Evidence map›Paper›PMID 30635400›Full record

ArticleThe Journal of biological chemistry2019

F-box protein-32 down-regulates small-conductance calcium-activated potassium channel 2 in diabetic mouse atria.

Tian-You Ling, Fu Yi, Tong Lu, Xiao-Li Wang, Xiaojing Sun, Monte S Willis, Li-Qun Wu, Win-Kuang Shen, John P Adelman, Hon-Chi Lee

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Small-conductance calcium-activated potassium channels in the heart: expression, regulation and pathological implications.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  7. Review
  8. Article
  9. Review
  10. Genetic mapping of developmental trajectories for complex traits and diseases.Computational and structural biotechnology journal · 2021
    Article
  11. FBXO34 Regulates the G2/M Transition and Anaphase Entry in Meiotic Oocytes.Frontiers in cell and developmental biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Tian-You LingFrom the Department of Cardiology, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200025, China.
Fu Yithe Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota 55905, xjcardio@fmmu.edu.cn.
Tong Luthe Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota 55905.
Xiao-Li Wangthe Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota 55905.
Xiaojing Sunthe Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota 55905.
Monte S Willisthe Department of Pathology and Laboratory Medicine, Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, Indiana 46202.
Li-Qun WuFrom the Department of Cardiology, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200025, China.
Win-Kuang Shenthe Department of Cardiovascular Diseases, Mayo Clinic, Phoenix, Arizona 85259, and.
John P Adelmanthe Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239.
Hon-Chi Leethe Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota 55905, lee.honchi@mayo.edu.
Mayo Clinic · USRuijin Hospital · CNIndiana University – Purdue University Indianapolis · USMayo Clinic in Florida · USVollum Institute · USXijing Hospital · CN

Funding

Type 2 Diabetes and Vascular BK Channel RegulationR01HL074180 · NHLBI · MAYO CLINIC ROCHESTER · PI LEE, HON-CHI · 2003 to 2018
$4.8M
Endothelial BK Channel Regulation by Caveolae TargetingR01HL080118 · NHLBI · MAYO CLINIC ROCHESTER · PI LEE, HON-CHI · 2006 to 2010
$1.8M
Regulation of Vascular BK Channels in DiabetesR56HL074180 · NHLBI · MAYO CLINIC ROCHESTER · PI LEE, HON-CHI · 2008 to 2008
$378k
NHLBI NIH HHS R01 HL074180NHLBI NIH HHS R01 HL080118NHLBI NIH HHS R56 HL074180
6 · The paper itself

Abstract

Diabetes mellitus (DM) is an independent risk factor for atrial fibrillation, but the underlying ionic mechanism for this association remains unclear. We recently reported that expression of the small-conductance calcium-activated potassium channel 2 (SK2, encoded by

Indexed as

Down-RegulationAnimalsDiabetes Mellitus, ExperimentalMiceMuscle ProteinsProteasome Endopeptidase ComplexSKP Cullin F-Box Protein LigasesSmall-Conductance Calcium-Activated Potassium ChannelsStreptozocinTumor Cells, CulturedUbiquitinFbxo32 protein, mouseKcnn2 protein, mouseMuscle ProteinsProteasome Endopeptidase ComplexSKP Cullin F-Box Protein LigasesSmall-Conductance Calcium-Activated Potassium ChannelsStreptozocinUbiquitinatrial fibrillationatrogin-1cardiomyocytecardiovascular diseasediabetesdiabetes mellitusHL-1 cellspotassium channelprotein degradationSK channelsubiquitin ligase

Identifiers

PMID30635400
PMCPMC6422073
OpenAlexW2910539715

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.