Evidence map›Paper›PMID 30635024›Full record

ArticleArthritis research & therapy2019

Weight loss improves disease activity in patients with psoriatic arthritis and obesity: an interventional study.

Eva Klingberg, Annelie Bilberg, Sofia Björkman, Martin Hedberg, Lennart Jacobsson, Helena Forsblad-d'Elia, Hans Carlsten, Björn Eliasson, Ingrid Larsson

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis research & therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02917434 (Effects of Weight-loss Treatment in Obese Patients With Psoriatic Arthritis), which is not on this map. Cited by 79 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 2 pooled it
14.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02917434 nacompletednot on this map

Effects of Weight-loss Treatment in Obese Patients With Psoriatic Arthritis

TypeinterventionalSponsorVastra Gotaland RegionRan2016 to 2021Enrolled90ConditionsObesity, Psoriatic Arthritis, Metabolic Syndrome, PsoriasisArmsVery Low Energy Diet (VLED)
3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 2 syntheses or guidelines pooled it, 165 citations in OpenAlex.

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  9. Lifestyle Modification for the Management of Psoriatic Arthritis.American journal of lifestyle medicine · 2026
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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Eva KlingbergDepartment of Rheumatology and Inflammation Research, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden. eva.klingberg@vgregion.se.ORCID 0000-0001-6858-6413
Annelie BilbergInstitute of Neuroscience and Physiology, Section of Health and Rehabilitation, Physiotherapy, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Sofia BjörkmanDepartment of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Martin HedbergDepartment of Rheumatology, Hospital of Borås, Borås, Sweden.
Lennart JacobssonDepartment of Rheumatology and Inflammation Research, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Helena Forsblad-d'EliaDepartment of Rheumatology and Inflammation Research, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Hans CarlstenDepartment of Rheumatology and Inflammation Research, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Björn EliassonDepartment of Medicine, Institute of Medicine, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden.
Ingrid LarssonDepartment of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
University of Gothenburg · SESahlgrenska University Hospital · SEUmeå University · SEUniversity of Borås · SE

Funding

Gothenburg Society of Medicine GLS-788661Inger Bendix foundation for medical research .Rune och Ulla Amlövs Stiftelse för Neurologisk och Reumatologisk Forskning 2016-097Stiftelsen Psoriasisfonden .The Health and Medical Care Executive Board of the Västra Götaland VGFOUREG-565931The Swedish Rheumatology Association research grant in collaboration with Roche .The Swedish state under the agreement between the Swedish Government and the county councils, the ALF-agreement ALFGBG-825511
6 · The paper itself

Abstract

backgroundObesity is over-represented in patients with psoriatic arthritis (PsA) and associated with higher disease activity, poorer effect of treatment and increased cardiovascular morbidity. Studies on the effects of weight loss are however needed. This study aimed to prospectively study the effects of weight loss treatment with very low energy diet (VLED) on disease activity in patients with PsA (CASPAR criteria) and obesity (body mass index BMI ≥ 33 kg/m

methodsVLED (640 kcal/day) was taken during 12-16 weeks, depending on pre-treatment BMI. Afterwards, an energy-restricted diet was gradually reintroduced. Weight loss treatment was given within a structured framework for support and medical follow-up. Treatment with conventional synthetic and/or biologic disease-modifying anti-rheumatic drugs was held constant from 3 months before, until 6 months after baseline. Patients were assessed with BMI, 66/68 joints count, Leeds enthesitis index, psoriasis body surface area (BSA), questionnaires and CRP at baseline, 3 and 6 months. Primary outcome was the percentage of patients reaching minimal disease activity (MDA) and secondary outcomes were reaching Psoriatic Arthritis Response Criteria (PsARC) and American College of Rheumatology (ACR) response criteria.

resultsTotally 41/46 patients completed the study, 63% women, median age 54 years (IQR 48-62). At baseline increased BMI was associated with higher disease activity and poorer function. The median weight loss was 18.7 kg (IQR 14.6-26.5) or 18.6% (IQR 14.7-26.3) of the baseline weight. A majority of the disease activity parameters improved significantly after weight loss, including 68/66 tender/swollen joints count, CRP, BSA, Leeds enthesitis index, HAQ and patient VAS for global health, pain and fatigue. A larger weight loss resulted in more improvement in a dose-response manner. The percentage of patients with MDA increased from 29 to 54%, (p = 0.002). PsARC was reached by 46.3%. The ACR 20, 50 and 70 responses were 51.2%, 34.1% and 7.3% respectively.

conclusionsShort-term weight loss treatment with VLED was associated with significant positive effects on disease activity in joints, entheses and skin in patients with PsA and obesity. The study supports the hypothesis of obesity as a promotor of disease activity in PsA.

trial registrationClinicalTrials.gov identifier: NCT02917434 , registered on September 21, 2016-retrospectively registered.

Indexed as

AdultAgedArthritis, PsoriaticDiet, ReducingDisease ProgressionFemaleFollow-Up StudiesHumansMaleMiddle AgedObesityProspective StudiesTreatment OutcomeWeight LossCardiovascular diseaseMetabolic syndromeObesityPsoriasisPsoriatic arthritisVLEDWeight loss

Identifiers

PMID30635024
PMCPMC6330463
OpenAlexW2919703717

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.