Evidence map›Paper›PMID 30636005›Full record

ArticleAllergy2019

AllergoOncology: Microbiota in allergy and cancer-A European Academy for Allergy and Clinical Immunology position paper.

Eva Untersmayr, Heather J Bax, Christoph Bergmann, Rodolfo Bianchini, Wendy Cozen, Hannah J Gould, Karin Hartmann, Debra H Josephs, Francesca Levi-Schaffer, Manuel L Penichet and 8 more

Open access · hybridAbstract readConsensus Statement
In one paragraph

Article in Allergy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. AllergoOncology in Review: Harnessing Allergy in the Field of Oncology to Improve Patient Outcomes.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 14 institutions in 11 countries.

Eva UntersmayrInstitute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University Vienna, Vienna, Austria.ORCID 0000-0002-1963-499X
Heather J BaxSt. John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, Guy's Hospital, London, UK.
Christoph BergmannENT Research Institute for Clinical Studies, Essen, Germany.
Rodolfo BianchiniComparative Medicine, The Interuniversity Messerli Research Institute, University of Veterinary Medicine Vienna, Medical University Vienna, University Vienna, Vienna, Austria.ORCID 0000-0003-0351-6937
Wendy CozenCenter for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.ORCID 0000-0003-3415-8247
Hannah J GouldRandall Centre for Cell and Molecular Biophysics, School of Basic & Medical Biosciences, King's College London, New Hunt's House, London, UK.
Karin HartmannDepartment of Dermatology, University of Luebeck, Luebeck, Germany.
Debra H JosephsSt. John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, Guy's Hospital, London, UK.
Francesca Levi-SchafferPharmacology and Experimental Therapeutics Unit, School of Pharmacy, Faculty of Medicine, The Institute for Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel.
Manuel L PenichetDivision of Surgical Oncology, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Liam O'MahonyDepartments of Medicine and Microbiology, APC Microbiome Ireland, National University of Ireland, Cork, Ireland.ORCID 0000-0003-4705-3583
Aurelie PoliDepartment of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Frank A RedegeldDivision of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
Franziska Roth-WalterComparative Medicine, The Interuniversity Messerli Research Institute, University of Veterinary Medicine Vienna, Medical University Vienna, University Vienna, Vienna, Austria.ORCID 0000-0001-5005-9228
Michelle C TurnerBarcelona Institute for Global Health (ISGlobal), Barcelona, Spain.
Luca VangelistaDepartment of Biomedical Sciences, Nazarbayev University School of Medicine, Astana, Kazakhstan.ORCID 0000-0003-0764-5031
Sophia N KaragiannisSt. John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, Guy's Hospital, London, UK.ORCID 0000-0002-4100-7810
Erika Jensen-JarolimInstitute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University Vienna, Vienna, Austria.ORCID 0000-0003-4019-5765
Guy's Hospital · GBUniversity of Veterinary Medicine Vienna · ATEssen University Hospital · DEHebrew University of Jerusalem · ILKing's College London · GBLuxembourg Institute of Health · LUMedical University of Vienna · ATNational University of Ireland · IENazarbayev University · KZUniversity of California, Los Angeles · USUniversity of Lübeck · DEUniversity of Ottawa · CAUniversity of Southern California · USUtrecht University · NL

Funding

A Novel Strategy Targeting TfR1 for the Prevention/Treatment of AIDS-related NHLR01CA196266 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARTINEZ-MAZA, OTONIEL, PENICHET, MANUEL L · 2016 to 2020
$3.4M
A Novel Anti-HER2/neu IgE for Breast Cancer TherapyR01CA181115 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PENICHET, MANUEL L · 2014 to 2018
$2.5M
Comparison of the Fecal Microbiome in Identical Twins Discordant for Colon PolypsR03CA173842 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI COZEN, WENDY · 2014 to 2015
$165k
Breast Cancer Now C10355/A15587Cancer Research UK C30122/A11527Cancer Research UK C30122/A15774Medical Research Council G0200486Medical Research Council G0501494Medical Research Council G1000758Medical Research Council G1100090Medical Research Council MR/L023091/1NCI NIH HHS R01 CA181115NCI NIH HHS R01 CA196266NCI NIH HHS R03 CA173842
6 · The paper itself

Abstract

The microbiota can play important roles in the development of human immunity and the establishment of immune homeostasis. Lifestyle factors including diet, hygiene, and exposure to viruses or bacteria, and medical interventions with antibiotics or anti-ulcer medications, regulate phylogenetic variability and the quality of cross talk between innate and adaptive immune cells via mucosal and skin epithelia. More recently, microbiota and their composition have been linked to protective effects for health. Imbalance, however, has been linked to immune-related diseases such as allergy and cancer, characterized by impaired, or exaggerated immune tolerance, respectively. In this AllergoOncology position paper, we focus on the increasing evidence defining the microbiota composition as a key determinant of immunity and immune tolerance, linked to the risk for the development of allergic and malignant diseases. We discuss novel insights into the role of microbiota in disease and patient responses to treatments in cancer and in allergy. These may highlight opportunities to improve patient outcomes with medical interventions supported through a restored microbiome.

Indexed as

AnimalsAsthmaBacteriaChildChild, PreschoolDietEpitheliumFemaleGastrointestinal MicrobiomeHost Microbial InteractionsHumansHygiene HypothesisImmunity, CellularInfantMaleMicronutrientsMicronutrientsallergycancerhygiene hypothesismicrobiotaoncoimmunology

Identifiers

PMID30636005
PMCPMC6563061
OpenAlexW2909762028

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.