ArticleJournal of the American Chemical Society2019
11-Step Total Synthesis of Teleocidins B-1-B-4.
Article in Journal of the American Chemical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Electrochemically Enabled Total Syntheses of Natural Products.ChemElectroChem · 2023Article
- Transition metal-catalyzed remote C─H borylation: An emerging synthetic tool.Science advances · 2023Review
- Indolactam Dipeptides as Nanomolar Gli Inhibitors.ACS medicinal chemistry letters · 2022Article
- Electrochemically Mediated Oxidation of Sensitive Propargylic Benzylic Alcohols.Organic letters · 2022Article
- Enzymatic reactions in teleocidin B biosynthesis.Journal of natural medicines · 2021Review
- Ideality in Context: Motivations for Total Synthesis.Accounts of chemical research · 2021Article
- C4-arylation and domino C4-arylation/3,2-carbonyl migration of indoles by tuning Pd catalytic modes: Pd(i)-Pd(ii) catalysisChemical science · 2021Article
- Stereoselective Remote Functionalization via Palladium-Catalyzed Redox-Relay Heck Methodologies.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Review
- Staurosporine Analogs Via C-H Borylation.ACS medicinal chemistry letters · 2020Article
- In Praise of Basic Research as a Vehicle to Practical Applications: Palladium-Catalyzed Coupling to Form Carbon-Nitrogen Bonds.Israel journal of chemistry · 2020Article
- A Survival Guide for the "Electro-curious".Accounts of chemical research · 2020Review
- Oxodealkenylative Cleavage of Alkene C(spAngewandte Chemie (International ed. in English) · 2020Article
- Molecular basis for the P450-catalyzed C-N bond formation in indolactam biosynthesis.Nature chemical biology · 2019Article
- Acyl-Directed ortho-Borylation of Anilines and C7 Borylation of Indoles using just BBrAngewandte Chemie (International ed. in English) · 2019Article
- Synthesis of bicyclic ethers by a palladium-catalyzed oxidative cyclization-redox relay-π-allyl-Pd cyclization cascade reaction.Chemical communications (Cambridge, England) · 2019Article
- Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications.Journal of the American Chemical Society · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
A unified and modular approach to the teleocidin B family of natural products is presented that proceeds in 11 steps and features an array of interesting strategies and methods. Indolactam V, the known biosynthetic precursor to this family, was accessed through electrochemical amination, Cu-mediated aziridine opening, and a remarkable base-induced macrolactamization. Guided by a desire to minimize concession steps, the tactical combination of C-H borylation and a Sigman-Heck transform enabled the convergent, stereocontrolled synthesis of the teleocidins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.