ArticleParasites & vectors2019
A cross-sectional screening by next-generation sequencing reveals Rickettsia, Coxiella, Francisella, Borrelia, Babesia, Theileria and Hemolivia species in ticks from Anatolia.
Article in Parasites & vectors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- High throughput sequencing in the diagnosis and surveillance of tick-borne diseases: A narrative review.One health (Amsterdam, Netherlands) · 2026Review
- Temporal changes in the bacterial microbiome of the salivary gland and midgut tissues of Rhipicephalus sanguineus (s.l.) ticks in South Africa.Scientific reports · 2025Article
- Molecular detection of Rickettsia aeschlimannii, Borrelia theileri, and Francisella-like endosymbionts in Camelus dromedarius and dogs in Luxor, Egypt.Scientific reports · 2025Article
- Microbiological and molecular analysis of the microbiota of insects present in the surgical area.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- DNA Barcoding Using 18S rRNA Gene Fragments for Identification of Tick-Borne Protists in Ticks in the Republic of Korea.Pathogens (Basel, Switzerland) · 2024Article
- Perception of Ticks and Tick-Borne Diseases Worldwide.Pathogens (Basel, Switzerland) · 2023Review
- An Update of Evidence for Pathogen Transmission by Ticks of the Genus Hyalomma.Pathogens (Basel, Switzerland) · 2023Article
- Molecular investigation of Coxiella burnetii and Francisella tularensis infection in ticks in northern, western, and northwestern Iran.PloS one · 2023Article
- Distribution of Tick-Borne Pathogens in Domestic Animals and Their Ticks in the Countries of the Mediterranean Basin between 2000 and 2021: A Systematic Review.Microorganisms · 2022Article
- An Update on the Laboratory Diagnosis ofPathogens (Basel, Switzerland) · 2021Review
- The specificity of Babesia-tick vector interactions: recent advances and pitfalls in molecular and field studies.Parasites & vectors · 2021Review
- Characterization of a novel transitional groupInternational journal of systematic and evolutionary microbiology · 2021Article
- Global Distribution ofPathogens (Basel, Switzerland) · 2021Review
- Rodent Ectoparasites in the Middle East: A Systematic Review and Meta-Analysis.Pathogens (Basel, Switzerland) · 2021Review
- Molecular detection of Rickettsia in fleas from micromammals in Chile.Parasites & vectors · 2020Article
- A Targeted "Next-Generation" Sequencing-Informatic Approach to Define Genetic Diversity inPathogens (Basel, Switzerland) · 2020Article
- Molecular investigation of Rickettsia spp. and Francisella tularensis in ticks from three provinces of Turkey.Experimental & applied acarology · 2020Article
- First molecular detection of Francisella-like endosymbionts in Hyalomma and Rhipicephalus tick species collected from vertebrate hosts from Sardinia island, Italy.Experimental & applied acarology · 2019Article
- Surface sterilization methods impact measures of internal microbial diversity in ticks.Parasites & vectors · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundTicks participate as arthropod vectors in the transmission of pathogenic microorganisms to humans. Several tick-borne infections have reemerged, along with newly described agents of unexplored pathogenicity. In an attempt to expand current information on tick-associated bacteria and protozoans, we performed a cross-sectional screening of ticks, using next-generation sequencing. Ticks seeking hosts and infesting domestic animals were collected in four provinces across the Aegean, Mediterranean and Central Anatolia regions of Turkey and analyzed by commonly used procedures and platforms.
resultsTwo hundred and eighty ticks comprising 10 species were evaluated in 40 pools. Contigs from tick-associated microorganisms were detected in 22 (55%) questing and 4 feeding (10%) tick pools, with multiple microorganisms identified in 12 pools. Rickettsia 16S ribosomal RNA gene, gltA, sca1 and ompA sequences were present in 7 pools (17.5%), comprising feeding Haemaphysalis parva and questing/hunting Rhipicephalus bursa, Rhipicephalus sanguineus (sensu lato) and Hyalomma marginatum specimens. A near-complete genome and conjugative plasmid of a Rickettsia hoogstraalii strain could be characterized in questing Ha. parva. Coxiella-like endosymbionts were identified in pools of questing (12/40) as well as feeding (4/40) ticks of the genera Rhipicephalus, Haemaphysalis and Hyalomma. Francisella-like endosymbionts were also detected in 22.5% (9/40) of the pools that comprise hunting Hyalomma ticks in 8 pools. Coxiella-like and Francisella-like endosymbionts formed phylogenetically distinct clusters associated with their tick hosts. Borrelia turcica was characterized in 5% (2/40) of the pools, comprising hunting Hyalomma aegyptium ticks. Co-infection of Coxiella-like endosymbiont and Babesia was noted in a questing R. sanguineus (s.l.) specimen. Furthermore, protozoan 18S rRNA gene sequences were detected in 4 pools of questing/hunting ticks (10%) and identified as Babesia ovis, Hemolivia mauritanica, Babesia and Theileria spp.
conclusionsOur metagenomic approach enabled identification of diverse pathogenic and non-pathogenic microorganisms in questing and feeding ticks in Anatolia.
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