Evidence map›Paper›PMID 30637435›Full record

ArticlePsychopharmacology2019

α5GABA

Cassie M Chandler, Jaren Reeves-Darby, Sherman A Jones, J Abigail McDonald, Guanguan Li, Md T Rahman, James M Cook, Donna M Platt

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. GABAergic compounds for the treatment of alcohol use disorder.International review of neurobiology · 2024
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Changes in the elimination and resurgence of alcohol-maintained behavior in rats and the effects of naltrexone.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Cassie M ChandlerGraduate Program in Neuroscience, University of Mississippi Medical Center, Jackson, MS, 39216, USA.
Jaren Reeves-DarbyDepartment of Psychiatry & Human Behavior, University of Mississippi Medical Center, 2500 North State St., Jackson, MS, 39216, USA.
Sherman A JonesDepartment of Psychiatry & Human Behavior, University of Mississippi Medical Center, 2500 North State St., Jackson, MS, 39216, USA.
J Abigail McDonaldDepartment of Psychiatry & Human Behavior, University of Mississippi Medical Center, 2500 North State St., Jackson, MS, 39216, USA.
Guanguan LiDepartment of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, 53211, USA.
Md T RahmanDepartment of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, 53211, USA.
James M CookDepartment of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, 53211, USA.
Donna M PlattGraduate Program in Neuroscience, University of Mississippi Medical Center, Jackson, MS, 39216, USA. dplatt@umc.edu.ORCID http://orcid.org/0000-0002-8369-9544
University of Mississippi Medical Center · USUniversity of Wisconsin–Milwaukee · US

Funding

GABAa receptor subtype mechanisms in nonhuman primatesR01AA016179 · NIAAA · UNIVERSITY OF MISSISSIPPI MED CTR · PI PLATT, DONNA M · 2006 to 2016
$3.2M
Development of new drugs for asthma by targeting GABA(A) receptors in the lungR01HL118561 · NHLBI · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2014 to 2017
$2.0M
Design of New Therapeutic Agents to Treat SchizophreniaR01MH096463 · NIMH · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2013 to 2017
$1.9M
Synthesis of Alpha2/Alpha3 GABA Agonists to Treat Neuropathic PainR01NS076517 · NINDS · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2012 to 2015
$1.3M
National Institute of Mental Health MH096463National Institute of Neurological Disorders and Stroke NS076517National Institute on Alcohol Abuse and Alcoholism AA016179NHLBI NIH HHS R01 HL118561NIAAA NIH HHS R01 AA016179NIMH NIH HHS R01 MH096463NINDS NIH HHS R01 NS076517
6 · The paper itself

Abstract

rationaleGABA

objectivesPharmacological approaches were used to probe the role of α5GABA

methodsFor reinstatement studies, rats were trained to self-administer alcohol under a fixed-ratio schedule in which responding was maintained by alcohol + sucrose deliveries and an alcohol-paired stimulus. Sweetened alcohol seeking was extinguished by eliminating solution deliveries and the sweetened alcohol-paired stimulus. During reinstatement tests, animals received pretreatments of an α5GABA

resultsL-655,708 attenuated reinstatement of sweetened alcohol seeking by alcohol + sucrose-paired cues; whereas sweetened alcohol-seeking behavior was augmented by QH-ii-066, albeit at different doses in different rats. Both L-655,708 and RY-023 selectively reduced alcohol + sucrose vs. sucrose self-administration. In contrast, naltrexone reduced both alcohol + sucrose and sucrose self-administration; whereas QH-ii-066 enhanced sucrose self-administration only.

conclusionsα5GABA

Indexed as

CuesAlcohol DrinkingAnimalsConditioning, OperantDrug Inverse AgonismEthanolExtinction, PsychologicalImidazolesMaleRatsRats, Sprague-DawleyReceptors, GABA-AReinforcement, PsychologySelf AdministrationSucroseSweetening AgentsEthanolGabra5 protein, ratImidazolesL 655,708Receptors, GABA-ASucroseSweetening AgentsAlcoholEthanolGABAA receptorsReinstatementSelf-administration

Identifiers

PMID30637435
PMCPMC6606346
OpenAlexW2908892547

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.