Evidence map›Paper›PMID 30637094›Full record

ArticleJournal of extracellular vesicles2018

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.

Clotilde Théry, Kenneth W Witwer, Elena Aikawa, Maria Jose Alcaraz, Johnathon D Anderson, Ramaroson Andriantsitohaina, Anna Antoniou, Tanina Arab, Fabienne Archer, Georgia K Atkin-Smith and 372 more

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of extracellular vesicles, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 7,067 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7,067citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07273643 recruitingnot on this mapstarted 2026, after this paper: background citation

Characterization of Extracellular Vesicles From the Cord Blood of Extremely Preterm New Borns and Their Correlation With Severe Morbidity and Mortality

Typeobservational_patient_registrySponsorUniversity Hospital, MontpellierRan2026 to 2027Enrolled30ConditionsIntraventricular Hemorrhage, Pulmonary Hemorrhage, Death, ELGAN (22-28SA)ArmsVenous Cord blood sample, Arterial cord blood sample
NCT07402083 recruitingnot on this mapstarted 2026, after this paper: background citation

Administration of Extracellular Vesicles Isolated From Donor Human Milk as a Dietary Supplement for the Prevention of Necrotizing Enterocolitis in Preterm Infants

TypeobservationalSponsorInstituto de Investigacion Sanitaria La FeRan2026 to 2029Enrolled20ConditionsVery Preterm Infants (<32 Weeks of Gestation)ArmsDonor human milk extracellular vesicles (DHM-EVs)
3 · Its place in the literature

Who cites it

7,067 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Review
  7. CRISPR/Cas9 Delivery Using Extracellular Vesicles.Methods in molecular biology (Clifton, N.J.) · 2027
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7,007 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

382 authors.

