ArticleNeuroradiology2019
Abnormal amplitude of low frequency fluctuation and functional connectivity in non-neuropsychiatric systemic lupus erythematosus: a resting-state fMRI study.
Article in Neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Disrupted Structure-Function Integration in Systemic Lupus Erythematosus and Its Impact on Cognitive Flexibility.Human brain mapping · 2025Article
- A multimodal MRI-based machine learning framework for classifying cognitive impairment in cerebral small vessel disease.Scientific reports · 2025Article
- Recent advances in the diagnosis and management of neuropsychiatric lupus.Nature reviews. Rheumatology · 2024Review
- Brain white matter microstructural alterations in patients with systemic lupus erythematosus: an automated fiber quantification study.Brain imaging and behavior · 2024Article
- Cerebral cortex functional reorganization in preschool children with congenital sensorineural hearing loss: a resting-state fMRI study.Frontiers in neurology · 2024Article
- Resting state functional connectivity in SLE patients and association with cognitive impairment and blood-brain barrier permeability.Rheumatology (Oxford, England) · 2023Article
- Structural and functional brain changes in X-linked Charcot-Marie-Tooth disease: insights from a multimodal neuroimaging study.Neuroradiology · 2022Article
- Disrupted resting-state interhemispheric functional connectivity in systemic lupus erythematosus patients with and without neuropsychiatric lupus.Neuroradiology · 2022Article
- Dynamic changes of amplitude of low-frequency in systemic lupus erythematosus patients with cognitive impairment.Frontiers in neuroscience · 2022Article
- Altered Temporal Dynamics of Brain Activity in Multiple-Frequency Bands in Non-Neuropsychiatric Systemic Lupus Erythematosus Patients with Inactive Disease.Neuropsychiatric disease and treatment · 2021Article
- Altered intrinsic brain activity and regional cerebral blood flow in patients with chronic neck and shoulder pain.Polish journal of radiology · 2020Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo explore the amplitude of low frequency fluctuation (ALFF) and functional connectivity (FC) disorders in non-neuropsychiatric systemic lupus erythematosus (non-NPSLE) patients by resting-state functional magnetic resonance imaging (rs-fMRI) and to study whether there are some clinical biomarkers that can be used to monitor the brain dysfunction.
methodsBased on the rs-fMRI data of 36 non-NPSLE patients and 30 normal controls, we first obtained the regions with abnormal ALFF signals in non-NPSLE patients. Then, by taking these areas as seed regions of interest (ROIs), we calculated the FC between ROIs and the whole brain to assess the network-level alterations. Finally, we correlated the altered values of ALFF and FC in non-NPSLE patients to some clinical data.
resultsCompared with the controls, non-NPSLE patients showed decreased ALFF in bilateral precuneus and increased ALFF in right cuneus and right calcarine fissure surrounding cortex (CAL). At network level, non-NPSLE patients exhibited higher FC between left precuneus and left middle occipital gyrus (MOG)/left superior occipital gyrus (SOG)/right middle frontal gyrus (MFG)/right dorsolateral superior frontal gyrus (SFGdor), and higher FC between right cuneus and bilateral precuneus/left posterior cingulate gyrus (PCG). The abnormal ALFF in right CAL and abnormal FC in right cuneus-left precuneus, right cuneus-right precuneus, and right cuneus-left PCG were correlated with the patients' certain clinical data (p < 0.05).
conclusionRs-fMRI is a promising tool for detecting the brain function disorders in non-NPSLE patients and to help understand the neurophysiological mechanisms. C4 and Systemic Lupus Erythematosus Disease Activity Index may be biomarkers of brain dysfunction in non-NPSLE patients.
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