Evidence map›Paper›PMID 30636092›Full record

ReviewJournal of viral hepatitis2019

Clinical features and determinants of chronicity in hepatitis E virus infection.

Shivakumar Narayanan, Ameer Abutaleb, Kenneth E Sherman, Shyam Kottilil

Abstract readReview
In one paragraph

Review in Journal of viral hepatitis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Structural aspects of hepatitis E virus.Archives of virology · 2022
    Review
  5. Article
  6. Article
  7. Nosocomial transmission of hepatitis E virus and development of chronic infection: The wider impact of COVID-19.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2022
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. The CD8Microbiology and molecular biology reviews : MMBR · 2021
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shivakumar NarayananDivision of Clinical Care and Research, Institute of Human Virology, University of Maryland, Baltimore, Maryland.
Ameer AbutalebDivision of Clinical Care and Research, Institute of Human Virology, University of Maryland, Baltimore, Maryland.
Kenneth E ShermanDivision of Digestive Diseases, University of Cincinnati, Cincinnati, Ohio.
Shyam KottililDivision of Clinical Care and Research, Institute of Human Virology, University of Maryland, Baltimore, Maryland.ORCID https://orcid.org/0000-0001-7471-0812

Funding

Research Training in Gastroenterology and HepatologyT32DK067872 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI RAUFMAN, JEAN-PIERRE · 2005 to 2024
$7.2M
Mentorship in Liver DiseaseK24DK070528 · NIDDK · UNIVERSITY OF CINCINNATI · PI SHERMAN, KENNETH E · 2005 to 2014
$1.4M
Hepatitis E in HIV-Infected PatientsR01DK108362 · NIDDK · UNIVERSITY OF CINCINNATI · PI SHERMAN, KENNETH E · 2015 to 2019
$1.4M
KES 1RO1KD108363NIDDK NIH HHS K24 DK070528NIDDK NIH HHS R01 DK108362NIDDK NIH HHS T32 DK067872NIH HHS R01DK108362
6 · The paper itself

Abstract

Hepatitis E virus (HEV) has traditionally been associated with an acute, self-limiting hepatitis and is not known to have any chronic sequelae. HEV genotypes 1 and 2, which are human pathogens, have been associated with this self-limiting presentation, in both sporadic and epidemic settings. HEV genotype 3, which is zoonotically transmitted, is increasingly being reported as a cause of chronic infection in immunocompromised patients. These include patients with solid organ transplants, patients receiving chemotherapy for haematologic malignancies and patients infected with HIV. Chronic infection is associated with rapidly progressing liver disease and extrahepatic manifestations including neurologic disorders. We review the clinical manifestations of chronic HEV infection and discuss factors determining persistence and chronicity of HEV.

Indexed as

Antiviral AgentsCytokinesGenotypeHepatitis, ChronicHepatitis EHepatitis E virusHumansImmunocompromised HostAntiviral AgentsCytokineschronic HEVgenotype 3hepatitis E virus

Identifiers

PMID30636092
PMCPMC6437685

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.