Clotilde ThéryInstitut Curie, INSERM U932, PSL Research University, Paris, France.ORCID 0000-0001-8294-6884
Kenneth W WitwerThe Johns Hopkins University School of Medicine, Department of Molecular and Comparative Pathobiology, Baltimore, MD, USA.ORCID 0000-0003-1664-4233
Elena AikawaBrigham and Women's Hospital, Center for Interdisciplinary Cardiovascular Sciences, Boston, MA, USA.
Maria Jose AlcarazInteruniversity Research Institute for Molecular Recognition and Technological Development (IDM), University of Valencia, Polytechnic University of Valencia, Valencia, Spain.
Johnathon D AndersonUniversity of California, Davis, Department of Otolaryngology, Davis, CA, USA.
Ramaroson AndriantsitohainaINSERM U1063, Université d'Angers, CHU d'Angers, Angers, France.
Anna AntoniouGerman Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Tanina ArabUniversité de Lille, INSERM, U-1192, Laboratoire Protéomique, Réponse Inflammatoire et Spectrométrie de Masse - PRISM, Lille, France.
Fabienne ArcherUniversity of Lyon, INRA, EPHE, UMR754 Viral Infections and Comparative Pathology, Lyon, France.
Georgia K Atkin-SmithLa Trobe University, La Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, Bundoora, Australia.
D Craig AyreAtlantic Cancer Research Institute, Moncton, Canada.
Jean-Marie BachUniversité Bretagne Loire, Oniris, INRA, IECM, Nantes, France.
Daniel BachurskiUniversity of Cologne, Department of Internal Medicine I, Cologne, Germany.
Hossein BaharvandRoyan Institute for Stem Cell Biology and Technology, ACECR, Cell Science Research Center, Department of Stem Cells and Developmental Biology, Tehran, Iran.
Leonora BalajMassachusetts General Hospital, Department of Neurosurgery, Boston, MA, USA.
Shawn BaldacchinoUniversity of Malta, Department of Pathology, Msida, Malta.
Natalie N BauerUniversity of South Alabama, Department of Pharmacology, Center for Lung Biology, Mobile, AL, USA.
Amy A BaxterLa Trobe University, La Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, Bundoora, Australia.
Mary BebawyUniversity of Technology Sydney, Discipline of Pharmacy, Graduate School of Health, Sydney, Australia.
Carla BeckhamUniversity of Rochester, Rochester, NY, USA.
Apolonija Bedina ZavecNational Institute of Chemistry, Department of Molecular Biology and Nanobiotechnology, Ljubljana, Slovenia.
Abderrahim BenmoussaUniversité Laval, Centre de Recherche du CHU de Québec, Department of Infectious Diseases and Immunity, Quebec City, Canada.
Anna C BerardiOspedale Santo Spirito, Pescara, Italy.
Paolo BergeseCSGI - Research Center for Colloids and Nanoscience, Florence, Italy.
Ewa BielskaUniversity of Birmingham, Institute of Microbiology and Infection, Birmingham, UK.
Cherie BlenkironUniversity of Auckland, Auckland, New Zealand.
Sylwia Bobis-WozowiczJagiellonian University, Faculty of Biochemistry, Biophysics and Biotechnology, Department of Cell Biology, Kraków, Poland.
Eric BoilardUniversité Laval, Centre de Recherche du CHU de Québec, Department of Infectious Diseases and Immunity, Quebec City, Canada.
Wilfrid BoireauFEMTO-ST Institute, UBFC, CNRS, ENSMM, UTBM, Besançon, France.
Antonella BongiovanniInstitute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR) of Italy, Palermo, Italy.
Francesc E BorràsGermans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, REMAR-IVECAT Group, Badalona, Spain.
Steffi BoschUniversité Bretagne Loire, Oniris, INRA, IECM, Nantes, France.
Chantal M BoulangerINSERM UMR-S 970, Paris Cardiovascular Research Center, Paris, France.
Xandra BreakefieldMassachusetts General Hospital and Neuroscience Program, Harvard Medical School, Department of Neurology and Radiology, Boston, MA, USA.
Andrew M BreglioIcahn School of Medicine at Mount Sinai, New York City, NY, USA.
Meadhbh Á BrennanHarvard University, School of Engineering and Applied Sciences, Cambridge, MA, USA.
David R BrigstockNationwide Children's Hospital, Columbus, OH, USA.
Alain BrissonUMR-CBMN, CNRS-Université de Bordeaux, Bordeaux, France.
Marike Ld BroekmanHaaglanden Medical Center, Department of Neurosurgery, The Hague, The Netherlands.
Jacqueline F BrombergMemorial Sloan Kettering Cancer Center, Department of Medicine, New York City, NY, USA.
Paulina Bryl-GóreckaLund University, Department of Cardiology, Lund, Sweden.
Shilpa BuchUniversity of Nebraska Medical Center, Department of Pharmacology and Experimental Neuroscience, Omaha, NE, USA.
Amy H BuckUniversity of Edinburgh, Institute of Immunology & Infection Research, Edinburgh, UK.
Dylan BurgerKidney Research Centre, Ottawa, Canada.
Sara BusattoMayo Clinic, Department of Transplantation, Jacksonville, FL, USA.
Dominik BuschmannTechnical University of Munich, TUM School of Life Sciences Weihenstephan, Division of Animal Physiology and Immunology, Freising, Germany.
Benedetta BussolatiUniversity of Torino, Department of Molecular Biotechnology and Health Sciences, Torino, Italy.
Edit I BuzásMTA-SE Immuno-Proteogenomics Research Groups, Budapest, Hungary.
James Bryan ByrdUniversity of Michigan, Department of Medicine, Ann Arbor, MI, USA.
Giovanni CamussiUniversity of Torino, Department of Medical Sciences, Torino, Italy.
David Rf CarterOxford Brookes University, Department of Biological and Medical Sciences, Oxford, UK.
Sarah CarusoLa Trobe University, La Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, Bundoora, Australia.
Lawrence W ChamleyUniversity of Auckland, Department of Obstetrics and Gynaecology, Auckland, New Zealand.
Yu-Ting ChangNational Taiwan University Hospital, Department of Internal Medicine, Taipei, Taiwan.
Chihchen ChenNational Tsing Hua University, Department of Power Mechanical Engineering, Hsinchu, Taiwan.
Shuai ChenLeibniz Institute for Farm Animal Biology (FBN), Institute of Reproductive Biology, Dummerstorf, Germany.
Lesley ChengLa Trobe University, La Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, Bundoora, Australia.
Andrew R ChinCedars-Sinai Medical Center, Los Angeles, CA, USA.
Aled ClaytonCardiff University, School of Medicine, Cardiff, UK.
Stefano P ClericiUNICAMP, Institute of Biology, Campinas, Brazil.
