Evidence map›Paper›PMID 30637548›Full record

ArticleDigestive diseases and sciences2019

Expression of Demethylase Genes, FTO and ALKBH1, Is Associated with Prognosis of Gastric Cancer.

Yue Li, Danyang Zheng, Fang Wang, Yuxia Xu, Hongyang Yu, Huizhong Zhang

Open access · hybridAbstract read
In one paragraph

Article in Digestive diseases and sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 1 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 1 synthesis or guideline pooled it, 115 citations in OpenAlex.

  1. Pooled it
  2. mBiology direct · 2026
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  4. Predictive Analysis and Validation of Critical Missense SNPs of theInternational journal of molecular sciences · 2025
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  17. Article
  18. NJournal of translational internal medicine · 2024
    Article
  19. Article
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yue LiState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China.
Danyang ZhengState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China.
Fang WangState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China.
Yuxia XuState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China.
Hongyang YuResearch Center of Special Operations, Army Special Operations Academy of PLA, Guangzhou, 510500, China.
Huizhong ZhangState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China. zhanghuizh@sysucc.org.cn.
Sun Yat-sen University Cancer Center · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundReversible N

aimsThis study was aimed at providing insights into the prognostic role of m

methodsKaplan-Meier (KM) plotter database and The Cancer Genome Atlas (TCGA) database were used to explore the prognostic significance of individual m

resultsAmong nine m

conclusionsAberrant expression of demethylase genes, FTO and ALKBH1, has a distinct prognostic value in GC patients, indicating that FTO and ALKBH1 may play vital roles in GC progression and metastasis.

Indexed as

AdenosineAgedAlkB Homolog 1, Histone H2a DioxygenaseAlpha-Ketoglutarate-Dependent Dioxygenase FTOBiomarkers, TumorDatabases, GeneticFemaleGene Expression Regulation, EnzymologicGene Expression Regulation, NeoplasticHumansMaleMiddle AgedProgression-Free SurvivalRisk FactorsRNA, MessengerRNA Processing, Post-TranscriptionalAdenosineALKBH1 protein, humanAlkB Homolog 1, Histone H2a DioxygenaseAlpha-Ketoglutarate-Dependent Dioxygenase FTOBiomarkers, TumorFTO protein, humanN-methyladenosineRNA, MessengerALKBH1FTOGastric cancerm6A-related genesPrognostic valuesTissue microarray (TMA)

Identifiers

PMID30637548
PMCPMC6522448
OpenAlexW2909321160

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.