Evidence map›Paper›PMID 30635721›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2019

Fundus autofluorescence and ellipsoid zone (EZ) line width can be an outcome measurement in RHO-associated autosomal dominant retinitis pigmentosa.

Vitor K L Takahashi, Júlia T Takiuti, Jose R L Carvalho-Jr, Christine L Xu, Jimmy K Duong, Vinit B Mahajan, Stephen H Tsang

Abstract read
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In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

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  13. Association of retinal biomarkers and choroidal vascularity index on optical coherence tomography using binarization method in retinitis pigmentosa.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020
    Article
  14. Article
  15. Autosomal Dominant Retinitis Pigmentosa Due to Class BInternational journal of molecular sciences · 2019
    Observational
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Vitor K L TakahashiDepartment of Ophthalmology, Columbia University, New York, NY, USA.
Júlia T TakiutiDepartment of Ophthalmology, Columbia University, New York, NY, USA.
Jose R L Carvalho-JrDepartment of Ophthalmology, Columbia University, New York, NY, USA.
Christine L XuDepartment of Ophthalmology, Columbia University, New York, NY, USA.
Jimmy K DuongDepartment of Biostatistics, Columbia University, New York, NY, USA.
Vinit B MahajanOmics Laboratory, Department of Ophthalmology, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Stephen H TsangDepartment of Ophthalmology, Columbia University, New York, NY, USA. sht2@cumc.columbia.edu.ORCID http://orcid.org/0000-0001-9082-2427
Stem Cell Institute · PAColumbia University · USColumbia University Irving Medical Center · USUniversidade de São Paulo · BRVA Palo Alto Health Care System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the progression of retinitis pigmentosa (RP) due to mutations in rhodopsin (RHO) by measuring the short-wavelength autofluorescence (SW-AF) increased autofluorescence ring and ellipsoid zone (EZ)-line width.

methodsFundus autofluorescence (FAF) and spectral domain optical coherence tomography (SD-OCT) images were obtained from 10 patients with autosomal dominant RP due to mutations in the RHO gene. Measurements of ring area on FAF images, as well as the EZ line width on SD-OCT images and horizontal, vertical diameter, were performed by two independent masked graders.

resultsThe ring area decreased by a rate of 0.6 ± 0.2 mm

conclusionsWe observed SW-AF ring constriction and a progressive loss of EZ line width over time.

Indexed as

MutationAdolescentAdultAgedChildDisease ProgressionFemaleFluorescein AngiographyFundus OculiHumansMaleMiddle AgedOptical ImagingRetinaRetinitis PigmentosaRhodopsinRhodopsinAutosomal dominantDisease progressionRetinitis pigmentosaRHO

Identifiers

PMID30635721
OpenAlexW2909801889

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.