Alex CocksCardiff University, School of Medicine, Cardiff, UK.
Emanuele CocucciThe Ohio State University, College of Pharmacy, Division of Pharmaceutics and Pharmaceutical Chemistry, Columbus, OH, USA.
Robert J CoffeyVanderbilt University Medical Center, Epithelial Biology Center, Department of Medicine, Nashville, TN, USA.
Anabela Cordeiro-da-SilvaUniversity of Porto, Faculty of Pharmacy (FFUP), IBMC/I3S, Porto, Portugal.
Yvonne CouchUniversity of Oxford, Radcliffe Department of Medicine, Acute Stroke Programme - Investigative Medicine, Oxford, UK.
Frank Aw CoumansAcademic Medical Centre of the University of Amsterdam, Department of Clinical Chemistry and Vesicle Observation Centre, Amsterdam, The Netherlands.
Beth CoyleThe University of Nottingham, School of Medicine, Children's Brain Tumour Research Centre, Nottingham, UK.
Rossella CrescitelliUniversity of Gothenburg, Institute of Medicine at Sahlgrenska Academy, Krefting Research Centre, Gothenburg, Sweden.
Miria Ferreira CriadoUniversity of São Paulo, Ribeirão Preto Medical School, Ribeirão Preto, Brazil.
Crislyn D'Souza-SchoreyUniversity of Notre Dame, Department of Biological Sciences, Notre Dame, IN, USA.
Saumya DasMassachusetts General Hospital, Boston, MA, USA.
Amrita Datta ChaudhuriThe Johns Hopkins University School of Medicine, Department of Neurology, Baltimore, MD, USA.
Paola de CandiaIRCCS MultiMedica, Milan, Italy.
Eliezer F De SantanaThe Sociedade Beneficente Israelita Brasileira Albert Einstein, São Paulo, Brazil.
Olivier De WeverCancer Research Institute Ghent, Ghent, Belgium.
Hernando A Del PortilloInstitució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
Tanguy DemaretUniversité Catholique de Louvain, Institut de Recherche Expérimentale et Clinique (IREC), Laboratory of Pediatric Hepatology and Cell Therapy, Brussels, Belgium.
Sarah DevilleUniversiteit Hasselt, Diepenbeek, Belgium.
Andrew DevittAston University, School of Life & Health Sciences, Birmingham, UK.
Bert DhondtCancer Research Institute Ghent, Ghent, Belgium.
Dolores Di VizioCedars-Sinai Medical Center, Los Angeles, CA, USA.
Lothar C DieterichETH Zurich, Institute of Pharmaceutical Sciences, Zurich, Switzerland.
Vincenza DoloUniversity of L'Aquila, Department of Life, Health and Environmental Sciences, L'Aquila, Italy.
Ana Paula Dominguez RubioUniversidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Buenos Aires, Argentina.
Massimo DominiciTPM of Mirandola, Mirandola, Italy.
Mauricio R DouradoUniversity of Campinas, Piracicaba Dental School, Department of Oral Diagnosis, Piracicaba, Brazil.
Tom Ap DriedonksUtrecht University, Faculty of Veterinary Medicine, Department of Biochemistry and Cell Biology, Utrecht, The Netherlands.
Filipe V DuarteExogenus Therapeutics, Cantanhede, Portugal.
Heather M DuncanMcGill University, Division of Experimental Medicine, Montreal, Canada.
Ramon M EichenbergerJames Cook University, Australian Institute of Tropical Health and Medicine, Centre for Biodiscovery and Molecular Development of Therapeutics, Cairns, Australia.
Karin EkströmUniversity of Gothenburg, Institute of Clinical Sciences at Sahlgrenska Academy, Department of Biomaterials, Gothenburg, Sweden.
Samir El AndaloussiEvox Therapeutics Limited, Oxford, UK.
Celine Elie-CailleFEMTO-ST Institute, UBFC, CNRS, ENSMM, UTBM, Besançon, France.
Uta ErdbrüggerUniversity of Virginia Health System, Department of Medicine, Division of Nephrology, Charlottesville, VA, USA.
Juan M Falcón-PérezCIC bioGUNE, CIBERehd, Exosomes Laboratory & Metabolomics Platform, Derio, Spain.
Farah FatimaUniversity of São Paulo, Ribeirão Preto Medical School, Department of Pathology and Forensic Medicine, Ribeirão Preto, Brazil.
Jason E FishToronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Miguel Flores-BellverUniversity of Colorado, School of Medicine, Department of Ophthalmology, Cell Sight-Ocular Stem Cell and Regeneration Program, Aurora, CO, USA.
András FörsönitsSemmelweis University, Department of Genetics, Cell- and Immunobiology, Budapest, Hungary.
Annie Frelet-BarrandFEMTO-ST Institute, UBFC, CNRS, ENSMM, UTBM, Besançon, France.
Fabia FrickeGerman Cancer Research Center (DKFZ), Clinical Cooperation Unit Applied Tumor Biology, Heidelberg, Germany.
Gregor FuhrmannHelmholtz-Centre for Infection Research, Braunschweig, Germany.
Susanne GabrielssonKarolinska Institute, Department of Medicine Solna, Division for Immunology and Allergy, Stockholm, Sweden.
Ana Gámez-ValeroGermans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, REMAR-IVECAT Group, Badalona, Spain.
Chris GardinerUniversity College London, London, UK.
Kathrin GärtnerHelmholtz Center Munich German Research Center for Environmental Health, Research Unit Gene Vectors, Munich, Germany.
Raphael GaudinINSERM U1110, Strasbourg, France.
Yong Song GhoPOSTECH (Pohang University of Science and Technology), Department of Life Sciences, Pohang, South Korea.
Bernd GiebelUniversity Hospital Essen, University Duisburg-Essen, Institute for Transfusion Medicine, Essen, Germany.
Caroline GilbertUniversité Laval, Centre de Recherche du CHU de Québec, Department of Infectious Diseases and Immunity, Quebec City, Canada.
Mario GimonaParacelsus Medical University, GMP Unit, Salzburg, Austria.
Ilaria GiustiUniversity of L'Aquila, Department of Life, Health and Environmental Sciences, L'Aquila, Italy.
Deborah Ci GoberdhanUniversity of Oxford, Department of Physiology, Anatomy and Genetics, Oxford, UK.
André GörgensEvox Therapeutics Limited, Oxford, UK.
Sharon M GorskiBC Cancer, Canada's Michael Smith Genome Sciences Centre, Vancouver, Canada.
David W GreeningLa Trobe University, La Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, Bundoora, Australia.
Julia Christina GrossUniversity Medical Center Göttingen, Developmental Biochemistry, Göttingen, Germany.
Alice GualerziIRCCS Fondazione Don Carlo Gnocchi, Laboratory of Nanomedicine and Clinical Biophotonics (LABION), Milan, Italy.
Gopal N GuptaLoyola University Chicago, Department of Urology, Maywood, IL, USA.
Dakota GustafsonUniversity of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, Canada.
