ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2019
Altered frontostriatal white matter microstructure is associated with familial alcoholism and future binge drinking in adolescence.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Adolescent Alcohol and Stress Exposure Rewires Key Cortical Neurocircuitry.Frontiers in neuroscience · 2022Pooled it
- Substance use involvement moderates the effect of cortisol response on white-matter microstructure longitudinally.Dialogues in clinical neuroscience · 2026Article
- Family History of Substance Use and Stressful Life Events Impact Adolescent Maturation of Cerebral White Matter.Addiction biology · 2025Article
- Adolescent Alcohol Exposure Dysregulates Developing Cortical GABA Circuits.Advances in experimental medicine and biology · 2025Review
- A longitudinal study of the relationship between alcohol-related blackouts and attenuated structural brain development.Developmental cognitive neuroscience · 2024Article
- Unveiling Promising Neuroimaging Biomarkers for Schizophrenia Through Clinical and Genetic Perspectives.Neuroscience bulletin · 2024Review
- Neuroimaging in Adolescents: Post-Traumatic Stress Disorder and Risk for Substance Use Disorders.Genes · 2023Review
- Heightened adolescent emotional reactivity in the brain is associated with lower future distress tolerance and higher depressive symptoms.Psychiatry research. Neuroimaging · 2023Article
- Adolescent Substance Use Is Associated With Altered Brain Response During Processing of Negative Emotional Stimuli.Journal of studies on alcohol and drugs · 2023Article
- Article
- Alcohol and the Brain.Nutrients · 2021Review
- Lifetime Alcohol Use Influences the Association Between Future-Oriented Thought and White Matter Microstructure in Adolescents.Alcohol and alcoholism (Oxford, Oxfordshire) · 2021Article
- Promising vulnerability markers of substance use and misuse: A review of human neurobehavioral studies.Neuropharmacology · 2021Review
- Functional Connectivity Predicts Individual Development of Inhibitory Control during Adolescence.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Sex hormones partially explain the sex-dependent effect of lifetime alcohol use on adolescent white matter microstructure.Psychiatry research. Neuroimaging · 2021Article
- Risks versus consequences of adolescent and young adult substance use: A focus on executive control.Current addiction reports · 2020Article
- Effect of alcohol use on the adolescent brain and behavior.Pharmacology, biochemistry, and behavior · 2020Review
- Associations between nucleus accumbens structural connectivity, brain function, and initiation of binge drinking.Addiction biology · 2020Article
- Sex Differences in the Neurobiology of Alcohol Use Disorder.Alcohol research : current reviews · 2020Review
- Neurophysiological Correlates and Differential Drug Response in Subjects With a Family History of an Alcohol Use Disorder.Chronic stress (Thousand Oaks, Calif.)Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Adolescence is a time of significant neurobiological development, including changes in white matter microstructure. Familial alcoholism and adolescent binge-drinking have both been associated with altered white matter microstructure; however, the temporal nature of these effects, and their interaction, is unclear. Using diffusion-weighted imaging and voxel-wise multilevel modeling, the effects of familial alcoholism and future binge-drinking on white matter microstructural development were assessed in 45 adolescents, who went on to binge-drink (but were alcohol-naive at baseline), and 68 adolescents, who remained largely alcohol-naive, all with varying degrees of familial alcoholism. Both future binge-drinking and familial alcoholism were associated with altered frontostriatal white matter microstructure early in adolescence, prior to alcohol use. While several binge-drinking-related effects persisted throughout adolescence (in the posterior limb of the internal capsule, superior corona radiata, and cerebellar peduncles), the association between familial alcoholism and altered white matter microstructure dissipated across adolescence in all regions. There were no white matter regions identified where future binge-drinking or familial alcoholism were significantly associated with emergent or exacerbated alterations in white matter microstructure. Altogether, these findings suggest that alterations in frontostiatal white matter microstructure, some of which are associated with familial alcoholism, may be used to predict which adolescents are more likely to go on and engage in alcohol use. Meanwhile, a reduction in family history-related associations with altered white matter microstructure by late-adolescence is encouraging for future prevention work targeted at at-risk youth.
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