ArticleBiological trace element research2019
Zinc Deficiency and Arsenic Exposure Can Act Both Independently or Cooperatively to Affect Zinc Status, Oxidative Stress, and Inflammatory Response.
Article in Biological trace element research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Zinc as a Mechanism-Based Strategy for Mitigation of Metals Toxicity.Current environmental health reports · 2025Review
- Protective role of dietary zinc on DNA damage, oxidative stress, and metal toxicity.Frontiers in molecular biosciences · 2025Review
- Pyrimidine Biosynthesis in Branching Morphogenesis Defects Induced by Prenatal Heavy Metal Exposure.American journal of respiratory cell and molecular biology · 2024Article
- Catalytic activity of OGG1 is impaired by Zinc deficiency.DNA repair · 2024Article
- Effectiveness of nanomaterials and their counterparts in improving rice growth and yield under arsenic contamination.Frontiers in plant science · 2024Article
- Zinc supplementation alters tissue distribution of arsenic in Mus musculus.Toxicology and applied pharmacology · 2023Article
- Arsenic binding to human metallothionein-3.Chemical science · 2023Article
- Zinc supplementation prevents mitotic accumulation in human keratinocyte cell lines upon environmentally relevant arsenic exposure.Toxicology and applied pharmacology · 2022Article
- Review
- Zinc Essentiality, Toxicity, and Its Bacterial Bioremediation: A Comprehensive Insight.Frontiers in microbiology · 2022Review
- Age and micronutrient effects on the microbiome in a mouse model of zinc depletion and supplementation.PloS one · 2022Article
- Influence of Dietary Compounds on Arsenic Metabolism and Toxicity. Part I-Animal Model Studies.Toxics · 2021Review
- Influence of Dietary Compounds on Arsenic Metabolism and Toxicity. Part II-Human Studies.Toxics · 2021Review
- Effects of zinc status on age-related T cell dysfunction and chronic inflammation.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2021Article
- Insight into the surface activity of defect structure in α-MnOScientific reports · 2021Article
- Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection.Nutrients · 2021Observational
- Differential response of human T-lymphocytes to arsenic and uranium.Toxicology letters · 2020Article
- Coenzyme Q10, Zinc and MDA levels in verruca vulgarisTurkish journal of medical sciences · 2020Article
- Zinc deficiency alters the susceptibility of pancreatic beta cells (INS-1) to arsenic exposure.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The negative health impact of zinc deficiency overlaps significantly with arsenic exposure, and is associated with increased risk for chronic diseases. Arsenic contamination in the groundwater often co-exists in regions of the world that are prone to zinc deficiency. Notably, low zinc status shares many hallmarks of arsenic exposure, including increased oxidative stress and inflammation. Despite their common targets and frequent co-distribution in the population, little is known regarding the interaction between zinc deficiency and arsenic exposure. In this study, we tested the effect of arsenic exposure at environmentally relevant doses in combination with a physiologically relevant level of zinc deficiency (marginal zinc deficiency) on zinc status, oxidative damage, and inflammation. In cell culture, zinc-deficient THP-1 monocytes co-exposed with arsenic resulted in further reduction in intracellular zinc, as well as further increase in oxidative stress and inflammatory markers. In an animal study, zinc-deficient mice had further decrease in zinc status when co-exposed to arsenic. Zinc deficiency, but not arsenic exposure, resulted in an increase in baseline transcript abundance of inflammatory markers in the liver. Upon lipopolysaccharide challenge to elicit an acute inflammatory response, arsenic exposure, but not zinc deficiency, resulted in an increase in proinflammatory response. In summary, zinc deficiency and arsenic exposure can function independently or cooperatively to affect zinc status, oxidant stress, and proinflammatory response. The results highlight the need to consider both nutritional status and arsenic exposures together when considering their impact on health outcomes in susceptible populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.