ArticleThe European respiratory journal2019
Which definition of a central tumour is more predictive of occult mediastinal metastasis in nonsmall cell lung cancer patients with radiological N0 disease?
Article in The European respiratory journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 55 citations in OpenAlex.
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- Extent of Endobronchial Ultrasound Nodal Sampling and Risk of Pathologic N2 Upstaging in Clinical N0-N1 Non-Small Cell Lung Cancer.Thoracic cancer · 2026Article
- Learning curve, safety and diagnostic yield of the GalaxyJournal of thoracic disease · 2026Article
- Ten-year review of endobronchial ultrasound-guided transbronchial needle aspiration for lymph node staging in lung cancer: Comparison with guidelines.JTCVS open · 2026Article
- Adenosquamous carcinoma of the lung: Comparative CT and pathological features versus adenocarcinoma and squamous cell carcinoma.PloS one · 2026Article
- Approaches to Mediastinal Staging in NSCLC Among Thoracic Surgeons: A Survey Study From Türkiye.Sisli Etfal Hastanesi tip bulteni · 2026Article
- Balancing oncological control and immune preservation in the immunotherapy era: revisiting lymph node dissection in non-small cell lung cancer.Frontiers in oncology · 2025Review
- Clinical Effect of Endosonography on Overall Survival in Patients with Radiological N1 Non-Small Cell Lung Cancer.Cancer research and treatment · 2024Article
- [Impact of the Size and Depth of Pulmonary Nodules on the Surgical Approach for Lung Resection in the Treatment of Early-stage Lung Cancer ≤2 cm].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2024Article
- Role of invasive mediastinal nodal staging in survival outcomes of patients with non-small cell lung cancer and without radiologic lymph node metastasis: a retrospective cohort study.EClinicalMedicine · 2024Article
- Machine learning model for circulating tumor DNA detection in chronic obstructive pulmonary disease patients with lung cancer.Translational lung cancer research · 2024Article
- Clinical and Bronchoscopy Assessment in Diagnosing the Histopathology Type of Primary Central Lung Tumors.The open respiratory medicine journal · 2024Article
- PET/CT based cross-modal deep learning signature to predict occult nodal metastasis in lung cancer.Nature communications · 2023Article
- Diagnostic Performance of Endosonography to Detect Mediastinal Lymph Node Metastasis in Patients with Radiological N1 Non-Small Cell Lung Cancer.Cancer research and treatment · 2023Article
- Endoscopic Technologies for Peripheral Pulmonary Lesions: From Diagnosis to Therapy.Life (Basel, Switzerland) · 2023Review
- Solitary Pulmonary Capillary Hemangioma: CT and PET-CT Features with Clinicopathologic Correlation.Diagnostics (Basel, Switzerland) · 2022Article
- Article
- Partitioning the lung field based on the depth ratio in three-dimensional space.Translational lung cancer research · 2022Article
- Risk analysis in peripheral clinical T1 non-small cell lung cancer correlations between tumor-to-blood standardized uptake ratio onQuantitative imaging in medicine and surgery · 2022Article
- Differences in detection patterns, characteristics, and outcomes of central and peripheral lung cancers in low-dose computed tomography screening.Translational lung cancer research · 2021Article
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Authors and funding
9 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGuidelines recommend invasive mediastinal staging for centrally located tumours, even in radiological N0 nonsmall cell lung cancer (NSCLC). However, there is no uniform definition of a central tumour that is more predictive of occult mediastinal metastasis.
methodsA total of 1337 consecutive patients with radiological N0 disease underwent invasive mediastinal staging. Tumours were categorised into central and peripheral by seven different definitions.
resultsAbout 7% (93 out of 1337) of patients had occult N2 disease, and they had significantly larger tumour size and more solid tumours on computed tomography. After adjustment for patient- and tumour-related characteristics, only the central tumour definition of the inner one-third of the hemithorax adopted by drawing concentric lines arising from the midline significantly predicted occult N2 disease (adjusted OR 2.13, 95% CI 1.17-3.87; p=0.013). This association was maintained after excluding patients with pure ground-glass nodules (adjusted OR 2.54, 95% CI 1.37-4.71; p=0.003) or only including those with solid tumours (adjusted OR 2.30, 95% CI 1.08-4.88; p=0.030).
conclusionsWe suggest that a central tumour should be defined using the inner one-third of the hemithorax adopted by drawing concentric lines from the midline. This is particularly useful for predicting occult N2 disease in patients with NSCLC.
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