Evidence map›Paper›PMID 30635334›Full record

ArticleThe EMBO journal2019

Atoh1

David Castillo-Azofeifa, Elena N Fazio, Roy Nattiv, Hayley J Good, Tomas Wald, Michael A Pest, Frederic J de Sauvage, Ophir D Klein, Samuel Asfaha

Open access · bronzeAbstract read
In one paragraph

Article in The EMBO journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 75 citations in OpenAlex.

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  7. c-KitCell death and differentiation · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

David Castillo-AzofeifaDepartment of Orofacial Sciences and Program in Craniofacial Biology, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-9121-4829
Elena N FazioDepartment of Medicine, University of Western Ontario, London, ON, Canada.
Roy NattivDepartment of Orofacial Sciences and Program in Craniofacial Biology, University of California, San Francisco, San Francisco, CA, USA.
Hayley J GoodDepartment of Medicine, University of Western Ontario, London, ON, Canada.
Tomas WaldDepartment of Orofacial Sciences and Program in Craniofacial Biology, University of California, San Francisco, San Francisco, CA, USA.
Michael A PestDepartment of Physiology & Pharmacology, University of Western Ontario, London, ON, Canada.
Frederic J de SauvageDepartment of Molecular Oncology, Genentech, South San Francisco, CA, USA.
Ophir D KleinDepartment of Orofacial Sciences and Program in Craniofacial Biology, University of California, San Francisco, San Francisco, CA, USA ophir.klein@ucsf.edu sasfaha2@uwo.ca.ORCID 0000-0002-6254-7082
Samuel AsfahaDepartment of Medicine, University of Western Ontario, London, ON, Canada ophir.klein@ucsf.edu sasfaha2@uwo.ca.ORCID 0000-0001-6972-0338
University of California, San Francisco · USWestern University · CAMolecular Oncology (United States) · US

Funding

Harnessing natural stem cell-based strategies for mammalian dental renewalR35DE026602 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KLEIN, OPHIR D · 2016 to 2023
$8.0M
TRAINING PROGRAM IN PEDIATRIC GASTROENTEROLOGY/NUTRITIONT32DK007762 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI James Bayrer · 1998 to 2026
$7.3M
Intestinal Stem Cell Consortium Coordinating CenterU01DK085532 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NILAND, JOYCE CAROL · 2009 to 2018
$6.5M
The roles of regional specialization, mechanical forces and epigenetic memory after perturbation and injury of the intestinal stem cell microenvironmentU01DK103147 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KLEIN, OPHIR D · 2014 to 2023
$5.4M
Limited Competition for the Continuation of the Intestinal Stem Cell Consortium Coordinating CenterU24DK085532 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NILAND, JOYCE CAROL · 2019 to 2023
$2.3M
NIDCR NIH HHS R35 DE026602NIDDK NIH HHS T32 DK007762NIDDK NIH HHS U01 DK085532NIDDK NIH HHS U01 DK103147NIDDK NIH HHS U24 DK085532
6 · The paper itself

Abstract

During homeostasis, the colonic epithelium is replenished every 3-5 days by rapidly cycling

Indexed as

RegenerationAnimalsBasic Helix-Loop-Helix ProteinsCells, CulturedColitisColonHomeostasisIntestine, SmallKeratin-19MiceReceptor, Notch1Receptors, G-Protein-CoupledStem CellsAtoh1 protein, mouseBasic Helix-Loop-Helix ProteinsKeratin-19Lgr5 protein, mouseNotch1 protein, mouseReceptor, Notch1Receptors, G-Protein-CoupledAtoh1colitisKrt19Notch1stem cells

Identifiers

PMID30635334
PMCPMC6376326
OpenAlexW2909012400

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.