despite much progress in microRNA (miRNA) research, information regarding the association between miRNAs and venous thromboembolism (VTE), especially in Asian patients, remains limited. This case-control study sought to determine the correlation between the presence of polymorphisms in the genes encoding the miRNAs miR-146a, miR-149, miR-196a2, miR-499, and VTE in Korean patients. We observed no statistically significant differences in the genotype frequency of miRNA polymorphisms between 300 control individuals and 203 VTE patients. However, we observed a significant association between three allelic combinations of miRNA polymorphisms and VTE risk. Overall, our findings suggest that specific miRNA polymorphisms are associated with the risk of VTE in a Korean population.

Indexed as

Polymorphism, Single NucleotideAdultAgedAsian PeopleCase-Control StudiesFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseHumansMaleMicroRNAsMiddle AgedPhenotypeRepublic of KoreaRisk AssessmentMicroRNAsMIRN146 microRNA, humanMIRN149 microRNA, humanMIRN196 microRNA, humanMIRN499 microRNA, humanDeep vein thrombosisMicroRNAPulmonary embolismSingle nucleotide polymorphism

Identifiers

PMID30637557
OpenAlexW2910069210

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.