ArticleForensic toxicology2019
A GC-MS method for the determination of furanylfentanyl and ocfentanil in whole blood with full validation.
Article in Forensic toxicology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 28 citations in OpenAlex.
- Development and Validation of a Gas Chromatography-Mass Spectrometry Method for the Determination of Fentanyl and Butyryl Fentanyl in Oral Fluid.Analytical science advances · 2025Article
- Metabolomics Research in Periodontal Disease by Mass Spectrometry.Molecules (Basel, Switzerland) · 2022Review
- Electroanalysis of Fentanyl and Its New Analogs: A Review.Biosensors · 2022Review
- Synthetic opioids: a review and clinical update.Therapeutic advances in psychopharmacology · 2022Review
- Development and evaluation of a synthetic opioid targeted gas chromatography mass spectrometry (GC-MS) method.Journal of forensic sciences · 2021Article
- Application of the fentanyl analog screening kit toward the identification of emerging synthetic opioids in human plasma and urine by LC-QTOF.Toxicology letters · 2020Article
- Interpol review of toxicology 2016-2019.Forensic science international. Synergy · 2020Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeFentanyl analogues are popular in recent years among drug addicts and have been related to many overdoses and deaths worldwide. Furanylfentanyl, ocfentanil, acetylfentanyl and butyrfentanyl are among the most common of these drugs. Methods for the determination of furanylfentanyl and ocfentanil by gas chromatography-mass spectrometry (GC-MS) in biological samples do not exist, and therefore, their development would be extremely useful for routine toxicological analysis.
methodsA GC-MS method was developed and fully validated for the determination of furanylfentanyl and ocfentanil in whole blood. This method was also suitable for the determination of acetylfentanyl and butyrfentanyl. The method included solid-phase extraction after protein precipitation using acetonitrile, and it was applied during the toxicological investigation of forensic cases. Methadone-
resultsThe limit of detection and limit of quantification values were 0.30 and 1.0 ng/mL for furanylfentanyl and ocfentanil and 0.15 and 0.50 ng/mL for acetylfentanyl and butyrfentanyl, respectively. The calibration curves were linear (
conclusionsThe developed method is the first one in the literature for the detection of furanylfentanyl and ocfentanil in biological fluids by GC-MS, and it provides very high sensitivity comparable to that by liquid chromatography-tandem mass spectrometry.
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