Evidence map›Paper›PMID 30635558›Full record

ArticleNature communications2019

Improved state-level influenza nowcasting in the United States leveraging Internet-based data and network approaches.

Fred S Lu, Mohammad W Hattab, Cesar Leonardo Clemente, Matthew Biggerstaff, Mauricio Santillana

Abstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Ensemble approaches for short-term dengue fever forecasts: A global evaluation study.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fred S LuComputational Health Informatics Program, Boston Children's Hospital, Boston, MA, 02115, USA. fredlu.flac@gmail.com.ORCID http://orcid.org/0000-0003-1026-5734
Mohammad W HattabWyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA, 02115, USA.
Cesar Leonardo ClementeTecnológico de Monterrey, 64849, Monterrey, N.L., Mexico.
Matthew BiggerstaffInfluenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA, 30333, USA.
Mauricio SantillanaComputational Health Informatics Program, Boston Children's Hospital, Boston, MA, 02115, USA. msantill@g.harvard.edu.

Funding

Development of an Open-Source and Data-Driven Modeling Platform to Monitor and Forecast Disease ActivityR01GM130668 · NIGMS · NORTHEASTERN UNIVERSITY · PI SANTILLANA, MAURICIO · 2018 to 2022
$1.9M
NIGMS NIH HHS R01 GM130668
6 · The paper itself

Abstract

In the presence of health threats, precision public health approaches aim to provide targeted, timely, and population-specific interventions. Accurate surveillance methodologies that can estimate infectious disease activity ahead of official healthcare-based reports, at relevant spatial resolutions, are important for achieving this goal. Here we introduce a methodological framework which dynamically combines two distinct influenza tracking techniques, using an ensemble machine learning approach, to achieve improved state-level influenza activity estimates in the United States. The two predictive techniques behind the ensemble utilize (1) a self-correcting statistical method combining influenza-related Google search frequencies, information from electronic health records, and historical flu trends within each state, and (2) a network-based approach leveraging spatio-temporal synchronicities observed in historical influenza activity across states. The ensemble considerably outperforms each component method in addition to previously proposed state-specific methods for influenza tracking, with higher correlations and lower prediction errors.

Indexed as

Epidemiological MonitoringData AnalysisDatabases, FactualElectronic Health RecordsHumansInfluenza, HumanInternetSearch EngineUnited States

Identifiers

PMID30635558
PMCPMC6329822

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.