Evidence map›Paper›PMID 30635297›Full record

Observational studyThe European respiratory journal2019

Telomere length and genetic variant associations with interstitial lung disease progression and survival.

Chad A Newton, Justin M Oldham, Brett Ley, Vikram Anand, Ayodeji Adegunsoye, Gabrielle Liu, Kiran Batra, Jose Torrealba, Julia Kozlitina, Craig Glazer and 4 more

Abstract readObservational Study
In one paragraph

Observational study in The European respiratory journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Guideline
  4. Pooled it
  5. Pooled it
  6. Guideline
  7. Article
  8. Article
  9. Prevalence and Prognostic Impact of Progressive Pulmonary Fibrosis.Tuberculosis and respiratory diseases · 2026
    Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Survival in familial idiopathic pulmonary fibrosis and fibrotic hypersensitivity pneumonitis.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2025
    Article
  17. Review
  18. Article
  19. Article
  20. Initiation of antifibrotic treatment in fibrosing interstitial lung disease: is the clock ticking till proven progression?European respiratory review : an official journal of the European Respiratory Society · 2025
    Review

36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Chad A NewtonDept of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Justin M OldhamDept of Internal Medicine, University of California at Davis, Davis, CA, USA.
Brett LeyDept of Medicine, University of California San Francisco, San Francisco, CA, USA.
Vikram AnandDept of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ayodeji AdegunsoyeDept of Medicine, University of Chicago, Chicago, IL, USA.
Gabrielle LiuDept of Medicine, University of California San Francisco, San Francisco, CA, USA.
Kiran BatraDept of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jose TorrealbaDept of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Julia KozlitinaEugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Craig GlazerDept of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Mary E StrekDept of Medicine, University of Chicago, Chicago, IL, USA.
Paul J WoltersDept of Medicine, University of California San Francisco, San Francisco, CA, USA.
Imre NothDept of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA.
Christine Kim GarciaDept of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Funding

UT Southwestern Center for Translational Medicine (UL1/KL2/TL1)UL1TR001105 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2013 to 2017
$24.5M
Institutional Career Development Core SupplementKL2TR001870 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M., SARKAR, URMIMALA · 2016 to 2025
$19.7M
Pulmonary Fibrosis and Telomerase DysfunctionR01HL093096 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI GARCIA, CHRISTINE KIM · 2009 to 2024
$6.9M
UT Southwestern Center for Translational Medicine (UL1/KL2/TL1KL2TR001103 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2013 to 2017
$4.0M
Architectural structure and regulation of TOLLIP in IPFR01HL130796 · NHLBI · UNIVERSITY OF VIRGINIA · PI NOTH, IMRE · 2016 to 2019
$3.1M
Elucidating the Genomic Determinants of Outcomes in Idiopathic Pulmonary FibrosisK23HL138190 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OLDHAM, JUSTIN M · 2017 to 2021
$914k
NCATS NIH HHS KL2 TR001103NCATS NIH HHS KL2 TR001870NCATS NIH HHS UL1 TR001105NHLBI NIH HHS K23 HL138190NHLBI NIH HHS R01 HL093096NHLBI NIH HHS R01 HL130796
6 · The paper itself

Abstract

Leukocyte telomere length (LTL),

Indexed as

AgedCohort StudiesDisease ProgressionFemaleGenetic VariationHumansIntracellular Signaling Peptides and ProteinsLeukocytesLung Diseases, InterstitialMaleMiddle AgedMucin-5BRetrospective StudiesSurvival RateTelomereIntracellular Signaling Peptides and ProteinsMUC5B protein, humanMucin-5BTOLLIP protein, human

Identifiers

PMID30635297
PMCPMC6612265

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.