Evidence map›Paper›PMID 30635658›Full record

ArticleGenes and immunity2020

Mother-child histocompatibility and risk of rheumatoid arthritis and systemic lupus erythematosus among mothers.

Giovanna I Cruz, Xiaorong Shao, Hong Quach, Diana Quach, Kimberly A Ho, Kirsten Sterba, Janelle A Noble, Nikolaos A Patsopoulos, Michael P Busch, Darrell J Triulzi and 7 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 9 institutions in 3 countries.

Giovanna I CruzGenetic Epidemiology and Genomics Lab, Division of Epidemiology, School of Public Health, University of California Berkeley, 324 Stanley Hall, Berkeley, CA, 94720-3220, USA.
Xiaorong ShaoGenetic Epidemiology and Genomics Lab, Division of Epidemiology, School of Public Health, University of California Berkeley, 324 Stanley Hall, Berkeley, CA, 94720-3220, USA.
Hong QuachGenetic Epidemiology and Genomics Lab, Division of Epidemiology, School of Public Health, University of California Berkeley, 324 Stanley Hall, Berkeley, CA, 94720-3220, USA.
Diana QuachGenetic Epidemiology and Genomics Lab, Division of Epidemiology, School of Public Health, University of California Berkeley, 324 Stanley Hall, Berkeley, CA, 94720-3220, USA.
Kimberly A HoRosalind Russell/Ephraim P. Engleman Rheumatology Research Center, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.
Kirsten SterbaRosalind Russell/Ephraim P. Engleman Rheumatology Research Center, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.
Janelle A NobleChildren's Hospital Oakland Research Institute, 5700 M.L.K. Jr. Way, Oakland, CA, 94609, USA.
Nikolaos A PatsopoulosDivision of Genetics, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA.
Michael P BuschBlood Systems Research Institute, 270 Masonic Avenue, San Francisco, CA, 94118-4417, USA.
Darrell J TriulziInstitute for Transfusion Medicine, Department of Pathology, University of Pittsburgh, 3636 Blvd. of the Allies, Pittsburgh, PA, 15213, USA.
Nektarios LadasInstitute for Transfusion Medicine, Hannover Medical School, Hannover, Germany.
Rainer BlasczykInstitute for Transfusion Medicine, Hannover Medical School, Hannover, Germany.
Wendy S W WongDivision of Medical Genomics, Inova Translational Medicine Institute, 8110 Gatehouse Road, Falls Church, VA, 22042, USA.ORCID http://orcid.org/0000-0001-9850-3797
Benjamin D SolomonDivision of Medical Genomics, Inova Translational Medicine Institute, 8110 Gatehouse Road, Falls Church, VA, 22042, USA.
John E NiederhuberDivision of Medical Genomics, Inova Translational Medicine Institute, 8110 Gatehouse Road, Falls Church, VA, 22042, USA.
Lindsey A CriswellRosalind Russell/Ephraim P. Engleman Rheumatology Research Center, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.
Lisa F BarcellosGenetic Epidemiology and Genomics Lab, Division of Epidemiology, School of Public Health, University of California Berkeley, 324 Stanley Hall, Berkeley, CA, 94720-3220, USA. lbarcellos@berkeley.edu.
University of California, Berkeley · USUniversity of California, San Francisco · USMedizinische Hochschule Hannover · DEBlood Systems Research Institute · USBroad Institute · USChildren's Research Hospital · JPJohns Hopkins University · USQB3 · USUniversity of Pittsburgh · US

Funding

ZD1839 FOR MALIGNANT ASTROCYTOMA OR GLIOBLASTOMA AND MENINGIOMAM01RR000079 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KESSLER, DAVID A · 1985 to 2006
$26.0M
The Interplay of Sociodemographic and Genetic Factors in SLE Health DisparitiesP60AR053308 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KATZ, PATRICIA P · 2006 to 2016
$11.8M
RESOURCE-BASED CENTER FOR THE ADVANCEMENT OF PRECISION MEDICINE IN RHEUMATOLOGYP30AR070155 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mary C Nakamura · 2016 to 2026
$8.2M
Dissecting the HLA contribution to Rheumatoid ArthritisR01AI065841 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CRISWELL, LINDSEY ANN · 2006 to 2010
$3.2M
Novel strategies for defining the role of HLA in SLER01AR052300 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CRISWELL, LINDSEY ANN · 2005 to 2009
$2.8M
Immunogenetic Studies of Autoimmune DiseaseR01AI059829 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI BARCELLOS, LISA F · 2004 to 2008
$1.9M
TESTING SLE CANDIDATE LOCI USING CASES AND THEIR PARENTSR01AR044804 · NIAMS · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI CRISWELL, LINDSEY ANN · 1999 to 2003
$1.1M
Mother-child genetic contributions to autoimmunityR21AI117879 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI BARCELLOS, LISA F · 2015 to 2016
$447k
Fetal-Maternal Histocompatibility and Autoimmune DiseaseF31AI116064 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI CRUZ, GIOVANNA · 2015 to 2016
$62k
NCRR NIH HHS M01 RR000079NIAID NIH HHS F31 AI116064NIAID NIH HHS R01 AI059829NIAID NIH HHS R01 AI065841NIAID NIH HHS R21 AI117879NIAMS NIH HHS P30 AR070155NIAMS NIH HHS P60 AR053308NIAMS NIH HHS R01 AR052300U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AR052300U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R01AR044804
6 · The paper itself

Abstract

The study objective was to test the hypothesis that having histocompatible children increases the risk of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), possibly by contributing to the persistence of fetal cells acquired during pregnancy. We conducted a case control study using data from the UC San Francisco Mother Child Immunogenetic Study and studies at the Inova Translational Medicine Institute. We imputed human leukocyte antigen (HLA) alleles and minor histocompatibility antigens (mHags). We created a variable of exposure to histocompatible children. We estimated an average sequence similarity matching (SSM) score for each mother based on discordant mother-child alleles as a measure of histocompatibility. We used logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals. A total of 138 RA, 117 SLE, and 913 control mothers were analyzed. Increased risk of RA was associated with having any child compatible at HLA-B (OR 1.9; 1.2-3.1), DPB1 (OR 1.8; 1.2-2.6) or DQB1 (OR 1.8; 1.2-2.7). Compatibility at mHag ZAPHIR was associated with reduced risk of SLE among mothers carrying the HLA-restriction allele B*07:02 (n = 262; OR 0.4; 0.2-0.8). Our findings support the hypothesis that mother-child histocompatibility is associated with risk of RA and SLE.

Indexed as

AdultAllelesArthritis, RheumatoidCase-Control StudiesChildFemaleGene FrequencyGenetic Predisposition to DiseaseHistocompatibilityHistocompatibility Antigens Class IHLA-B AntigensHLA-DQ beta-ChainsHumansLupus Erythematosus, SystemicMaleMothersHistocompatibility Antigens Class IHLA-B AntigensHLA-DQbeta antigenHLA-DQ beta-Chains

Identifiers

PMID30635658
PMCPMC7039805
OpenAlexW2909205160

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.