Aase HandbergAalborg University Hospital, Department of Clinical Biochemistry, Aalborg, Denmark.
Reka A HarasztiUniversity of Massachusetts Medical School, RNA Therapeutics Institute, Worcester, MA, USA.
Paul HarrisonUniversity of Birmingham, Birmingham, UK.
Hargita HegyesiSemmelweis University, Department of Genetics, Cell- and Immunobiology, Budapest, Hungary.
An HendrixCancer Research Institute Ghent, Ghent, Belgium.
Andrew F HillLa Trobe University, La Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, Bundoora, Australia.
Fred H HochbergScintillon Institute, La Jolla, CA, USA.
Karl F HoffmannAberystwyth University, Institute of Biological, Environmental and Rural Sciences (IBERS), Aberystwyth, United Kingdom.
Beth HolderImperial College London, London, UK.
Harry HolthoferUniversity Clinic Eppendorf, Hamburg, Germany.
Baharak HosseinkhaniHasselt University, Biomedical Research Institute (BIOMED), Department of Medicine and Life Sciences, Hasselt, Belgium.
Guoku HuUniversity of Nebraska Medical Center, Department of Pharmacology and Experimental Neuroscience, Omaha, NE, USA.
Yiyao HuangNanfang Hospital, Southern Medical University, Department of Clinical Laboratory Medicine, Guangzhou, China.
Veronica HuberFondazione IRCCS Istituto Nazionale dei Tumori, Unit of Immunotherapy of Human Tumors, Milan, Italy.
Stuart HuntThe University of Sheffield, Sheffield, UK.
Ahmed Gamal-Eldin IbrahimCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA.
Tsuneya IkezuBoston University School of Medicine, Boston, MA, USA.
Jameel M InalUniversity of Hertfordshire, School of Life and Medical Sciences, Biosciences Research Group, Hatfield, UK.
Mustafa IsinIstanbul University Oncology Institute, Basic Oncology Department, Istanbul, Turkey.
Alena IvanovaGerman Cancer Research Center (DKFZ), Division Signaling and Functional Genomics, Heidelberg, Germany.
Hannah K JacksonThe University of Nottingham, School of Medicine, Children's Brain Tumour Research Centre, Nottingham, UK.
Soren JacobsenCopenhagen Lupus and Vasculitis Clinic, Section 4242 - Rigshospitalet, Copenhagen, Denmark.
Steven M JayUniversity of Maryland, Fischell Department of Bioengineering, College Park, MD, USA.
Muthuvel JayachandranMayo Clinic, College of Medicine, Department of Physiology and Biomedical Engineering, Rochester, MN, USA.
Guido JensterDepartment of Urology, Rotterdam, The Netherlands.
Lanzhou JiangLa Trobe University, La Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, Bundoora, Australia.
Suzanne M JohnsonUniversity of Manchester, Division of Cancer Sciences, Manchester Cancer Research Centre, Manchester, UK.
Jennifer C JonesNational Institutes of Health, National Cancer Institute, Center for Cancer Research, Bethesda, MD, USA.
Ambrose JongChildren's Hospital of Los Angeles, Los Angeles, CA, USA.
Tijana Jovanovic-TalismanCity of Hope Comprehensive Cancer Center, Beckman Research Institute, Department of Molecular Medicine, Duarte, CA, USA.
Stephanie JungGerman Research Center for Environmental Health, Institute for Virology, Munich, Germany.
Raghu KalluriUniversity of Texas MD Anderson Cancer Center, Department of Cancer Biology, Metastasis Research Center, Houston, TX, USA.
Shin-Ichi KanoThe Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, MD, USA.
Sukhbir KaurNational Institutes of Health, National Cancer Institute, Center for Cancer Research, Laboratory of Pathology, Bethesda, MD, USA.
Yumi KawamuraNational Cancer Center Research Institute, Tokyo, Japan.
Evan T KellerUniversity of Michigan, Biointerfaces Institute, Ann Arbor, MI, USA.
Delaram KhamariSemmelweis University, Department of Genetics, Cell- and Immunobiology, Budapest, Hungary.
Elena KhomyakovaÉcole normale supérieure, Paris, France.
Anastasia KhvorovaUniversity of Massachusetts Medical School, RNA Therapeutics Institute, Worcester, MA, USA.
Peter KierulfOslo University Hospital, Department of Medical Biochemistry, Blood Cell Research Group, Oslo, Norway.
Kwang Pyo KimKyung Hee University, Department of Applied Chemistry, Yongin, Korea.
Thomas KislingerPrincess Margaret Cancer Centre, University Health Network, Toronto, Canada.
Mikael KlingebornDuke University, Department of Ophthalmology, Durham, NC, USA.
David J KlinkeWest Virginia University, Department of Chemical and Biomedical Engineering and WVU Cancer Institute, Morgantown, WV, USA.
Miroslaw KornekGerman Armed Forces Central Hospital, Department of General, Visceral and Thoracic Surgery, Koblenz, Germany.
Maja M KosanovićUniversity of Belgrade, Institute for the Application of Nuclear Energy, INEP, Belgrade, Serbia.
Árpád Ferenc KovácsSemmelweis University, Department of Genetics, Cell- and Immunobiology, Budapest, Hungary.
Eva-Maria Krämer-AlbersUniversity of Mainz, Institute of Developmental Biology and Neurobiology, Mainz, Germany.
Susanne KrasemannUniversity Medical Center Hamburg-Eppendorf, Institute of Neuropathology, Hamburg, Germany.
Mirja KrauseHudson Institute of Medical Research, Melbourne, Australia.
Igor V KurochkinCentral Research Laboratories, Sysmex Co., Kobe, Japan.
Gina D KusumaHudson Institute of Medical Research, Melbourne, Australia.
Sören KuypersHasselt University, Biomedical Research Institute (BIOMED), Hasselt, Belgium.
Saara LaitinenFinnish Red Cross Blood Service, Research and Development, Helsinki, Finland.
Scott M LangevinCincinnati Cancer Center, Cincinnati, OH, USA.
Lucia R LanguinoThomas Jefferson University, Sidney Kimmel Medical School, Department of Cancer Biology, Philadelphia, PA, USA.
Joanne LanniganUniversity of Virginia, Flow Cytometry Core, School of Medicine, Charlottesville, VA, USA.
Cecilia LässerUniversity of Gothenburg, Institute of Medicine at Sahlgrenska Academy, Krefting Research Centre, Gothenburg, Sweden.
Louise C LaurentUniversity of California, San Diego, Department of Obstetrics, Gynecology, and Reproductive Sciences, La Jolla, CA, USA.
Gregory LavieuInstitut Curie, INSERM U932, PSL Research University, Paris, France.
Elisa Lázaro-IbáñezAstraZeneca, Discovery Sciences, IMED Biotech Unit, Gothenburg, Sweden.
