Evidence map›Paper›PMID 30636842›Full record

ArticleTechniques in orthopaedics (Rockville, Md.)2018

Reconstructive Science in Orthopedic Oncology.

Zachary D C Burke, Gideon W Blumstein, Stephen D Zoller, Howard Y Park, Nicholas M Bernthal

Abstract read
In one paragraph

Article in Techniques in orthopaedics (Rockville, Md.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zachary D C BurkeDepartment of Orthopaedic Surgery, David Geffen School of Medicine at UCLA.
Gideon W BlumsteinDepartment of Orthopaedic Surgery, David Geffen School of Medicine at UCLA.
Stephen D ZollerDepartment of Orthopaedic Surgery, David Geffen School of Medicine at UCLA.
Howard Y ParkDepartment of Orthopaedic Surgery, David Geffen School of Medicine at UCLA.
Nicholas M BernthalUCLA / ORTHOPAEDIC INSTITUTE FOR CHILDREN DEPARTMENT OF ORTHOPAEDIC SURGERY, DAVID GEFFEN SCHOOL OF MEDICINE AT UCLA 1250 16TH STREET, SUITE 3142, SANTA MONICA, CA 90404.

Funding

Regenerative Musculoskeletal Medicine Training ProgramT32AR059033 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI John S Adams, Nicholas M. Bernthal · 2011 to 2026
$4.8M
Modifying and Delivering Antimicrobials to Prevent Orthopaedic Implant InfectionsK08AR069112 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BERNTHAL, NICHOLAS M. · 2016 to 2019
$704k
NIAMS NIH HHS K08 AR069112NIAMS NIH HHS T32 AR059033
6 · The paper itself

Abstract

Limb salvage is widely practiced as standard of care in most cases of extremity bone sarcoma. Allograft and endoprosthesis reconstructions are the most widely utilized modalities for the reconstruction of large segment defects, however complication rates remain high. Aseptic loosening and infection remain the most common modes of failure. Implant integration, soft-tissue function, and infection prevention are crucial for implant longevity and function. Macro and micro alterations in implant design are reviewed in this manuscript. Tissue engineering principles using nanoparticles, cell-based, and biological augments have been utilized to develop implant coatings that improve osseointegration and decrease infection. Similar techniques have been used to improve the interaction between soft tissues and implants. Tissue engineered constructs (TEC) used in combination with, or in place of, traditional reconstructive techniques may represent the next major advancement in orthopaedic oncology reconstructive science, although preclinical results have yet to achieve durable translation to the bedside.

Indexed as

biofilmimplant coatingsOsseointegrationperiprosthetic infectionsoft tissue attachments

Identifiers

PMID30636842
PMCPMC6326169

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.