Evidence map›Paper›PMID 30637356›Full record

ArticleInvestigative and clinical urology2019

Prognostic significance of preoperative and follow-up neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with non-metastatic clear cell renal cell carcinoma.

Tae Woo Kim, Jung Hwan Lee, Kang Hee Shim, Seol Ho Choo, Jong Bo Choi, Hyun Soo Ahn, Se Joong Kim, Sun Il Kim

Open access · diamondAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Investigative and clinical urology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 5 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 5 syntheses or guidelines pooled it, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Tae Woo KimDepartment of Urology, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea.
Jung Hwan LeeDepartment of Urology, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea.
Kang Hee ShimDepartment of Urology, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea.
Seol Ho ChooDepartment of Urology, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea.
Jong Bo ChoiDepartment of Urology, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea.
Hyun Soo AhnDepartment of Urology, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea.
Se Joong KimDepartment of Urology, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea.
Sun Il KimDepartment of Urology, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea.ORCID 0000-0003-2674-983X
Ajou University Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the significance of preoperative and follow-up neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as prognostic factors for recurrence in patients with non-metastatic clear cell renal cell carcinoma (NMCCRCC). MATERIALS AND

methodsWe retrospectively reviewed the medical records of 309 patients with NMCCRCC who underwent radical or partial nephrectomy. The prognostic significance of various clinicopathological variables, preoperative NLR (pNLR) and PLR (pPLR), and NLR and PLR at recurrence or quasi-recurrence (rNLR and rPLR) for recurrence-free survival (RFS) was analyzed.

resultsAt mean follow-up of 93 months, 44 patients (14.2%) developed recurrence. In the univariate analysis, clinical presentation, tumor size, pathologic tumor stage, Fuhrman grade, pNLR, pPLR and rNLR were significant prognostic factors for RFS. In the multivariate analysis using pNLR and pPLR as continuous variables, tumor size, pathologic tumor stage and pPLR were independent prognostic factors for RFS. In the multivariate analysis using pNLR and pPLR as dichotomous variables, tumor size, pathologic tumor stage, Fuhrman grade and pNLR ≥1.7 were independent prognostic factors for RFS. In multivariate analyses using rNLR and rPLR, only tumor size and pathologic tumor stage were independent prognostic factors for RFS. In a subset of patients with recurrence or at least 42 months follow-up without recurrence, rNLR ≥1.9 was significantly associated with worse RFS, albeit without independent significance.

conclusionspNLR and pPLR are independent prognostic factors for RFS in patients with NMCCRCC. We propose that postoperative follow-up NLR of 1.9 and higher with one or more adverse clinicopathological factors should prompt radiologic evaluation for possible metastasis.

Indexed as

AdultAgedBlood PlateletsCarcinoma, Renal CellFemaleFollow-Up StudiesHumansKidney NeoplasmsLeukocyte CountLymphocyte CountLymphocytesMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingNephrectomyCarcinoma, renal cellInflammationPrognosis

Identifiers

PMID30637356
PMCPMC6318207
OpenAlexW2907809180

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.