ArticleThe Journal of experimental medicine2019
Heterozygous
Open access · bronzeAbstract read
In one paragraph
Article in The Journal of experimental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 86 citations in OpenAlex.
- TBK1 eliminates aggregation-prone monomeric TDP-43 through an IFNβ-immunoproteasome pathway in ALS models.EMBO reports · 2026Article
- Innate immune crosstalk in ALS/FTD pathogenesis.Cell insight · 2026Review
- [Mechanisms of cGAS-STING signaling pathway mediated neuroinflammation in central nervous system and their therapeutic implications].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026Review
- The Gut Microbiome in Amyotrophic Lateral Sclerosis: Emerging Mechanisms and Therapeutic Potential.Molecular neurobiology · 2026Review
- TBK1 activity regulates the directionality of axonal transport of signalling endosomes.Life science alliance · 2026Article
- Review
- Dysregulated lactate metabolism synergizes with ALS genetic risk factors to accelerate motor decline.PloS one · 2026Article
- Minding the gates: dual cell-autonomous and non-cell-autonomous mechanisms of TBK1 in ALS/FTD.Frontiers in neuroscience · 2026Review
- Non-cell autonomous autophagy in amyotrophic lateral sclerosis: A new promising target?Neurobiology of disease · 2026Review
- Age-dependent removal of Atg9-containing vesicle accumulations in motoneuron disease models by physical exercise.Translational neurodegeneration · 2025Article
- CRISPR/Cas9 a genomic engineering technology for treatment in ALS mouse models.Regenerative therapy · 2025Review
- Dysregulated lactate metabolism synergizes with ALS genetic risk factors to accelerate motor decline.bioRxiv : the preprint server for biology · 2025Article
- Optineurin Shapes Basal and LPS-Induced Transcriptomes in BV2 Microglia.International journal of molecular sciences · 2025Article
- Exploring TANK-Binding Kinase 1 in Amyotrophic Lateral Sclerosis: From Structural Mechanisms to Machine Learning-Guided Therapeutics.Life (Basel, Switzerland) · 2025Review
- ALS/FTD-linked TBK1 deficiency in microglia induces an aged-like microglial signature and drives social recognition deficits in mice.Nature communications · 2025Article
- Protein kinases in neurodegenerative diseases: current understandings and implications for drug discovery.Signal transduction and targeted therapy · 2025Review
- TBK1 is involved in programmed cell death and ALS-related pathways in novel zebrafish models.Cell death discovery · 2025Article
- Targeting common disease pathomechanisms to treat amyotrophic lateral sclerosis.Nature reviews. Neurology · 2025Review
- The role of autophagy in the pathogenesis and treatment of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).Autophagy reports · 2025Review
- Axonopathy Underlying Amyotrophic Lateral Sclerosis: Unraveling Complex Pathways and Therapeutic Insights.Neuroscience bulletin · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 4 institutions in 3 countries.
David BrennerDepartment of Neurology, University of Ulm, Ulm, Germany.ORCID 0000-0002-1535-3146
Kirsten SieverdingDepartment of Neurology, University of Ulm, Ulm, Germany.
Clara BrunoDepartment of Neurology, University of Ulm, Ulm, Germany.
Patrick LüningschrörInstitute of Clinical Neurobiology, University Hospital of Wuerzburg, Wuerzburg, Germany.
Eva BuckDepartment of Neurology, University of Ulm, Ulm, Germany.
Simon MungwaInstitute of Clinical Neurobiology, University Hospital of Wuerzburg, Wuerzburg, Germany.
Lena FischerDepartment of Neurology, University of Ulm, Ulm, Germany.
Sarah J BrockmannDepartment of Neurology, University of Ulm, Ulm, Germany.
Johannes UlmerDepartment of Neurology, University of Ulm, Ulm, Germany.
Corinna BliederhäuserDepartment of Neurology, University of Ulm, Ulm, Germany.
Clémentine E PhilibertInstitut du Cerveau et de la Moelle Épinière, Institut National de la Santé et de la Recherche Médicale Unité 1127, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7225, Sorbonne Université, Paris, France.
Takashi SatohDepartment of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
Shizuo AkiraDepartment of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.ORCID 0000-0001-7602-9617
Séverine BoilléeInstitut du Cerveau et de la Moelle Épinière, Institut National de la Santé et de la Recherche Médicale Unité 1127, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7225, Sorbonne Université, Paris, France.
Benjamin MayerInstitute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
Michael SendtnerInstitute of Clinical Neurobiology, University Hospital of Wuerzburg, Wuerzburg, Germany.ORCID 0000-0002-4737-2974
Albert C LudolphDepartment of Neurology, University of Ulm, Ulm, Germany.
Karin M DanzerDepartment of Neurology, University of Ulm, Ulm, Germany.
Christian S LobsigerInstitut du Cerveau et de la Moelle Épinière, Institut National de la Santé et de la Recherche Médicale Unité 1127, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7225, Sorbonne Université, Paris, France.
Axel FreischmidtDepartment of Neurology, University of Ulm, Ulm, Germany.
Jochen H WeishauptDepartment of Neurology, University of Ulm, Ulm, Germany jochen.weishaupt@uni-ulm.de.ORCID 0000-0002-3399-9784
Universität Ulm · DEInserm · FRUniversitätsklinikum Würzburg · DEThe University of Osaka · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heterozygous loss-of-function mutations of
Indexed as
Amyotrophic Lateral SclerosisBrainGene DeletionMotor NeuronsProtein Serine-Threonine KinasesAnimalsAutophagic Cell DeathDisease Models, AnimalLoss of Function MutationMiceMice, KnockoutMicrogliaSuperoxide DismutaseSuperoxide Dismutase-1Protein Serine-Threonine KinasesSOD1 G93A proteinSod1 protein, mouseSuperoxide DismutaseSuperoxide Dismutase-1Tbk1 protein, mouse
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.