Soazig Le LayINSERM U1063, Université d'Angers, CHU d'Angers, Angers, France.
Myung-Shin LeeEulji University, School of Medicine, Daejeon, South Korea.
Yi Xin Fiona LeeGenome Institute of Singapore, ASTAR, Singapore.
Debora S LemosFederal University of Paraná, Department of Genetics, Human Molecular Genetics Laboratory, Curitiba, Brazil.
Metka LenassiUniversity of Ljubljana, Faculty of Medicine, Institute of Biochemistry, Ljubljana, Slovenia.
Aleksandra LeszczynskaUniversity of California, San Diego, Department of Pediatrics, San Diego, CA, USA.
Isaac Ts LiUniversity of British Columbia Okanagan, Kelowna, Canada.
Ke LiaoUniversity of Nebraska Medical Center, Department of Pharmacology and Experimental Neuroscience, Omaha, NE, USA.
Sten F LibregtsUniversity of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Department of Medicine, Cambridge NIHR BRC Cell Phenotyping Hub, Cambridge, UK.
Erzsebet LigetiSemmelweis University, Department of Physiology, Budapest, Hungary.
Rebecca LimHudson Institute of Medical Research, Melbourne, Australia.
Sai Kiang LimInstitute of Medical Biology (IMB), Agency for Science and Technology (ASTAR), Singapore.
Aija LinēLatvian Biomedical Research and Study Centre, Riga, Latvia.
Karen LinnemannstönsUniversity Medical Center Göttingen, Developmental Biochemistry, Göttingen, Germany.
Alicia LlorenteOslo University Hospital-The Norwegian Radium Hospital, Institute for Cancer Research, Department of Molecular Cell Biology, Oslo, Norway.
Catherine A LombardUniversité Catholique de Louvain, Institut de Recherche Expérimentale et Clinique (IREC), Laboratory of Pediatric Hepatology and Cell Therapy, Brussels, Belgium.
Magdalena J LorenowiczUtrecht University, University Medical Center Utrecht, Center for Molecular Medicine & Regenerative Medicine Center, Utrecht, The Netherlands.
Ákos M LörinczSemmelweis University, Department of Physiology, Budapest, Hungary.
Jan LötvallUniversity of Gothenburg, Institute of Medicine at Sahlgrenska Academy, Krefting Research Centre, Gothenburg, Sweden.
Jason LovettStellenbosch University, Department of Physiological Sciences, Stellenbosch, South Africa.
Michelle C LowryTrinity College Dublin, School of Pharmacy and Pharmaceutical Sciences, Panoz Institute & Trinity Biomedical Sciences Institute, Dublin, Ireland.
Xavier LoyerINSERM UMR-S 970, Paris Cardiovascular Research Center, Paris, France.
Quan LuHarvard University, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Barbara LukomskaMossakowski Medical Research Centre, NeuroRepair Department, Warsaw, Poland.
Taral R LunavatK.G. Jebsen Brain Tumor Research Centre, Department of Biomedicine, University of Bergen, Bergen, Norway.
Sybren Ln MaasUtrecht University, University Medical Center Utrecht, Department of Neurosurgery, Brain Center Rudolf Magnus, Institute of Neurosciences, Utrecht, The Netherlands.
Harmeet MalhiMayo Clinic, Rochester, MN, USA.
Antonio MarcillaUniversitat de València, Departament de Farmàcia i Tecnologia Farmacèutica i Parasitologia, Àrea de Parasitologia, Valencia, Spain.
Jacopo MarianiUniversità degli Studi di Milano, Department of Clinical Sciences and Community Health, EPIGET LAB, Milan, Italy.
Javier MariscalCedars-Sinai Medical Center, Los Angeles, CA, USA.
Elena S Martens-UzunovaDepartment of Urology, Rotterdam, The Netherlands.
Lorena Martin-JaularInstitut Curie, INSERM U932, PSL Research University, Paris, France.
M Carmen MartinezINSERM U1063, Université d'Angers, CHU d'Angers, Angers, France.
Vilma Regina MartinsA.C.Camargo Cancer Center, São Paulo, Brazil.
Mathilde MathieuInstitut Curie, INSERM U932, PSL Research University, Paris, France.
Suresh MathivananLa Trobe University, La Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, Bundoora, Australia.
Marco MaugeriUniversity of Gothenburg, Sahlgrenska Academy, Department of Rheumatology and Inflammation Research, Gothenburg, Sweden.
Lynda K McGinnisUniversity of Southern California, Los Angeles, CA, USA.
Mark J McVeySickKids Hospital, Department of Anesthesia and Pain Medicine, Toronto, Canada.
David G MeckesFlorida State University College of Medicine, Department of Biomedical Sciences, Tallahassee, FL, USA.
Katie L MeehanThe School of Biomedical Sciences, University of Western Australia, Perth, Australia.
Inge MertensUniversity of Antwerp, Centre for Proteomics, Antwerp, Belgium.
Valentina R MinciacchiGeorg-Speyer-Haus Institute for Tumor Biology and Experimental Therapy, Frankfurt, Germany.
Andreas MöllerQIMR Berghofer Medical Research Institute, Herston, Australia.
Malene Møller JørgensenAalborg University Hospital, Department of Clinical Immunology, Aalborg, Denmark.
Aizea Morales-KastresanaNational Institutes of Health, National Cancer Institute, Center for Cancer Research, Bethesda, MD, USA.
Jess MorhayimErasmus MC, Rotterdam, The Netherlands.
François MullierNamur Thrombosis and Hemostasis Center (NTHC), NARILIS, Namur, Belgium.
Maurizio MuracaUniversity of Padova, Department of Women's and Children's Health, Padova, Italy.
Luca MusanteUniversity of Virginia Health System, Department of Medicine, Division of Nephrology, Charlottesville, VA, USA.
Veronika MussackTechnical University of Munich, TUM School of Life Sciences Weihenstephan, Division of Animal Physiology and Immunology, Freising, Germany.
Dillon C MuthThe Johns Hopkins University School of Medicine, Department of Molecular and Comparative Pathobiology, Baltimore, MD, USA.
Kathryn H MyburghStellenbosch University, Department of Physiological Sciences, Stellenbosch, South Africa.
Tanbir NajranaBrown University, Women and Infants Hospital, Providence, RI, USA.
Muhammad NawazUniversity of Gothenburg, Sahlgrenska Academy, Department of Rheumatology and Inflammation Research, Gothenburg, Sweden.
Irina NazarenkoGerman Cancer Consortium (DKTK), Partner Site Freiburg and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Peter NejsumAarhus University, Department of Clinical Medicine, Aarhus, Denmark.
