ReviewJournal of dental anesthesia and pain medicine2018
Efficacy of dental local anesthetics: A review.
Review in Journal of dental anesthesia and pain medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Comparative efficacy and safety of bupivacaine versus articaine in third molar surgery: a systematic review and meta-analysis of randomized controlled trials.Acta odontologica Scandinavica · 2026Pooled it
- Pooled it
- Articaine provides a faster onset and longer duration of analgesia at lower supplemental injections compared to mepivacaine in third molar extractions.Oral and maxillofacial surgery · 2025Trial
- Investigating the relationship between psychophysiological parameters and behavioral patterns in children aged 7-10 years during dental treatment.BMC research notes · 2026Article
- Remifentanil Diminishes Stimulation-Induced Oral Tissue Blood Flow Changes.Anesthesia progress · 2026Article
- Comparing the Effect of 0.75% Ropivacaine and 2% Lidocaine on Intraoperative Bleeding and Postoperative Pain of Third Molar Surgery: A Double Blinded, Split Mouth Study.World journal of plastic surgery · 2025Article
- Comparison of the anesthetic effect of alkalized lidocaine versus non-alkalized lidocaine administered at a slow rate in mandibular primary molars.Journal of dental research, dental clinics, dental prospects · 2023Article
- Evaluation of Intraligamentous and Intraosseous Computer-Controlled Anesthetic Delivery Systems in Pediatric Dentistry: A Randomized Controlled Trial.Children (Basel, Switzerland) · 2022Article
- Article
- Influence of vehicle for calcium hydroxide on postoperative pain: a scoping review.Journal of dental anesthesia and pain medicine · 2022Article
- Effects of Diode Low-Level Laser Therapy of 810 Nm on Pulpal Anesthesia of Maxillary Premolars: A Double-Blind Randomized Clinical Trial.European endodontic journal · 2021Article
- Local Anesthetic Usage Among Dentists: German and International Data.Anesthesia progress · 2021Article
- Narrative review: the evidence for neurotoxicity of dental local anesthetics.Journal of dental anesthesia and pain medicine · 2020Review
- Resistance to local anesthesia in people with the Ehlers-Danlos Syndromes presenting for dental surgery.Journal of dental anesthesia and pain medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this review was to investigate the efficacy of dental local anesthetics, as it is well known among clinicians that local anesthesia may be challenging in some circumstances. Therefore, the focus of this review was on the efficacy of the products used in dental local anesthesia. In a Pubmed database literature search conducted, a total of 8646 articles were found to be related to dental local anesthetics. After having applied the inclusion criteria (human research, performed in the last 10 years, written in English language, and focus on dental local anesthetics) and having assessed the quality of the papers, 30 were deemed eligible for inclusion in this review. The conclusion of this review is that none of the dental local anesthetic amides provide 100% anesthesia. The problem appears to be more pronounced when mandibular teeth are attempted to be anaesthetized and especially if there is irreversible pulpitis involved. The authors conclude that this finding suggest exploration of more efficient techniques to administer dental local anesthesia, especially in the mandible, to establish a 100% efficacy, is needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.