ArticleThe Pan African medical journal2018
Factors associated with tuberculosis treatment failure in the Central East Health region of Burkina Faso.
Article in The Pan African medical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Tuberculosis disease characteristics associated with mortality, severe morbidity and unsuccessful treatment in people living with HIV treated for tuberculosis - a secondary analysis of the ANRS 12300 Reflate TB2 trial.BMC infectious diseases · 2025Trial
- Pharmacodynamic biomarkers for quantifying the mycobacterial effect of high doses of rifampin in patients with rifampin-susceptible pulmonary tuberculosis.International journal of mycobacteriologyTrial
- Tuberculosis and HIV Coinfection Admissions and Outcome in Children at a Nigerian Tertiary Hospital.Annals of African medicine · 2026Article
- A machine learning approach to explore individual risk factors for tuberculosis treatment non-adherence in Mukono district.PLOS global public health · 2023Article
- Smear grading at initial treatment association with treatment outcomes among new smear positive pulmonary tuberculosis patients: A retrospective study.Journal of preventive medicine and hygiene · 2022Article
- An Investigation of Risk Factors Associated with Tuberculosis Transmission in South Africa Using Logistic Regression Model.Infectious disease reports · 2022Article
- Treatment outcome of tuberculosis patient of Samtse General Hospital, Bhutan.Nepal journal of epidemiology · 2020Article
- Article
- Pharmacodynamic Functions of Synthetic Derivatives for Treatment of Methicillin-ResistantFrontiers in microbiology · 2020Article
- Prevalence of Tuberculosis by Automated GeneXpert Rifampicin Assay and Associated Risk Factors Among Presumptive Pulmonary Tuberculosis Patients at Ataye District Hospital, North East Ethiopia.Infection and drug resistance · 2020Article
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6 authors.
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Abstract
introductionTuberculosis treatment failure results in increased risk of morbidity, drug resistance, transmission and mortality. There are few data about tuberculosis treatment outcomes in Burkina Faso. The current study investigated the factors associated with tuberculosis treatment failure in the central east health region of Burkina Faso.
methodsWe conducted a case-control study. All cases of pulmonary tuberculosis failing first-line treatment matched to those who were cured (controls) in the Central Eastern Region were sampled from January 2010 to December 2014. Predictors of treatment failure were determined using multiple conditional logistic regression.
resultsA total of 381 patients with positive microscopic pulmonary tuberculosis were included. Of these 76 cases failed first-line treatment while 305 controls were cured. Weight loss between diagnosis and first sputum-smear examination was significantly associated with the tuberculosis treatment failure [aOR: 2.5, 95% CI: 1.3-4.7]. In addition, the delay from between treatment initiation to first sputum-smear examination, and high bacillary load at the first sputum-smear examination were significantly associated with treatment failure (p<0.001).
conclusionStrengthening the relationship between health care services and local communities to improve the follow-up of tuberculosis patients, and improving adherence to tuberculosis treatment among tuberculosis patients with weight loss between treatment initiation and 2-month sputum-smear examination could be useful to reduce the risk of unsuccessful outcome.
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