Christian NeriSorbonne Université, Centre National de la Recherche Scientifique, Research Unit Biology of Adaptation and Aging (B2A), Team Compensation in Neurodegenerative and Aging (Brain-C), Paris, France.
Tommaso NeriUniversity of Pisa, Centro Dipartimentale di Biologia Cellulare Cardio-Respiratoria, Pisa, Italy.
Rienk NieuwlandAcademic Medical Centre of the University of Amsterdam, Department of Clinical Chemistry and Vesicle Observation Centre, Amsterdam, The Netherlands.
Leonardo NimrichterUniversidade Federal do Rio de Janeiro, Instituto de Microbiologia, Rio de Janeiro, Brazil.
John P NolanScintillon Institute, La Jolla, CA, USA.
Esther Nm Nolte-'t HoenUtrecht University, Faculty of Veterinary Medicine, Department of Biochemistry and Cell Biology, Utrecht, The Netherlands.
Nicole Noren HootenNational Institutes of Health, National Institute on Aging, Baltimore, MD, USA.
Lorraine O'DriscollTrinity College Dublin, School of Pharmacy and Pharmaceutical Sciences, Panoz Institute & Trinity Biomedical Sciences Institute, Dublin, Ireland.
Tina O'GradyUniversity of Liège, GIGA-R(MBD), PSI Laboratory, Liège, Belgium.
Ana O'LoghlenQueen Mary University of London, Blizard Institute, Epigenetics & Cellular Senescence Group, London, UK.
Takahiro OchiyaNational Cancer Center Research Institute, Division of Molecular and Cellular Medicine, Tokyo, Japan.
Martin OlivierMcGill University, The Research Institute of the McGill University Health Centre, Montreal, Canada.
Alberto OrtizIIS-Fundacion Jimenez Diaz-UAM, Department of Nephrology and Hypertension, Madrid, Spain.
Luis A OrtizGraduate School of Public Health at the University of Pittsburgh, Division of Occupational and Environmental Medicine, Pittsburgh, PA, USA.
Xabier OsteikoetxeaAstraZeneca, Discovery Sciences, IMED Biotech Unit, Cambridge, UK.
Ole ØstergaardStatens Serum Institut, Department of Autoimmunology and Biomarkers, Copenhagen, Denmark.
Matias OstrowskiUniversity of Buenos Aires, Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Buenos Aires, Argentina.
Jaesung ParkPOSTECH (Pohang University of Science and Technology), Department of Life Sciences, Pohang, South Korea.
D Michiel PegtelAmsterdam University Medical Centers, Department of Pathology, Amsterdam, The Netherlands.
Hector PeinadoSpanish National Cancer Research Center (CNIO), Molecular Oncology Programme, Microenvironment and Metastasis Laboratory, Madrid, Spain.
Francesca PerutIRCCS - Istituto Ortopedico Rizzoli, Laboratory for Orthopaedic Pathophysiology and Regenerative Medicine, Bologna, Italy.
Michael W PfafflTechnical University of Munich, TUM School of Life Sciences Weihenstephan, Division of Animal Physiology and Immunology, Freising, Germany.
Donald G PhinneyThe Scripps Research Institute-Scripps Florida, Department of Molecular Medicine, Jupiter, FL, USA.
Bartijn Ch PietersRadboud University Medical Center, Department of Rheumatology, Nijmegen, The Netherlands.
Ryan C PinkOxford Brookes University, Department of Biological and Medical Sciences, Oxford, UK.
David S PisetskyDuke University Medical Center, Departments of Medicine and Immunology, Durham, NC, USA.
Elke Pogge von StrandmannPhilipps University Marburg, Experimental Tumor Biology, Marburg, Germany.
Iva PolakovicovaPontificia Universidad Católica de Chile, Advanced Center for Chronic Diseases (ACCDiS), Santiago, Chile.
Ivan Kh PoonLa Trobe University, La Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, Bundoora, Australia.
Bonita H PowellThe Johns Hopkins University School of Medicine, Department of Molecular and Comparative Pathobiology, Baltimore, MD, USA.
Ilaria PradaCNR Institute of Neuroscience, Milan, Italy.
Lynn PulliamUniversity of California, San Francisco, CA, USA.
Peter QuesenberryThe Warren Alpert Medical School of Brown University, Department of Medicine, Providence, RI, USA.
Annalisa RadeghieriCSGI - Research Center for Colloids and Nanoscience, Florence, Italy.
Robert L RaffaiDepartment of Veterans Affairs, San Francisco, CA, USA.
Stefania RaimondoUniversity of Palermo, Department of Biopathology and Medical Biotechnologies, Palermo, Italy.
Janusz RakMcGill University, Montreal, Canada.
Marcel I RamirezInstituto Oswaldo Cruz, Rio de Janeiro, Brazil.
Graça RaposoInstitut Curie, CNRS UMR144, PSL Research University, Paris, France.
Morsi S RayyanUniversity of Michigan Medical School, Ann Arbor, MI, USA.
Neta Regev-RudzkiWeizmann Institute of Science, Department of Biomolecular Sciences, Rehovot, Israel.
Franz L RicklefsUniversity Medical Center Hamburg-Eppendorf, Department of Neurosurgery, Hamburg, Germany.
Paul D RobbinsUniversity of Minnesota Medical School, Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, Minneapolis, MN, USA.
David D RobertsNational Institutes of Health, National Cancer Institute, Center for Cancer Research, Laboratory of Pathology, Bethesda, MD, USA.
Silvia C RodriguesCNC, Coimbra, Portugal.
Eva RohdeParacelsus Medical University, Department of Transfusion Medicine, Salzburg, Austria.
Sophie RomeUniversity of Lyon, Lyon-Sud Faculty of Medicine, CarMeN Laboratory (UMR INSERM 1060-INRA 1397), Pierre-Bénite, France.
Kasper Ma RouschopMaastricht University, GROW, School for Oncology and Developmental Biology, Maastricht Radiation Oncology (MaastRO) Lab, Maastricht, The Netherlands.
Aurelia RughettiSapienza University of Rome, Department of Experimental Medicine, Rome, Italy.
Ashley E RussellWest Virginia University, Morgantown, WV, USA.
Paula SaáAmerican Red Cross, Scientific Affairs, Gaithersburg, MD, USA.
Susmita SahooIcahn School of Medicine at Mount Sinai, Department of Medicine, Cardiology, New York City, NY, USA.
Edison Salas-HuenuleoAdvanced Center for Chronic Diseases, Santiago, Chile.
Catherine SánchezClínica las Condes, Extracellular Vesicles in Personalized Medicine Group, Santiago, Chile.
Julie A SaugstadOregon Health & Science University, Department of Anesthesiology & Perioperative Medicine, Portland, OR, USA.
Meike J SaulTechnische Universität Darmstadt, Department of Biology, Darmstadt, Germany.
Raymond M SchiffelersUniversity Medical Center Utrecht, Laboratory for Clinical Chemistry & Hematology, Utrecht, The Netherlands.
