Evidence map›Paper›PMID 30635238›Full record

ArticleImmunity2019

Impaired Tumor-Necrosis-Factor-α-driven Dendritic Cell Activation Limits Lipopolysaccharide-Induced Protection from Allergic Inflammation in Infants.

Holly Bachus, Kamaljeet Kaur, Amber M Papillion, Tatiana T Marquez-Lago, Zhihong Yu, André Ballesteros-Tato, Sadis Matalon, Beatriz León

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 64 citations in OpenAlex.

  1. Review
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  11. CGRP restrains CD4Frontiers in immunology · 2025
    Article
  12. Review
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  14. Distinctive CD39Nature communications · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Holly BachusDepartment of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Kamaljeet KaurDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Amber M PapillionDepartment of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Tatiana T Marquez-LagoDepartment of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA.
Zhihong YuDepartment of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL, USA.
André Ballesteros-TatoDepartment of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Sadis MatalonDepartment of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Beatriz LeónDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: bleon@uab.edu.
University of Alabama at Birmingham · US

Funding

Regulation of T cell responses to allergens and environmental microbesR01AI116584 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LUND, FRANCES E. · 2015 to 2024
$4.1M
Bromine Inhalation Induced Lung Injury: Novel Mechanisms and Treatment StrategiesU01ES026458 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MATALON, SADIS · 2015 to 2019
$3.9M
Training Program in Rheumatic and Musculoskeletal Diseases ResearchT32AR069516 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI John D Mountz · 2016 to 2026
$2.6M
Regulation of T-cell dependent B cell responses to influenzaR01AI110480 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BALLESTEROS-TATO, ANDRE · 2015 to 2019
$1.8M
NIAID NIH HHS R01 AI110480NIAID NIH HHS R01 AI116584NIAMS NIH HHS T32 AR069516NIEHS NIH HHS U01 ES026458
6 · The paper itself

Abstract

Infants have a higher risk of developing allergic asthma than adults. However, the underlying mechanism remains unknown. We show here that sensitization of mice with house-dust mites (HDMs) in the presence of low-dose lipopolysaccharide (LPS) prevented T helper 2 (Th2) cell allergic responses in adult, but not infant, mice. Mechanistically, adult CD11b

Indexed as

AdultAnimalsAnimals, NewbornAntigens, DermatophagoidesCell DifferentiationDendritic CellsHumansHypersensitivityImmunizationInfantInflammationLipopolysaccharidesMiceMice, Inbred C57BLMice, KnockoutPyroglyphidaeAntigens, DermatophagoidesLipopolysaccharidesT-bet Transcription FactorT-Box Domain ProteinsTumor Necrosis Factor-alphaCD11b(+) lung dendritic cellshouse-dust miteneonatal and infant allergic responsesT-bet(+) dendritic cellsTh2-driven inflammationTNF-α-driven activation

Identifiers

PMID30635238
PMCPMC6335154
OpenAlexW2910233510

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.