ArticleInternational journal of bipolar disorders2019
Rumination related activity in brain networks mediating attentional switching in euthymic bipolar patients.
Article in International journal of bipolar disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 46 citations in OpenAlex.
- Machine learning reveals a multimodal, transdiagnostic signature of emotion dysregulation vulnerability across patients, offspring, and controls.Molecular psychiatry · 2026Article
- Characterizing gradients of functional connectome underpinning rumination and their alteration in depression.Translational psychiatry · 2026Article
- Hippocampal temporal dynamics and spatial heterogeneity unveil vulnerability markers in the offspring of bipolar patients.Bipolar disorders · 2025Article
- Dynamic functional hippocampal markers of residual depressive symptoms in euthymic bipolar disorder.Brain and behavior · 2023Article
- Differential patterns of default mode network activity associated with negative and positive rumination in bipolar disorder.Journal of affective disorders · 2023Article
- Neural Basis of Internal Attention in Adults with Pure and Comorbid ADHD.Journal of attention disorders · 2023Article
- Questionnaires based on natural language processing elicit immersive ruminative thinking in ruminators: Evidence from behavioral responses and EEG data.Frontiers in neuroscience · 2023Article
- Cognitive behavioral therapy (CBT), acceptance and commitment therapy (ACT), and Morita therapy (MT); comparison of three established psychotherapies and possible common neural mechanisms of psychotherapies.Journal of neural transmission (Vienna, Austria : 1996) · 2022Review
- Anxiety and depression severity in neuropsychiatric SLE are associated with perfusion and functional connectivity changes of the frontolimbic neural circuit: a resting-state f(unctional) MRI study.Lupus science & medicine · 2021Article
- Brain functional connectivity dynamics at rest in the aftermath of affective and cognitive challenges.Human brain mapping · 2021Article
- Dissociation Pattern in Default-Mode Network Homogeneity in Drug-Naive Bipolar Disorder.Frontiers in psychiatry · 2021Article
- Amplitude of low frequency fluctuations (ALFF) of spontaneous and induced rumination in major depression: An fNIRS study.Scientific reports · 2020Article
- The impact of rumination and anhedonia on daily social and occupational function.Journal of clinical and experimental neuropsychologyArticle
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Authors and funding
7 authors at 2 institutions in 1 country.
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Abstract
introductionMood disorder patients have a tendency to be more internally oriented, with difficulties in switching attentional focus, which might result in the generation of negative thoughts, such as rumination. The present study explored self-referential neural activity correlating with rumination tendency and attentional switching capacity in bipolar disorder.
methodsTwenty euthymic bipolar patients and twenty matched healthy controls underwent a novel introspection task of switching between internally and externally focused attention during a word processing task, while their brain activity was assessed using functional MRI.
resultsDuring internal focus, higher activity in self-related regions (mPFC, PCC) was found in euthymic bipolar patients as compared to controls, verifying the hypothesis of exaggerated recruitment of self-referential processes in bipolar subjects. Switching from internal to external focus revealed higher parahippocampal activity in patients as compared to controls, additionally more pronounced when switching away from negative as compared to positive self-referential information. Furthermore, rumination traits correlated with activity in PCC, subgenual and pregenual ACC, and bilateral anterior insula during repetition of internal focus, specifically when evaluating negative words. Finally, we used ACC subregions that correlated with tendency to ruminate as seeds for a whole brain connectivity analysis. Patients showed stronger connectivity between sgACC (seed), pgACC, dPFC, and anterior insula during internal focus, whereas pgACC (seed) was more strongly connected to parahippocampal gyrus when switching from internal to external focus.
conclusionsThese findings reveal an overactive rumination-related network whose activity is enhanced by negative information in euthymic bipolar patients, which could possibly contribute to impaired switching of thoughts away from internal attention.
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