Raphael SchneiderUniversity of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, Canada.
Tine Hiorth SchøyenThe Johns Hopkins University School of Medicine, Department of Molecular and Comparative Pathobiology, Baltimore, MD, USA.
Aaron ScottUniversity of Bristol, Bristol, UK.
Eriomina ShahajFondazione IRCCS Istituto Nazionale dei Tumori, Unit of Immunotherapy of Human Tumors, Milan, Italy.
Shivani SharmaUniversity of California, Los Angeles, California NanoSystems Institute, Los Angeles, CA, USA.
Olga ShatnyevaAstraZeneca, Discovery Sciences, IMED Biotech Unit, Gothenburg, Sweden.
Faezeh ShekariRoyan Institute for Stem Cell Biology and Technology, ACECR, Cell Science Research Center, Department of Stem Cells and Developmental Biology, Tehran, Iran.
Ganesh Vilas ShelkeUniversity of Gothenburg, Institute of Clinical Sciences, Department of Surgery, Sahlgrenska Cancer Center, Gothenburg, Sweden.
Ashok K ShettyResearch Service, Olin E. Teague Veterans' Medical Center, Temple, TX, USA.
Kiyotaka ShibaCancer Institute of JFCR, Tokyo, Japan.
Pia R-M SiljanderUniversity of Helsinki, EV Core Facility, Helsinki, Finland.
Andreia M SilvaINEB - Instituto de Engenharia Biomédica, Porto, Portugal.
Agata SkowronekMaria Sklodowska-Curie Institute - Oncology Center, Gliwice Branch, Gliwice, Poland.
Orman L SnyderKansas State University, College of Veterinary Medicine, Manhattan, KS, USA.
Rodrigo Pedro SoaresRené Rachou Institute/FIOCRUZ, Belo Horizonte, Brazil.
Barbara W SódarSemmelweis University, Department of Genetics, Cell- and Immunobiology, Budapest, Hungary.
Carolina SoekmadjiQIMR Berghofer Medical Research Institute, Herston, Australia.
Javier SotilloJames Cook University, Australian Institute of Tropical Health and Medicine, Centre for Biodiscovery and Molecular Development of Therapeutics, Cairns, Australia.
Philip D StahlWashington University, Saint Louis, MO, USA.
Willem StoorvogelUtrecht University, Faculty of Veterinary Medicine, Department of Biochemistry and Cell Biology, Utrecht, The Netherlands.
Shannon L StottHarvard Medical School, Department of Medicine, Boston, MA, USA.
Erwin F StrasserFAU Erlangen-Nuremberg, Transfusion and Haemostaseology Department, Erlangen, Germany.
Simon SwiftUniversity of Auckland, Department of Molecular Medicine and Pathology, Auckland, New Zealand.
Hidetoshi TaharaHiroshima University, Institute of Biomedical & Health Sciences, Department of Cellular and Molecular Biology, Hiroshima, Japan.
Muneesh TewariUniversity of Michigan, Biointerfaces Institute, Ann Arbor, MI, USA.
Kate TimmsUniversity of Manchester, Manchester, UK.
Swasti TiwariGeorgetown University, Department of Medicine, Washington, DC, USA.
Rochelle TixeiraLa Trobe University, La Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, Bundoora, Australia.
Mercedes TkachInstitut Curie, INSERM U932, PSL Research University, Paris, France.
Wei Seong TohNational University of Singapore, Faculty of Dentistry, Singapore.
Richard TomasiniINSERM U1068, Aix Marseille University, CNRS UMR7258, Marseille, France.
Ana Claudia TorrecilhasUNIFESP, Departamento de Ciências Farmacêuticas, Diadema, Brazil.
Juan Pablo TosarInstitut Pasteur de Montevideo, Functional Genomics Unit, Montevideo, Uruguay.
Vasilis ToxavidisBeth Israel Deaconess Medical Center, Boston, MA, USA.
Lorena UrbanelliUniversity of Perugia, Department of Chemistry, Biology and Biotechnology, Perugia, Italy.
Pieter VaderUniversity Medical Center Utrecht, Laboratory for Clinical Chemistry & Hematology, Utrecht, The Netherlands.
Bas Wm van BalkomUniversity Medical Center Utrecht, Department of Nephrology and Hypertension, Utrecht, The Netherlands.
Susanne G van der GreinUtrecht University, Faculty of Veterinary Medicine, Department of Biochemistry and Cell Biology, Utrecht, The Netherlands.
Jan Van DeunCancer Research Institute Ghent, Ghent, Belgium.
Martijn Jc van HerwijnenUtrecht University, Faculty of Veterinary Medicine, Department of Biochemistry and Cell Biology, Utrecht, The Netherlands.
Kendall Van Keuren-JensenTGen, Neurogenomics Division, Phoenix, AZ, USA.
Guillaume van NielCenter for Psychiatry and Neuroscience, INSERM U894, Paris, France.
Martin E van RoyenDepartment of Pathology, Erasmus MC, Erasmus Optical Imaging Centre, Rotterdam, The Netherlands.
Andre J van WijnenMayo Clinic, Department of Orthopedic Surgery, Rochester, MN, USA.
M Helena VasconcelosIPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal.
Ivan J VechettiUniversity of Kentucky, College of Medicine, Department of Physiology, Lexington, KY, USA.
Tiago D VeitUniversidade Federal do Rio Grande do Sul, Instituto de Ciências Básicas da Saúde, Departamento de Microbiologia, Imunologia e Parasitologia, Porto Alegre, Brazil.
Laura J VellaThe Florey Institute of Neuroscience and Mental Health, Melbourne, Australia.
Émilie VelotUMR 7365 CNRS-Université de Lorraine, Vandœuvre-lès-Nancy, France.
Frederik J VerweijCenter for Psychiatry and Neuroscience, INSERM U894, Paris, France.
Beate VestadOslo University Hospital Rikshospitalet, Research Institute of Internal Medicine, Oslo, Norway.
Jose L ViñasKidney Research Centre, Ottawa, Canada.
Tamás VisnovitzSemmelweis University, Department of Genetics, Cell- and Immunobiology, Budapest, Hungary.
Krisztina V VukmanSemmelweis University, Department of Genetics, Cell- and Immunobiology, Budapest, Hungary.
Jessica WahlgrenUniversity of Gothenburg, The Sahlgrenska Academy, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Mölndal, Sweden.
Dionysios C WatsonCase Western Reserve University, Department of Medicine, Cleveland, OH, USA.
Marca Hm WaubenUtrecht University, Faculty of Veterinary Medicine, Department of Biochemistry and Cell Biology, Utrecht, The Netherlands.
Alissa WeaverVanderbilt University School of Medicine, Department of Cell and Developmental Biology, Nashville, TN, USA.
Jason P WebberCardiff University, School of Medicine, Cardiff, UK.
Viktoria WeberDanube University Krems, Department for Biomedical Research and Christian Doppler Laboratory for Innovative Therapy Approaches in Sepsis, Krems an der Donau, Austria.
