Evidence map›Paper›PMID 30637539›Full record

ArticleApoptosis : an international journal on programmed cell death2019

Ultraspiracle-independent anti-apoptotic function of ecdysone receptors is required for the survival of larval peptidergic neurons via suppression of grim expression in Drosophila melanogaster.

Gyunghee Lee, Ritika Sehgal, Zixing Wang, Jae H Park

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Apoptosis : an international journal on programmed cell death, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Regional specialization, polyploidy, and seminal fluid transcripts in theProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  3. Review
  4. Reproductive Outbreaks ofInternational journal of molecular sciences · 2022
    Article
  5. Journal of developmental biology · 2021
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Gyunghee LeeDepartment of Biochemistry and Cellular and Molecular Biology and NeuroNet Research Center, University of Tennessee, Knoxville, TN, 37996, USA.
Ritika SehgalDepartment of Biochemistry and Cellular and Molecular Biology and NeuroNet Research Center, University of Tennessee, Knoxville, TN, 37996, USA.
Zixing WangUT-ORNL Graduate School of Genome Science and Technology Program, University of Tennessee, Knoxville, TN, 37996, USA.
Jae H ParkDepartment of Biochemistry and Cellular and Molecular Biology and NeuroNet Research Center, University of Tennessee, Knoxville, TN, 37996, USA. jhpark@utk.edu.ORCID 0000-0002-4846-2197
University of Tennessee at Knoxville · US

Funding

Mechanisms of the programmed cell death of post-embryonic neuronsR15GM114741 · NIGMS · UNIVERSITY OF TENNESSEE KNOXVILLE · PI PARK, JAE H · 2015 to 2016
$424k
NIGMS NIH HHS R15 GM114741
6 · The paper itself

Abstract

In Drosophila melanogaster a significant number of heterogenous larval neurons in the central nervous system undergo metamorphosis-associated programmed cell death, termed metamorphoptosis. Interestingly distinct groups of doomed larval neurons are eliminated at different metamorphic phases. Although ecdysone hormonal signaling via nuclear ecdysone receptors (EcRs) is known to orchestrate the neuronal metamorphoptosis, little is known about how this signaling controls such diverse neuronal responses. Crustacean cardioactive peptide (CCAP)-producing neurons in the ventral nerve cord are developmentally programmed to die shortly after adult emergence. In this study, we show that disruption of endogenous EcR function by ectopic expression of dominant negative forms of EcRs (EcR

Indexed as

AnimalsApoptosisCaspasesCell DeathCentral Nervous SystemDrosophila melanogasterDrosophila ProteinsGene Expression Regulation, DevelopmentalLarvaNeuronsNeuropeptidesProtein IsoformsReceptors, SteroidSignal TransductionCaspasescrustacean cardioactive peptideDrosophila Proteinsecdysone receptorNeuropeptidesProtein IsoformsReceptors, SteroidApoptosisCentral nervous systemEcdysone receptorGrimMetamorphoptosisPeptidergic neuronsUltraspiracle

Identifiers

PMID30637539
PMCPMC6486403
OpenAlexW2910803131

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.