ArticleJournal of magnetic resonance imaging : JMRI2019
Analysis of cavopulmonary and cardiac flow characteristics in fontan Patients: Comparison with healthy volunteers.
Article in Journal of magnetic resonance imaging : JMRI, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- 5D Flow MRI Reveals Respiration-Driven Changes in Blood Flow Energetics in Congenital Heart Disease.Magnetic resonance in medicine · 2026Article
- Assessment of hemodynamic disturbances and impaired ventricular filling in asymptomatic fontan patients: A 4D flow CMR study.European journal of radiology open · 2025Article
- Highly accelerated 4D flow MRI with respiratory compensation and cardiac view sharing: a cross-sectional study of flow in the great vessels of pediatric congenital heart disease.Pediatric radiology · 2025Article
- Characteristics of altered biventricular hemodynamics after arterial switch operation for patients with d-transposition of the great arteries with preserved ejection fraction: a four-dimensional (4D) flow cardiovascular magnetic resonance (CMR) study.Quantitative imaging in medicine and surgery · 2024Article
- Impact of pulmonary artery flow distribution on Fontan hemodynamics and flow energetics.Pediatric radiology · 2023Article
- Fully automated intracardiac 4D flow MRI post-processing using deep learning for biventricular segmentation.European radiology · 2022Article
- Intraventricular Flow Simulations in Singular Right Ventricles Reveal Deteriorated Washout and Low Vortex Formation.Cardiovascular engineering and technology · 2022Article
- Performance of Cardiac MRI in Pediatric and Adult Patients with Fontan Circulation.Radiology. Cardiothoracic imaging · 2022Review
- Pilot tone navigation for respiratory and cardiac motion-resolved free-running 5D flow MRI.Magnetic resonance in medicine · 2022Article
- Complications and management of functional single ventricle patients with Fontan circulation: From surgeon's point of view.Frontiers in cardiovascular medicine · 2022Review
- Altered Right Ventricular Filling at Four-dimensional Flow MRI in Young Adults Born Prematurely.Radiology. Cardiothoracic imaging · 2021Article
- Enhancement of cerebrovascular 4D flow MRI velocity fields using machine learning and computational fluid dynamics simulation data.Scientific reports · 2021Article
- Non-uniform mixing of hepatic venous flow and inferior vena cava flow in the Fontan conduit.Journal of the Royal Society, Interface · 2021Article
- Stent interventions for pulmonary artery stenosis improve bi-ventricular flow efficiency in a swine model.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021Article
- 4D flow MRI applications in congenital heart disease.European radiology · 2021Review
- The Influence of Respiration on Blood Flow in the Fontan Circulation: Insights for Imaging-Based Clinical Evaluation of the Total Cavopulmonary Connection.Frontiers in cardiovascular medicine · 2021Review
- 5D Flow MRI: A Fully Self-gated, Free-running Framework for Cardiac and Respiratory Motion-resolved 3D Hemodynamics.Radiology. Cardiothoracic imaging · 2020Article
- Sex Differences in Cardiac Flow Dynamics of Healthy Volunteers.Radiology. Cardiothoracic imaging · 2020Article
- Respiration Dependency of Caval Blood Flow in Patients with Fontan Circulation: Quantification Using 5D Flow MRI.Radiology. Cardiothoracic imaging · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCharacterizing the flow of the Fontan circuit, and correlating flow characteristics with the development of complications, is an important clinical challenge. Past work has analyzed the flow characteristics of Fontan circulation on a component-by-component basis. 4D flow MRI with radial projections allows for large volumetric coverage, and therefore can be used to analyze the flow through many codependent cardiovascular components in a single imaging session. PURPOSE: To describe flow characteristics across the entire Fontan circuit and to compare these with the flow characteristics in healthy volunteers. STUDY TYPE: Prospective. SUBJECTS: Eleven single ventricle patients with a Fontan connection and 15 healthy controls. SEQUENCE: Phase contrast with vastly undersampled isotropic projection reconstruction (PC-VIPR) at a field strength of 3 T. ASSESSMENT: Cavopulmonary and ventricular flow distributions, blood flow kinetic energy, vorticities, efficiency indices, and other flow parameters were analyzed using Ensight and MatLab. STATISTICAL TESTS: The results were compared across Fontan subjects, between respiratory phases, and between Fontan subjects and healthy volunteers using a Student's t-test for unequal sample sizes and linear regression.
resultsCava-specific pulmonary flow distributions of Fontan patients varied significantly between respiratory phases (P < 0.05). Ventricular kinetic energy (KE) was significantly higher in Fontan patients than it was in healthy controls, leading to a lower cardiac efficiency metric in the Fontan group. A significant diastolic KE time-shift was also observed in the Fontan patient group. Peak diastolic KE was significantly higher in the single ventricle of patients with right ventricle morphology than it was in left ventricle morphology patients. DATA
conclusionRadial 4D flow MRI can be used for comprehensive analysis of single ventricle Fontan flow characteristics. LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.