Evidence map›Paper›PMID 30636420›Full record

ArticleJournal of natural products2019

Chemical and Metagenomic Studies of the Lethal Black Band Disease of Corals Reveal Two Broadly Distributed, Redox-Sensitive Mixed Polyketide/Peptide Macrocycles.

Sarath P Gunasekera, Julie L Meyer, Yousong Ding, Khalil A Abboud, Danmeng Luo, Justin E Campbell, Alexander Angerhofer, Justin L Goodsell, Laurie J Raymundo, Junyang Liu and 4 more

Abstract read
In one paragraph

Article in Journal of natural products, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Total Synthesis ofOrganic letters · 2022
    Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sarath P GunasekeraSmithsonian Marine Station , Ft. Pierce , Florida 34949 , United States.
Julie L MeyerSoil and Water Sciences Department , University of Florida-Institute of Food and Agricultural Sciences , Gainesville , Florida 32611 , United States.
Yousong DingDepartment of Medicinal Chemistry and Center for Natural Products, Drug Discovery and Development , University of Florida , Gainesville , Florida 32610 , United States.ORCID 0000-0001-8610-0659
Khalil A AbboudDepartment of Chemistry , University of Florida , Gainesville , Florida 32611 , United States.
Danmeng LuoDepartment of Medicinal Chemistry and Center for Natural Products, Drug Discovery and Development , University of Florida , Gainesville , Florida 32610 , United States.
Justin E CampbellSmithsonian Marine Station , Ft. Pierce , Florida 34949 , United States.
Alexander AngerhoferDepartment of Chemistry , University of Florida , Gainesville , Florida 32611 , United States.ORCID 0000-0002-8580-6024
Justin L GoodsellDepartment of Chemistry , University of Florida , Gainesville , Florida 32611 , United States.
Laurie J RaymundoUniversity of Guam Marine Laboratory , Mangilao , GU 96923 , United States.
Junyang LiuState Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology , Peking University Shenzhen Graduate School , Xili, Nanshan District, Shenzhen , 518055 , People's Republic of China.
Tao YeState Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology , Peking University Shenzhen Graduate School , Xili, Nanshan District, Shenzhen , 518055 , People's Republic of China.ORCID 0000-0002-2780-9761
Hendrik LueschDepartment of Medicinal Chemistry and Center for Natural Products, Drug Discovery and Development , University of Florida , Gainesville , Florida 32610 , United States.ORCID 0000-0002-4091-7492
Max TeplitskiSmithsonian Marine Station , Ft. Pierce , Florida 34949 , United States.
Valerie J PaulSmithsonian Marine Station , Ft. Pierce , Florida 34949 , United States.ORCID 0000-0002-4691-1569

Funding

Novel Targeted Anticancer Agents from Marine CyanobacteriaR01CA172310 · NCI · UNIVERSITY OF FLORIDA · PI HENDRIK LUESCH · 2013 to 2026
$5.8M
NIH Equipment Supplement to R35GM128742R35GM128742 · NIGMS · UNIVERSITY OF FLORIDA · PI Yousong Ding · 2018 to 2026
$3.4M
NCI NIH HHS R01 CA172310NIGMS NIH HHS R35 GM128742
6 · The paper itself

Abstract

Black band disease (BBD), a lethal, polymicrobial disease consortium dominated by the cyanobacterium Roseofilum reptotaenium, kills many species of corals worldwide. To uncover chemical signals or cytotoxins that could be important in proliferation of Roseofilum and the BBD layer, we examined the secondary metabolites present in geographically diverse collections of BBD from Caribbean and Pacific coral reefs. Looekeyolide A (1), a 20-membered macrocyclic compound formed by a 16-carbon polyketide chain, 2-deamino-2-hydroxymethionine, and d-leucine, and its autoxidation product looekeyolide B (2) were extracted as major compounds (∼1 mg g

Indexed as

AnimalsAnthozoaCoral ReefsCyanobacteriaMacrocyclic CompoundsMetagenomicsOxidation-ReductionPolyketidesMacrocyclic CompoundsPolyketides

Identifiers

PMID30636420
PMCPMC6350197

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.