ArticleJournal of magnetic resonance imaging : JMRI2019
Direct comparison between apparent diffusion coefficient and macromolecular proton fraction as quantitative biomarkers of the human fetal brain maturation.
Article in Journal of magnetic resonance imaging : JMRI, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Lymph Node Metastases Prediction in Cervical Cancer Using Time-Dependent Diffusion MRI and Macromolecular Proton Fraction Imaging.Radiology. Imaging cancer · 2026Article
- Multimodal MRI of white matter development and selective motor control in preterm infants.NeuroImage. Clinical · 2026Article
- Global and Regional Sex-Related Differences, Asymmetry, and Peak Age of Brain Myelination in Healthy Adults.Journal of clinical medicine · 2024Article
- Demyelination in Patients with POST-COVID Depression.Journal of clinical medicine · 2024Article
- Sex differences in normal fetal regional brain apparent diffusion coefficient changes assessed byFrontiers in pediatrics · 2024Article
- CLIPPERS: Multiparametric and quantitative MRI features.Radiology case reports · 2023Article
- Assessment of normal myelination in infants and young children using the T1w/T2w mapping technique.Frontiers in neuroscience · 2023Article
- Article
- Role of Demyelination in the Persistence of Neurological and Mental Impairments after COVID-19.International journal of molecular sciences · 2022Review
- Macromolecular Proton Fraction as a Myelin Biomarker: Principles, Validation, and Applications.Frontiers in neuroscience · 2022Review
- Data-Driven Retrospective Correction of BIEEE transactions on medical imaging · 2021Article
- Long-term monitoring of chronic demyelination and remyelination in a rat ischemic stroke model using macromolecular proton fraction mapping.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Global hypomyelination of the brain white and gray matter in schizophrenia: quantitative imaging using macromolecular proton fraction.Translational psychiatry · 2021Article
- Myelin development in cerebral gray and white matter during adolescence and late childhood.NeuroImage · 2021Article
- Imaging of fetal brain tumors.Pediatric radiology · 2020Review
- How to read a fetal magnetic resonance image 101.Pediatric radiology · 2020Review
- Three-dimensional fast single-point macromolecular proton fraction mapping of the human brain at 0.5 Tesla.Quantitative imaging in medicine and surgery · 2020Article
- Multiparametric mapping in post-mortem perinatal MRI: a feasibility study.The British journal of radiology · 2020Article
- Scan-Rescan Repeatability and Impact of BJournal of magnetic resonance imaging : JMRI · 2020Article
- Article
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Authors and funding
4 authors.
Funding
Abstract
backgroundApparent diffusion coefficient (ADC) is known as a quantitative biomarker of prenatal brain maturation. Fast macromolecular proton fraction (MPF) mapping is an emerging method for quantitative assessment of myelination that was recently adapted to fetal MRI. PURPOSE: To compare the capability of ADC and MPF to quantify the normal fetal brain development. STUDY TYPE: Prospective. POPULATION: Forty-two human fetuses in utero (gestational age [GA] = 27.7 ± 6.0, range 20-38 weeks). FIELD STRENGTH/SEQUENCE: 1.5 T; diffusion-weighted single-shot echo-planar spin-echo with five b-values for ADC mapping; spoiled multishot echo-planar gradient-echo with T ASSESSMENT: Two operators measured ADC and MPF in the medulla, pons, cerebellum, thalamus, and frontal, occipital, and temporal cerebral white matter (WM). STATISTICAL TESTS: Mixed repeated-measures analysis of variance (ANOVA) with the factors of pregnancy trimester and brain structure; Pearson correlation coefficient (r); Hotelling-Williams test to compare strengths of correlations.
resultsFrom the 2 DATA
conclusionMPF and ADC demonstrated qualitatively similar but quantitatively different spatiotemporal patterns. MPF appeared more sensitive to changes in the brain structures with prenatal onset of myelination. LEVEL OF EVIDENCE: 2 Technical Efficacy Stage: 2 J. Magn. Reson. Imaging 2019;50:52-61.
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