Evidence map›Paper›PMID 30635470›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2019

Inhibition of CD38 with the Thiazoloquin(az)olin(on)e 78c Protects the Heart against Postischemic Injury.

James Boslett, Nikhil Reddy, Yasmin A Alzarie, Jay L Zweier

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. CD38 connects the heart and brain.Translational psychiatry · 2025
    Review
  3. CD38Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  4. Review
  5. Review
  6. NADCell communication and signaling : CCS · 2024
    Review
  7. NAD metabolism and heart failure: Mechanisms and therapeutic potentials.Journal of molecular and cellular cardiology · 2024
    Review
  8. NAD in pathological cardiac remodeling: Metabolic regulation and beyond.Biochimica et biophysica acta. Molecular basis of disease · 2024
    Review
  9. Review
  10. NADSignal transduction and targeted therapy · 2023
    Article
  11. Article
  12. Review
  13. Mechanism of CD38 via NADInternational journal of medical sciences · 2023
    Review
  14. Review
  15. Harnessing NADCurrent heart failure reports · 2022
    Review
  16. Research progress in the role of CD38 in clinical tumor treatment.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022
    Article
  17. NADJournal of lipid and atherosclerosis · 2022
    Review
  18. Benefits in cardiac function by CD38 suppression: Improvement in NADJournal of molecular and cellular cardiology · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

James BoslettDepartment of Internal Medicine, Division of Cardiovascular Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, Ohio.
Nikhil ReddyDepartment of Internal Medicine, Division of Cardiovascular Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, Ohio.
Yasmin A AlzarieDepartment of Internal Medicine, Division of Cardiovascular Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, Ohio.
Jay L ZweierDepartment of Internal Medicine, Division of Cardiovascular Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, Ohio jay.zweier@osumc.edu.
The Ohio State University · US

Funding

Role of Cytoglobin in the Regulation of Vascular ToneR01HL131941 · NHLBI · OHIO STATE UNIVERSITY · PI JAY Louis ZWEIER · 2017 to 2026
$5.7M
Mechanisms of Nicotine Inhalation-Induced Cardiovascular DiseaseR01HL135648 · NHLBI · OHIO STATE UNIVERSITY · PI ZWEIER, JAY LOUIS · 2017 to 2021
$2.6M
NHLBI NIH HHS R01 HL131941NHLBI NIH HHS R01 HL135648
6 · The paper itself

Abstract

Inhibition of and genetic deletion of the NAD(P)

Indexed as

ADP-ribosyl Cyclase 1AnimalsBiological TransportBiopterinsEndotheliumGlycoside Hydrolase InhibitorsHeartMiceMice, Inbred C57BLMyocardial ContractionMyocardial Reperfusion InjuryNADPNitric Oxide SynthaseQuinazolinesADP-ribosyl Cyclase 1BiopterinsGlycoside Hydrolase InhibitorsNADPNitric Oxide SynthaseQuinazolinessapropterin

Identifiers

PMID30635470
PMCPMC6413770
OpenAlexW2910447611

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.