ArticleRadiation oncology (London, England)2019
Direct radiation-induced effects on dental hard tissue.
Article in Radiation oncology (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
47 citing papers in PubMed, 104 citations in OpenAlex.
- Push-out bond strength of fiber posts to irradiated and non-irradiated intraradicular dentin.Clinical oral investigations · 2022Trial
- Effect of photon radiotherapy on microleakage and microhardness of nanohybrid resin composite restoration: an in vitro study.BMC oral health · 2026Article
- The effectiveness of lasers in treatment of dentinal hypersensitivity, a scoping review on lasers parametes and clinical protocols.Lasers in medical science · 2026Article
- Article
- Microstructural changes in irradiated teeth revealed by swept-source optical coherence tomography.Scientific reports · 2026Article
- Oral microbiota associated with radiation-related caries among nasopharyngeal carcinoma patients following radiation therapy: analysis based on a longitudinal study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Dose-Dependent Effects of Simulated Clinical Radiotherapy on the Structure and Properties of Root Dentine.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2026Article
- Radiation-induced oral side effects in head and neck cancer: a scoping review and interdisciplinary recommendations.BMC oral health · 2026Article
- Investigations of Effects of Radiotherapy, Sonic Activation and Root Canal Treatment on Fracture Resistance of Mandibular Anterior Teeth: An In Vitro Study.Journal of clinical medicine · 2026Article
- Direct radiation damage to human tooth under IMRT for head and neck cancer: physicochemical evidence supporting a non-salivary mechanism for radiation-related caries.Radiation and environmental biophysics · 2026Article
- Influence of Therapeutic Radiation and Treatment Timing on Dislodgment Resistance of Four Root Canal Sealers: An In Vitro Push-Out Bond Strength Study.International journal of dentistry · 2026Article
- The reinforcing effect of anti-caries treatments on acidic challenge resistance of irradiated enamel.PloS one · 2026Article
- Supragingival Plaque Microbial Signatures Between Radiation Related Caries and Common Caries.International dental journal · 2025Article
- Effect of gamma radiation on human enamel chemical and physical properties.BMC oral health · 2025Article
- Evaluating microbial regulation as a preventive strategy for radiation-related caries: A review.Head & face medicine · 2025Review
- Microshear bond strength of conventional and bioactive restorative materials to irradiated and non-irradiated dentin: an in vitro study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Role of diode laser (810 nm) and/or fluoride varnish for the treatment of gamma-irradiated hypersensitive human dentin (An in vitro study).Scientific reports · 2025Article
- Article
- Effect of different protocols in preventing demineralization in irradiated human enamel, in vitro study.BMC oral health · 2025Article
- Impact of radiotherapy in chemical composition and mechanical properties of human cervical dentin: an in vitro study.Journal of applied oral science : revista FOB · 2025Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundRadiation caries is a complication of radiotherapy characterized by enamel erosion and dentin exposure. The mechanisms of characteristic radiation caries formation are not well-understood. The aim of this study was to evaluate the direct radiation-induced effects on dental hard tissue and investigate their role in the formation of radiation caries.
methodsSixty non-carious third molars were divided into three groups (n = 20), which would be exposed to 0 Gy, 30 Gy, and 60 Gy radiation, respectively. After radiation, microhardness and elastic modulus were measured at four depths by means of a Vickers microhardness tester and atomic force microscopy (AFM). The microstructure was observed by scanning electron microscopy (SEM). X-ray diffraction and Raman microspectroscopy were used to determine crystal properties and protein/mineral (2931/960 cm
resultsA statistically significant decrease in microhardness and elastic modulus values 50 μm from the dentino-enamel junction (DEJ) in enamel was revealed in the 30-Gy and 60-Gy groups. With the increasing dose, destruction of interprismatic substance and fissures at the DEJ-adjacent region were found. A greater reduction of crystallinity was revealed in enamel compared with dentin. Raman spectroscopic analysis showed a slight increase of the protein/mineral ratio for enamel following accumulated radiation, while the protein/mineral ratio for dentin was decreased.
conclusionsRadiation could directly alter the mechanical properties, micro-morphology, crystal properties, and chemical composition of dental hard tissue. The early destruction of DEJ-adjacent enamel, combined with decreased crystallinity of enamel under radiation exposure, may be related to the formation of characteristic radiation caries.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.