Increased Risk of Heterotopic Ossification Following Revision Hip Arthroplasty for Periprosthetic Joint Infection.

Jorge Manrique, Pouya Alijanipour, Snir Heller, Michael Dove, Javad Parvizi

Open access · greenAbstract read

In one paragraph

Article in The archives of bone and joint surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it

0cells of the map it votes in

9citing papers in PubMed, 2 pooled it

1.4field-weighted citation impact, top 18% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

Periprosthetic joint infection and heterotopic ossification after total hip arthroplasty: systematic review and meta-analysis.BMC musculoskeletal disorders · 2025
Pooled it
Diagnostic and prognostic relevance of plain radiographs for periprosthetic joint infections of the hip: a literature review.European journal of medical research · 2024
Pooled it
Outcomes and associated factors of revision procedures after failed total ankle arthroplasty: a comparative cohort analysis.Archives of orthopaedic and trauma surgery · 2026
Article
Guarded Outcomes After Hip Hemiarthroplasty in Patients with Cerebral Palsy: Highlighting a Personalized Medicine Approach to Mitigate the Risk of Complications.Journal of personalized medicine · 2025
Article
Standardized protocol during acetabular fracture surgery results in low rates of heterotopic ossification.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024
Article
Heterotopic hip ossification resection: monocentric experiences of associated factors, outcomes, and complications.International orthopaedics · 2024
Article
Efficacy of Ibuprofen after Total Hip Arthroplasty to Prevent Heterotopic Ossification: Systematic Review and Meta-Analysis.Revista brasileira de ortopedia · 2023
Article
A Rare Case of Extremely Severe Heterotopic Ossification after Primary Total Hip Arthroplasty due to Persistent Mild Periprosthetic Joint Infection.Case reports in orthopedics · 2021
Article
Heterotopic Ossification in Orthopaedic and Trauma surgery: A Histopathological Ossification Score.Scientific reports · 2019
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jorge ManriqueResearch performed at The Rothman Institute at Thomas Jefferson University, Philadelphia, PA, USA.

Pouya AlijanipourResearch performed at The Rothman Institute at Thomas Jefferson University, Philadelphia, PA, USA.

Snir HellerResearch performed at The Rothman Institute at Thomas Jefferson University, Philadelphia, PA, USA.

Michael DoveResearch performed at The Rothman Institute at Thomas Jefferson University, Philadelphia, PA, USA.

Javad ParviziResearch performed at The Rothman Institute at Thomas Jefferson University, Philadelphia, PA, USA.

Thomas Jefferson University · USRothman Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo investigate whether surgery for Periprosthetic Joint Infection (PJI) of the hip, the number of procedures and their duration contribute to risk of Heterotopic Ossification formation.

methods56 patients with hip PJI undergoing one-stage (10) or two-stage (46) exchange arthroplasty were matched to 112 patients undergoing revision arthroplasty for aseptic failure based on age, gender, body mass index (BMI), surgical approach (all direct lateral) and date of surgery (2006-2013). Patients with Paget's disease and ankylosing spondylitis, or preoperative HO were excluded. Perioperative pain management included use of the anti-inflammatory medications in all patients without prophylactic radiotherapy. Six-month postoperative radiographs were reviewed based on Brooker classification.

resultsThe incidence of overall HO in PJI and aseptic groups was 84% (47/56) and 11% (12/112), respectively. High grade HO (grades 3 and 4) in PJI and aseptic groups were 25% (24/56) and 4% (4/112), respectively. PJI was an independent risk factor for HO in the multivariate analysis (odds ratio of 9.3, 95% CI: 2.9-29.9,

conclusionPatients undergoing surgical treatment of hip PJI seem to be at increased risk of developing HO compared to aseptic failure. HO prophylaxis regimens may be recommendable in eligible patients undergoing surgical intervention for PJI of the hip. LEVEL OF EVIDENCE: IV.

Indexed as

Heterotopic ossificationHipPeriprosthetic joint infectionRevision arthroplasty

Identifiers

PMID30637303

PMCPMC6310194

OpenAlexW2916678697

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.