Evidence map›Paper›PMID 30635451›Full record

ArticleThe Veterinary record2019

Pilot study of head conformation changes over time in the Cavalier King Charles spaniel breed.

Susan Penelope Knowler, Lena Gillstedt, Thomas J Mitchell, Jelena Jovanovik, Holger Andreas Volk, Clare Rusbridge

Open access · hybridAbstract read
In one paragraph

Article in The Veterinary record, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Susan Penelope KnowlerFaculty of Health and Medical Sciences, School of Veterinary Medicine, University of Surrey, Guildford, UK.ORCID 0000-0001-8727-8440
Lena GillstedtVerus Info, Enköping, Sweden.
Thomas J MitchellCranbrook Veterinary Centre, Rockbeare, UK.
Jelena JovanovikNeurology Department, Fitzpatrick Referrals, Godalming, UK.
Holger Andreas VolkDepartment of Clinical Science and Services, Royal Veterinary College, Hatfield, UK.ORCID 0000-0002-7312-638X
Clare RusbridgeFaculty of Health and Medical Sciences, School of Veterinary Medicine, University of Surrey, Guildford, UK.ORCID 0000-0002-3366-2110
University of Surrey · GBCollege of the Rockies · CARoyal Veterinary College · GBSatellite Observing Systems (United Kingdom) · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Modern interpretation of head conformation in the Cavalier King Charles spaniel (CKCS) has favoured a smaller, more exaggerated, brachycephalic type than originally described in the 1929 breed standard. Recent research studies identified brachycephaly and reduced hind cranium as two conformational (dysmorphic) features that increase risk for symptomatic Chiari-like malformation and secondary syringomyelia (SM). A prospective pilot study investigated the hypothesis that dysmorphic head features could be assessed visually and correlated with risk of SM. Thirteen CKCS, selected from anonymised photographic evidence, were physically appraised by authorised Kennel Club judges using a head shape checklist. These subjective evaluations were then matched with objective measurements of the cranium (cephalic index and rostrocaudal doming) and their subsequent MRI. A positive correlation (P=0.039) between the judges' checklist score and rostrocaudal doming (hindskull ratio) and a positive correlation between the cephalic index and hindskull ratio (P=0.042) were identified. Five CKCS had no SM and their status tallied with 62 per cent of the judges' evaluation. Although the ability of adjudicators to identify differences in head conformation varied, there was sufficient association between the dysmorphic parameters and the risk of SM to cause concern and propose a larger study in CKCS breed.

Indexed as

AnimalsBreedingDog DiseasesDogsHeadPilot ProjectsProspective StudiesRiskSyringomyeliabrachycephaliccephalic indexChiari-like malformationoccipital bone hypoplasiasyringomyeliatoy breed dogs

Identifiers

PMID30635451
PMCPMC6589453
OpenAlexW2908549362

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.