Ann M WehmanUniversity of Würzburg, Rudolf Virchow Center, Würzburg, Germany.
Daniel J WeissThe University of Vermont Medical Center, Department of Medicine, Burlington, VT, USA.
Joshua A WelshNational Institutes of Health, National Cancer Institute, Center for Cancer Research, Bethesda, MD, USA.
Sebastian WendtUniversity Hospital RWTH Aachen, Department of Thoracic and Cardiovascular Surgery, Aachen, Germany.
Asa M WheelockKarolinska Institute, Department of Medicine and Center for Molecular Medicine, Respiratory Medicine Unit, Stockholm, Sweden.
Zoltán WienerSemmelweis University, Department of Genetics, Cell- and Immunobiology, Budapest, Hungary.
Leonie WitteUniversity Medical Center Göttingen, Developmental Biochemistry, Göttingen, Germany.
Joy WolframChinese Academy of Sciences, Wenzhou Institute of Biomaterials and Engineering, Wenzhou, China.
Angeliki XagorariGeorge Papanicolaou Hospital, Public Cord Blood Bank, Department of Haematology - BMT Unit, Thessaloniki, Greece.
Patricia XanderUniversidade Federal de São Paulo Campus Diadema, Departamento de Ciências Farmacêuticas, Laboratório de Imunologia Celular e Bioquímica de Fungos e Protozoários, São Paulo, Brazil.
Jing XuBC Cancer, Canada's Michael Smith Genome Sciences Centre, Vancouver, Canada.
Xiaomei YanXiamen University, Department of Chemical Biology, Xiamen, China.
María Yáñez-MóCentro de Biología Molecular Severo Ochoa, Instituto de Investigación Sanitaria la Princesa (IIS-IP), Madrid, Spain.
Hang YinTsinghua University, School of Pharmaceutical Sciences, Beijing, China.
Yuana YuanaTechnical University Eindhoven, Faculty Biomedical Technology, Eindhoven, The Netherlands.
Valentina ZappulliUniversity of Padova, Department of Comparative Biomedicine and Food Science, Padova, Italy.
Jana ZarubovaInstitute of Physiology CAS, Department of Biomaterials and Tissue Engineering, BIOCEV, Vestec, Czech Republic.
Vytautas ŽėkasVilnius University, Institute of Biomedical Sciences, Department of Physiology, Biochemistry, Microbiology and Laboratory Medicine, Vilnius, Lithuania.
Jian-Ye ZhangGuangzhou Medical University, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Key Laboratory of Molecular Target & Clinical Pharmacology, Guangzhou, China.
Zezhou ZhaoThe Johns Hopkins University School of Medicine, Department of Molecular and Comparative Pathobiology, Baltimore, MD, USA.
Lei ZhengNanfang Hospital, Southern Medical University, Department of Clinical Laboratory Medicine, Guangzhou, China.
Alexander R ZheutlinUniversity of Michigan Medical School, Ann Arbor, MI, USA.
Antje M ZicklerKarolinska Institute, Clinical Research Center, Unit for Molecular Cell and Gene Therapy Science, Stockholm, Sweden.
Pascale ZimmermannAix-Marseille Université, Institut Paoli-Calmettes, INSERM U1068, CNRS UMR7258, Centre de Recherche en Cancérologie de Marseille, Marseille, France.
Angela M ZivkovicUniversity of California, Davis, Department of Nutrition, Davis, CA, USA.
Davide ZoccoExosomics Siena SpA, Siena, Italy.
Ewa K Zuba-SurmaJagiellonian University, Faculty of Biochemistry, Biophysics and Biotechnology, Department of Cell Biology, Kraków, Poland.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
UC Davis Clinical and Translational Science CenterUL1TR001860 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KENYON, NICHOLAS J., LYLES, COURTNEY REES · 2016 to 2025
$47.3M
The role of microvesicles in giloma virotherapyP01CA069246 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI BREAKEFIELD, XANDRA OWENS, CHIOCCA, E. ANTONIO · 1996 to 2021
$30.9M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Cellular Interactions with ThrombospondinZIASC009172 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI ROBERTS, DAVID D · 2009 to 2024
$17.9M
Role of Runx2 in prostate tumorigenesis and metastasisP01CA140043 · NCI · WISTAR INSTITUTE · PI ALTIERI, DARIO C · 2010 to 2021
$12.2M
Institutional Career Development Core (KL2)KL2TR001859 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HOLMES, JAMES F. · 2016 to 2025
$10.1M
Training Program In Basic & Translational Cardiovascular ScienceT32HL086350 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Martin Cadeiras, David A. Liem · 2008 to 2026
$7.1M
Training Veterinarians for Careers in Biomedical ResearchT32OD011089 · OD · JOHNS HOPKINS UNIVERSITY · PI JOSEPH L MANKOWSKI · 2012 to 2026
$6.7M
Trafficking of eRNAs in K-Ras Mutant Colon CancerU19CA179514 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COFFEY, ROBERT J. · 2013 to 2017
$5.3M
Liquid Biopsy for treatment stratification of IDH1.R132H and EGFRvIII mutant gliomasU01CA230697 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CARTER, BOB S, SKOG, JOHAN · 2018 to 2022
$4.0M
Pathobiology of Liver InjuryR01DK111378 · NIDDK · MAYO CLINIC ROCHESTER · PI MALHI, HARMEET · 2016 to 2025
$3.9M
Biotechnology and Biological Sciences Research Council BB/E002080/1Cancer Research UK 19076Medical Research Council MR/R023166/1NCATS NIH HHS KL2 TR001859NCATS NIH HHS UL1 TR001860NCI NIH HHS P01 CA069246NCI NIH HHS P01 CA140043NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA193473NCI NIH HHS R01 CA204621NCI NIH HHS R01 CA218526NCI NIH HHS R01 CA224769NCI NIH HHS U01 CA230697NCI NIH HHS U19 CA179514NHLBI NIH HHS T32 HL086350NHLBI NIH HHS U01 HL126499NIA NIH HHS R56 AG057430NIA NIH HHS T32 AG052375NIDA NIH HHS R01 DA040385NIDA NIH HHS R01 DA047807NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK111378NIGMS NIH HHS R01 GM117916NIH HHS T32 OD011089NIMH NIH HHS R01 MH113645NIMH NIH HHS R21 MH118164NIMH NIH HHS R33 MH118164
6 · The paper itself

Abstract

The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles ("MISEV") guidelines for the field in 2014. We now update these "MISEV2014" guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.

Indexed as

ectosomesexosomesextracellular vesiclesguidelinesmicroparticlesmicrovesiclesminimal information requirementsreproducibilityrigorstandardization

Identifiers

PMID30637094
PMCPMC6322352

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